72301-79-2|Enviroxime|(E)-2-Amino-6-benzoyl-1-(isopropylsulfonyl)benzimidazole oxime|-范德生物科技公司

Enviroxime

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names：
(E)-2-Amino-6-benzoyl-1-(isopropylsulfonyl)benzimidazole oxime
CAS号：
72301-79-2
MDL Number：
MF(分子式)： C17H18N4O3S MW(分子量)： 358.416
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Enviroxime
英文别名	LY-122772; LY122772; LY 122772; LY122771-72; NSC 346230; Enviroxime; Viroxime component B; Enviroxima.
CAS号	72301-79-2
SMILES	O=S(N1C2=CC(/C(C3=CC=CC=C3)=N/O)=CC=C2N=C1N)(C(C)C)=O
Inchi	InChI=1S/C17H18N4O3S/c1-11(2)25(23,24)21-15-10-13(8-9-14(15)19-17(21)18)16(20-22)12-6-4-3-5-7-12/h3-11,22H,1-2H3,(H2,18,19)/b20-16+
InchiKey	IWKXBHQELWQLHF-CAPFRKAQSA-N
分子式 Formula	C17H18N4O3S
分子量 Molecular Weight	358.416
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Enviroxime(CAS:72301-79-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Enviroxime, also known as LY 122772 and NSC 346230, is an anti-Infective and antiviral agent. Enviroxime targets the 3A coding region of rhinovirus and poliovirus. Combining enviroxime with disoxaril resulted in synergistic interaction.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Arita M, Kojima H, Nagano T, Okabe T, Wakita T, Shimizu H. Oxysterol-binding protein family I is the target of minor enviroxime-like compounds. J Virol. 2013 Apr;87(8):4252-60. doi: 10.1128/JVI.03546-12. Epub 2013 Jan 30. PubMed PMID: 23365445; PubMed Central PMCID: PMC3624399.

[2]Arita M, Kojima H, Nagano T, Okabe T, Wakita T, Shimizu H. Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity. J Virol. 2011 Mar;85(5):2364-72. doi: 10.1128/JVI.02249-10. Epub 2010 Dec 22. PubMed PMID: 21177810; PubMed Central PMCID: PMC3067798.

[3] Arita M, Wakita T, Shimizu H. Cellular kinase inhibitors that suppress enterovirus replication have a conserved target in viral protein 3A similar to that of enviroxime. J Gen Virol. 2009 Aug;90(Pt 8):1869-79. doi: 10.1099/vir.0.012096-0. Epub 2009 May 13. PubMed PMID: 19439558.

[4] Nikolaeva L, Galabov AS. Antiviral effect of the combination of enviroxime and disoxaril on coxsackievirus B1 infection. Acta Virol. 2000 Apr;44(2):73-8. PubMed PMID: 10989697.

[5] Nikolaeva L, Galabov AS. Cytotoxicity of the synergistic antienteroviral combination of enviroxime and disoxaril. Acta Virol. 1999 Aug;43(4):263-5. PubMed PMID: 10749374.

6: Brown-Augsburger P, Vance LM, Malcolm SK, Hsiung H, Smith DP, Heinz BA. Evidence that enviroxime targets multiple components of the rhinovirus 14 replication complex. Arch Virol. 1999;144(8):1569-85. PubMed PMID: 10486111.7: Victor F, Loncharich R, Tang J, Spitzer WA. Synthesis and antiviral activity of C2 analogs of enviroxime: an exploration of the role of critical functionality. J Med Chem. 1997 Oct 10;40(21):3478-83. PubMed PMID: 9341923.8: Victor F, Brown TJ, Campanale K, Heinz BA, Shipley LA, Su KS, Tang J, Vance LM, Spitzer WA. Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime. J Med Chem. 1997 May 9;40(10):1511-8. PubMed PMID: 9154972.9: Heinz BA, Vance LM. Sequence determinants of 3A-mediated resistance to enviroxime in rhinoviruses and enteroviruses. J Virol. 1996 Jul;70(7):4854-7. PubMed PMID: 8676522; PubMed Central PMCID: PMC190432.10: Nikolaeva L, Galabov AS. Synergistic inhibitory effect of enviroxime and disoxaril on poliovirus type 1 replication. Acta Virol. 1995 Dec;39(5-6):235-41. PubMed PMID: 8722291.1

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