220120-14-9|E-5842 (Citrate)|1-(4-(1H-1,2,4-triazol-1-yl)butyl)-4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine 2-hydroxypropane-1,2,3-tricarboxylate|-范德生物科技公司

E-5842 (Citrate)

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names：
1-(4-(1H-1,2,4-triazol-1-yl)butyl)-4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine 2-hydroxypropane-1,2,3-tricarboxylate
CAS号：
220120-14-9
MDL Number：
MF(分子式)： C23H29FN4O7 MW(分子量)： 492.5
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	E-5842 (Citrate)
英文别名	E-5842; E 5842; E5842
CAS号	220120-14-9
Inchi	InChI=1S/C17H21FN4.C6H8O7/c18-17-5-3-15(4-6-17)16-7-11-21(12-8-16)9-1-2-10-22-14-19-13-20-22;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-7,13-14H,1-2,8-12H2;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InchiKey	LTBKOSQVBVYJKW-UHFFFAOYSA-N
分子式 Formula	C23H29FN4O7
分子量 Molecular Weight	492.5
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	E-5842 (Citrate)(CAS:220120-14-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	E-5842 (Citrate) is an opioid receptor agonist potentially for the treatment of psychotic disorders
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Guzmán A, Marín AP, García C, Fernández de Henestrosa AR, Ruiz MT, TortajadaA, Marcos R. Induction of hypothermic conditions associated with increasedmicronuclei formation in sigma-1 receptor knockout mice after administration ofthe antipsychotic compound E-5842. Environ Mol Mutagen. 2008 Dec;49(9):727-33.doi: 10.1002/em.20428. PubMed PMID: 18800345.

[2]Guzmán A, García C, Fernández de Henestrosa AR, Riley S, Ruiz MT, Marín AP,Tortajada A. Assessment of the genotoxic potential of the antipsychotic sigmareceptor ligand E-5842. Mutat Res. 2006 Jun 16;605(1-2):63-77. PubMed PMID:16677850.

[3] Guzmán A, García C, Marín AP, Ruiz MT, Tortajada A, Fernández de HenestrosaAR. Induction of micronuclei in mouse bone-marrow erythrocytes in associationwith hypothermia after administration of the sigma receptor ligand E-5842. MutatRes. 2004 Dec 31;565(1):11-22. PubMed PMID: 15576235.

[4] Romero G, Pérez MP, Carceller A, Monroy X, Farré AJ, Guitart X. Changes inphosphoinositide signalling activity and levels of the alpha subunit of G(q/11)protein in rat brain induced by E-5842, a sigma(1) receptor ligand and potentialatypical antipsychotic. Neurosci Lett. 2000 Sep 1;290(3):189-92. PubMed PMID:10963895.

[5] Ovalle S, Andreu F, Pérez MP, Zamanillo D, Guitart X. Effect of the novelsigma1 receptor ligand and putative atypical antipsychotic E-5842 on BDNF mRNAexpression in the rat brain. Neuroreport. 2002 Dec 3;13(17):2345-8. PubMed PMID:12488824.

6: Ovalle S, Zamanillo D, Andreu F, Farré AJ, Guitart X. Fibroblast growthfactor-2 is selectively modulated in the rat brain by E-5842, a preferentialsigma-1 receptor ligand and putative atypical antipsychotic. Eur J Neurosci. 2001Mar;13(5):909-15. PubMed PMID: 11264663.7: Beckett S. E-5842 (Laboratories Dr Esteve). IDrugs. 2000 Jun;3(6):666-8.PubMed PMID: 16096930.8: Sánchez-Arroyos R, Guitart X. Electrophysiological effects of E-5842, a sigma1receptor ligand and potential atypical antipsychotic, on A9 and A10 dopamineneurons. Eur J Pharmacol. 1999 Jul 28;378(1):31-7. PubMed PMID: 10478562.9: Guitart X, Farré AJ. The effect of E-5842, a sigma receptor ligand andpotential atypical antipsychotic, on Fos expression in rat forebrain. Eur JPharmacol. 1998 Dec 18;363(2-3):127-30. PubMed PMID: 9881578.10: Guzmán A, García C, Marín AP, Tortajada A, Ruiz MT, Fernández de HenestrosaAR, Marcos R. Formation of micronucleated erythrocytes in mouse bone-marrow underconditions of hypothermia is not associated with stimulation of erythropoiesis.Mutat Res. 2008 Oct 30;656(1-2):8-13. doi: 10.1016/j.mrgentox.2008.06.016. PubMedPMID: 18718553.1

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