1356918-39-2|DS-8587|7-((3aR,6aS)-3a-amino-6a-fluorohexahydrocyclopenta[c]pyrrol-2(1H)-yl)-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride dihydrate|-范德生物科技公司

DS-8587

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names：
7-((3aR,6aS)-3a-amino-6a-fluorohexahydrocyclopenta[c]pyrrol-2(1H)-yl)-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride dihydrate
CAS号：
1356918-39-2
MDL Number：
MF(分子式)： C21H27ClF3N3O5 MW(分子量)： 493.9082
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	DS-8587
英文别名	DS-8587; DS8587; DS 8587; DS-8587 free
CAS号	1356918-39-2
Inchi	InChI=1S/C21H22F3N3O3.ClH.2H2O/c1-10-16-11(18(28)12(19(29)30)7-27(16)15-6-13(15)22)5-14(23)17(10)26-8-20(24)3-2-4-21(20,25)9-26;;;/h5,7,13,15H,2-4,6,8-9,25H2,1H3,(H,29,30);1H;2*1H2/t13-,15+,20-,21+;;;/m0.../s1
InchiKey	WDCLSNJDBKODOF-JNEZQIAFSA-N
分子式 Formula	C21H27ClF3N3O5
分子量 Molecular Weight	493.9082
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	DS-8587(CAS:1356918-39-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	DS-8587 is a DNA topoisomerase inhibitor potentially for the treatment of bacterial infection. DS-8587 significantly reduced the number of viable bacteria in a murine model of F. necrophorum-induced liver abscess. DS-8587 exhibits potent antibacterial activity against quinolone-resistant A. baumannii isolates that harbor mutations in quinolone resistance-determining regions. In the presence of the efflux pump inhibitor 1-(1-napthylmethyl)-piperazine, no significant changes were observed in the MIC for DS-8587.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Nagaoka K, Yanagihara K, Morinaga Y, Kurosaka Y, Hoshino K, Kohno S. In vivo antianaerobe activity of DS-8587, a new fluoroquinolone, against Fusobacterium necrophorum in a mouse model. J Infect Chemother. 2017 Mar;23(3):131-135. doi: 10.1016/j.jiac.2016.09.007. PubMed PMID: 28109739.

[2]Higuchi S, Shikata M, Chiba M, Hoshino K, Gotoh N. Characteristics of antibiotic resistance and sequence type of Acinetobacter baumannii clinical isolates in Japan and the antibacterial activity of DS-8587. J Infect Chemother. 2014 Apr;20(4):256-61. doi: 10.1016/j.jiac.2013.12.001. PubMed PMID: 24709045.

[3] Higuchi S, Kurosaka Y, Uoyama S, Yoshida K, Chiba M, Ishii C, Fujikawa K, Karibe Y, Hoshino K. Anti-multidrug-resistant Acinetobacter baumannii activity of DS-8587: In vitro activity and in vivo efficacy in a murine calf muscle infection model. J Infect Chemother. 2014 May;20(5):312-6. doi: 10.1016/j.jiac.2014.01.011. PubMed PMID: 24594453.

[4] Higuchi S, Onodera Y, Chiba M, Hoshino K, Gotoh N. Potent in vitro antibacterial activity of DS-8587, a novel broad-spectrum quinolone, against Acinetobacter baumannii. Antimicrob Agents Chemother. 2013 Apr;57(4):1978-81. doi: 10.1128/AAC.02374-12. PubMed PMID: 23380726; PubMed Central PMCID: PMC3623304.

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