400647-59-8|Doxorubicin-SMCC|4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)-N-((2S,3S,4S,6R)-3-hydroxy-2-methyl-6-(((1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)cyclohexanecarboxamide|-范德生物科技公司

Doxorubicin-SMCC

NMR下载 COA and HPLC MSDS下载
names：
4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)-N-((2S,3S,4S,6R)-3-hydroxy-2-methyl-6-(((1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)cyclohexanecarboxamide
CAS号：
400647-59-8
MDL Number：
MF(分子式)： C39H42N2O14 MW(分子量)： 762.76
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Doxorubicin-SMCC
英文别名	Doxorubicin-SMCC; ADR-SMCC; Dox-SMCC Doxo-SMCC.
CAS号	400647-59-8
Inchi	InChI=1S/C39H42N2O14/c1-17-33(46)22(40-38(51)19-8-6-18(7-9-19)15-41-26(44)10-11-27(41)45)12-28(54-17)55-24-14-39(52,25(43)16-42)13-21-30(24)37(50)32-31(35(21)48)34(47)20-4-3-5-23(53-2)29(20)36(32)49/h3-5,10-11,17-19,22,24,28,33,42,46,48,50,52H,6-9,12-16H2,1-2H3,(H,40,51)/t17-,18?,19?,22-,24-,28-,33+,39-/m0/s1
InchiKey	OTQOQHVWNBKSGU-SAJDXUNTSA-N
分子式 Formula	C39H42N2O14
分子量 Molecular Weight	762.76
溶解度Solubility
性状	Red solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Doxorubicin-SMCC(CAS:400647-59-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Doxorubicin-SMCC, also known as ADR-SMCC, dox-SMCC, is a derivative of doxorubicin with a SMCC linker (Succinimidyl-4-( N -maleimidomethyl)cyclohexane-1-carboxylate). Maleimide in doxrubicin-SMCC can react with sulfhydryl groups at pH 6.5-7.5 to form a stable thioether bond. Doxorubicin-SMCC can be used to synthesize doxorubicin bioconjugates with proteins, enzymes; antobodies, antigens, and other biopolymers. Doxorubicin-SMCC is often used for drug delivery research.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

2: A Flow Cytometric Clonogenic Assay Reveals the Single-Cell Potency of Doxorubicin Katie F. Maass, Chethana Kulkarni, Mohiuddin A. Quadir, Paula T. Hammond, Alison M. Betts, K. Dane Wittrup J Pharm Sci. Author manuscript; available in PMC 2016 Dec 1.Published in final edited form as: J Pharm Sci. 2015 Dec; 104(12): 4409–4416. Published online 2015 Sep 7. doi: 10.1002/jps.24631 PMCID: PMC4706798