28832-07-7|Dicentrine, (-)-|(R)-10,11-dimethoxy-7-methyl-6,7,7a,8-tetrahydro-5H-[1,3]dioxolo[4',5'4,5]benzo[1,2,3-de]benzo[g]quinoline|-范德生物科技公司

Dicentrine, (-)-

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names：
(R)-10,11-dimethoxy-7-methyl-6,7,7a,8-tetrahydro-5H-[1,3]dioxolo[4',5'4,5]benzo[1,2,3-de]benzo[g]quinoline
CAS号：
28832-07-7
MDL Number：
MF(分子式)： C20H21NO4 MW(分子量)： 339.39
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Dicentrine, (-)-
英文别名	Dicentrine, (-)-; L-Dicentrine; NSC-251699; NSC 251699; NSC251699;
CAS号	28832-07-7
SMILES	CN1CCC(C2=C3C4=CC(OC)=C(OC)C=C4C[C@@]12[H])=CC5=C3OCO5
Inchi	InChI=1S/C20H21NO4/c1-21-5-4-11-7-17-20(25-10-24-17)19-13-9-16(23-3)15(22-2)8-12(13)6-14(21)18(11)19/h7-9,14H,4-6,10H2,1-3H3/t14-/m1/s1
InchiKey	YJWBWQWUHVXPNC-CQSZACIVSA-N
分子式 Formula	C20H21NO4
分子量 Molecular Weight	339.39
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Dicentrine, (-)-(CAS:28832-07-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Dicentrine, (-)- is an aporphinic alkaloid found in several plant species, mainly from Lauraceae family, which showed significant antinociceptive activity in an acute model of visceral pain in mice. It has also been shown to reduce spontaneous nociception and attenuating mechanical and cold hypersensitivity, probably via a TRPA1-dependent mechanism.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Tiwari S, Awasthi M, Singh S, Pandey VP, Dwivedi UN. Modulation of interaction of mutant TP53 and wild type BRCA1 by alkaloids: a computational approach towards targeting protein-protein interaction as a futuristic therapeutic intervention strategy for breast cancer impediment. J Biomol Struct Dyn. 2017 Oct 2

3:1-12. doi: 10.1080/07391102.2017.1388286. [Epub ahead of print] PubMed PMID: 28978265.

[3]Ma P, Li T, Ji F, Wang H, Pang J. Effect of GABA on blood pressure and blood dynamics of anesthetic rats. Int J Clin Exp Med. 2015 Aug 15;8(8):14296-302. eCollection 2015. PubMed PMID: 26550413; PubMed Central PMCID: PMC4613098.

[4]Lin HF, Huang HL, Liao JF, Shen CC, Huang RL. Dicentrine Analogue-Induced G2/M Arrest and Apoptosis through Inhibition of Topoisomerase II Activity in Human Cancer Cells. Planta Med. 2015 Jul;81(10):830-7. doi: 10.1055/s-0035-1546128. Epub 2015 Jul 9. PubMed PMID: 26158522.

[5] Dong JW, Cai L, Fang YS, Xiao H, Li ZJ, Ding ZT. Proaporphine and aporphine alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea. Fitoterapia. 2015 Jul;10

4:102-7. doi: 10.1016/j.fitote.2015.05.019. Epub 2015 May 29. PubMed PMID: 26028544.

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