132245-57-9|Dexamethasone cipecilate|2-((8S,9R,10S,11S,13S,14S,16R,17R)-17-((cyclopropanecarbonyl)oxy)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl cyclohexanecarboxylate|-范德生物科技公司

Dexamethasone cipecilate

NMR下载 COA and HPLC MSDS下载
names：
2-((8S,9R,10S,11S,13S,14S,16R,17R)-17-((cyclopropanecarbonyl)oxy)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl cyclohexanecarboxylate
CAS号：
132245-57-9
MDL Number：
MF(分子式)： C33H43FO7 MW(分子量)： 570.6984
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Dexamethasone cipecilate
英文别名	Dexamethasone cipecilate; NS-126; NS 126; NS126.
CAS号	132245-57-9
Inchi	InChI=1S/C33H43FO7/c1-19-15-25-24-12-11-22-16-23(35)13-14-30(22,2)32(24,34)26(36)17-31(25,3)33(19,41-29(39)21-9-10-21)27(37)18-40-28(38)20-7-5-4-6-8-20/h13-14,16,19-21,24-26,36H,4-12,15,17-18H2,1-3H3/t19-,24+,25+,26+,30+,31+,32+,33+/m1/s1
InchiKey	JPTKVJWWVFLEJL-GVPGRCOTSA-N
分子式 Formula	C33H43FO7
分子量 Molecular Weight	570.6984
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Dexamethasone cipecilate(CAS:132245-57-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Dexamethasone cipecilate, also known as NS-126, is a novel, highly lipophilic anti-inflammatory corticosteroid. NS-126 is a long-acting intranasal corticosteroid and a promising therapeutic agent for allergic rhinitis.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Sasagawa T, Yamada T, Nakagawa T, Tsujioka T, Takahashi Y, Kawakita N, Nonaka K, Nakamura A. In vitro metabolism of dexamethasone cipecilate, a novel synthetic corticosteroid, in human liver and nasal mucosa. Xenobiotica. 2011 Oct;41(10):874-84. doi: 10.3109/00498254.2011.582894. Epub 2011 Jun 10. PubMed PMID: 21657966.

[2]Yu SQ, Wang DH. Enhanced salt sensitivity following shRNA silencing of neuronal TRPV1 in rat spinal cord. Acta Pharmacol Sin. 2011 Jun;32(6):845-52. doi: 10.1038/aps.2011.43. PubMed PMID: 21642952; PubMed Central PMCID: PMC4009958.

[3] Gotoh M, Okubo K, Okuda M, Hamada C. Clinical pharmacology study of the corticosteroid nasal spray dexamethasone cipecilate (NS-126): examination of the durability of efficacy in the nasal induction test. Expert Opin Investig Drugs. 2010 Dec;19(12):1475-86. doi: 10.1517/13543784.2010.531258. Epub 2010 Nov 11. PubMed PMID: 21067470.

[4] Inoue N, Hashino A, Kageyama K, Zhang X, Sasagawa T, Kawakita N, Takahashi Y, Yoshida K, Hashimoto M, Mori K, Kyoi T. Pharmacological profile of the novel anti-inflammatory corticosteroid NS-126, a therapeutic agent for allergic rhinitis. J Pharmacol Sci. 2010;112(1):73-82. Epub 2010 Jan 6. PubMed PMID: 20051657.

[5] Pech V, Sikka SC, Sindhu RK, Vaziri ND, Majid DS. Oxidant stress and blood pressure responses to angiotensin II administration in rats fed varying salt diets. Am J Hypertens. 2006 May;19(5):534-40. PubMed PMID: 16647629.

6: Etaugh C, Kelliher R, Osborne B, Rose M. The role of visual and haptic cues in children's discrimination learning. J Genet Psychol. 1981 Mar;138(1st Half):75-9. PubMed PMID: 7217924.

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