3600-87-1|Desglymidodrine|alpha-(Aminomethyl)-2,5-dimethoxybenzenemethanol|-范德生物科技公司

Desglymidodrine

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names：
alpha-(Aminomethyl)-2,5-dimethoxybenzenemethanol
CAS号：
3600-87-1
MDL Number：
MF(分子式)： C10H15NO3 MW(分子量)： 197.23
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Desglymidodrine
英文别名	Desglymidodrine
CAS号	3600-87-1
SMILES	OC(CN)C1=CC(OC)=CC=C1OC
Inchi	InChI=1S/C10H15NO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5,9,12H,6,11H2,1-2H3
InchiKey	VFRCNXKYZVQYLX-UHFFFAOYSA-N
分子式 Formula	C10H15NO3
分子量 Molecular Weight	197.23
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Desglymidodrine(CAS:3600-87-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Desglymidodrine is a Metabolite of midodrine (ST-1085). It is used in plasma of ascitic patients.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Ali AA, Al-Ghobashy MA, Farid SF, Kassem MA. Development and validation of LC-MS/MS assay for the determination of the prodrug Midodrine and its active metabolite Desglymidodrine in plasma of ascitic patients: Application to individualized therapy and comparative pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jun 1;991:34-40. doi: 10.1016/j.jchromb.2015.03.032. Epub 2015 Apr 7. PubMed PMID: 25910235.

[2]Barth T, Aleu J, Pupo MT, Bonato PS, Collado IG. HPLC analysis of midodrine and desglymidodrine in culture medium: evaluation of static and shaken conditions on the biotransformation by fungi. J Chromatogr Sci. 2013 May-Jun;51(5):460-7. doi: 10.1093/chromsci/bms163. Epub 2012 Oct 9. PubMed PMID: 23051063.

[3] Patel DP, Nair S, Suhagia BN, Patel BM. A novel, sensitive and selective method of UPLC/MS-MS for rapid simultaneous determination of midodrine and its active metabolite desglymidodrine in human plasma: Application to support bioequivalence study in healthy human volunteers. J Pharm Biomed Anal. 2016 Nov 30;131:355-363. doi: 10.1016/j.jpba.2016.09.005. Epub 2016 Sep 5. PubMed PMID: 27639073.

[4] Ali A, Farid S, Amin M, Kassem M, Al-Garem N, Al-Ghobashy M. Comparative Clinical Pharmacokinetics of Midodrine and Its Active Metabolite Desglymidodrine in Cirrhotic Patients with Tense Ascites Versus Healthy Volunteers. Clin Drug Investig. 2016 Feb;36(2):147-55. doi: 10.1007/s40261-015-0359-6. PubMed PMID: 26597181.

[5] Barth T, Pupo MT, Borges KB, Okano LT, Bonato PS. Stereoselective determination of midodrine and desglymidodrine in culture medium: application to a biotransformation study employing endophytic fungi. Electrophoresis. 2010 May;31(9):1521-8. doi: 10.1002/elps.200900685. PubMed PMID: 20376815.

6: Akimoto M, Iida I, Itoga H, Miyata A, Kawahara S, Kohno Y. The in vitro metabolism of desglymidodrine, an active metabolite of prodrug midodrine by human liver microsomes. Eur J Drug Metab Pharmacokinet. 2004 Jul-Sep;29(3):179-86. PubMed PMID: 15537169.7: Biaggioni I. New developments in the management of neurogenic orthostatic hypotension. Curr Cardiol Rep. 2014 Nov;16(11):542. doi: 10.1007/s11886-014-0542-z. Review. PubMed PMID: 25303896.8: Leduc BE, Fournier C, Jacquemin G, Lepage Y, Vinet B, Hétu PO, Chagnon M. Midodrine in patients with spinal cord injury and anejaculation: A double-blind randomized placebo-controlled pilot study. J Spinal Cord Med. 2015 Jan;38(1):57-62. doi: 10.1179/2045772314Y.0000000225. Epub 2014 Jun 26. PubMed PMID: 24969635; PubMed Central PMCID: PMC4293534.9: Wright RA, Kaufmann HC, Perera R, Opfer-Gehrking TL, McElligott MA, Sheng KN, Low PA. A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension. Neurology. 1998 Jul;51(1):120-4. PubMed PMID: 9674789.10: Perazella MA. Efficacy and safety of midodrine in the treatment of dialysis-associated hypotension. Expert Opin Drug Saf. 2003 Jan;2(1):37-47. Review. PubMed PMID: 12904123.1

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