169285-98-7|DA 1131|(4R,5S)-6-(1-hydroxyethyl)-4-methyl-3-(((3S,5S)-5-((E)-3-(methylsulfonamido)prop-1-en-1-yl)pyrrolidin-3-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid|-范德生物科技公司

DA 1131

NMR下载 COA and HPLC MSDS下载
names：
(4R,5S)-6-(1-hydroxyethyl)-4-methyl-3-(((3S,5S)-5-((E)-3-(methylsulfonamido)prop-1-en-1-yl)pyrrolidin-3-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
CAS号：
169285-98-7
MDL Number：
MF(分子式)： C18H27N3O6S2 MW(分子量)： 445.55
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	DA 1131
英文别名	DA 1131; DA-1131; DA1131;
CAS号	169285-98-7
Inchi	InChI=1S/C18H27N3O6S2/c1-9-14-13(10(2)22)17(23)21(14)15(18(24)25)16(9)28-12-7-11(19-8-12)5-4-6-20-29(3,26)27/h4-5,9-14,19-20,22H,6-8H2,1-3H3,(H,24,25)/b5-4+/t9-,10?,11-,12+,13?,14-/m1/s1
InchiKey	UXCCOLVNQUBDAJ-FGQVXFQSSA-N
分子式 Formula	C18H27N3O6S2
分子量 Molecular Weight	445.55
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	DA 1131(CAS:169285-98-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	DA 1131 is a new carbapenem antibiotic, undergoes renal metabolism by renal dehydropeptidase I (DHP-I), located on the brush border of the proximal tubular cell. Species differences with the effects of cilastatin, a renal DHP-I inhibitor, after a 1-min intravenous infusion of DA-1131, with or without cilastatin, to rats, rabbits, and dogs.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kim SH, Kim WB, Lee MG. Effect of probenecid on the renal excretion mechanism of a new carbapenem, DA-1131, in rats and rabbits. Antimicrob Agents Chemother. 1999 Jan;43(1):96-9. PubMed PMID: 9869572; PubMed Central PMCID: PMC89027.

[2]Kim SH, Shim HJ, Kim WB, Lee MG. Pharmacokinetics of a new carbapenem, DA-1131, after intravenous administration to rats with uranyl nitrate-induced acute renal failure. Antimicrob Agents Chemother. 1998 May;42(5):1217-21. PubMed PMID: 9593153; PubMed Central PMCID: PMC105781.

[3] Kim SH, Kwon JW, Lee MG. Pharmacokinetics and tissue distribution of a new carbapenem DA-1131, after intravenous administration to mice, rats, rabbits and dogs. Biopharm Drug Dispos. 1998 May;19(4):219-29. PubMed PMID: 9604121.

[4] Kim SH, Kwon JW, Kim WB, Lee MG. Effects of cilastatin on the pharmacokinetics of a new carbapenem, DA-1131, in rats, rabbits, and dogs. Antimicrob Agents Chemother. 1999 Oct;43(10):2524-7. PubMed PMID: 10508037; PubMed Central PMCID: PMC89513.

[5] Kim SH, Kim WB, Lee MG. Pharmacokinetics of a new carbapenem, DA-1131, after intravenous administration to rats with alloxan-induced diabetes mellitus. Biopharm Drug Dispos. 1998 Jul;19(5):303-8. PubMed PMID: 9673782.

6: Park SW, We JS, Kim GW, Choi SH, Park HS. Stability of new carbapenem DA-1131 to renal dipeptidase (dehydropeptidase I). Antimicrob Agents Chemother. 2002 Feb;46(2):575-7. PubMed PMID: 11796382; PubMed Central PMCID: PMC127065.7: Kim SH, Kim WB, Kwon JW, Lee MG. Nephroprotective effect of betamipron on a new carbapenem, DA-1131, in rabbits. Biopharm Drug Dispos. 1999 Apr;20(3):125-9. PubMed PMID: 10211864.8: Kim SH, Kim WB, Lee MG. No effect of probenecid on the renal excretion mechanism of a new carbapenem, DA-1131, in dogs. Res Commun Mol Pathol Pharmacol. 1998 Jul;101(1):85-92. PubMed PMID: 9755846.9: Kim SH, Kwon JW, Kim WB, Lee I, Lee MG. Effects of water deprivation for 72 hours on the pharmacokinetics of a new carbapenem, DA-1131, in rats. Life Sci. 2002 Sep 27;71(19):2291-8. PubMed PMID: 12215376.10: Kim SH, Kim WB, Lee MG. Interspecies pharmacokinetic scaling of a new carbapenem, DA-1131, in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics. Biopharm Drug Dispos. 1998 May;19(4):231-5. PubMed PMID: 9604122.1

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开