157542-49-9|CS 834|( )-(Pivaloyloxymethyl(4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-3-(((R)-5-oxopyrrolidin-3-yl)thio)- 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylate|-范德生物科技公司

CS 834

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names：
( )-(Pivaloyloxymethyl(4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-3-(((R)-5-oxopyrrolidin-3-yl)thio)- 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylate
CAS号：
157542-49-9
MDL Number：
MF(分子式)： C20H28N2O7S MW(分子量)： 440.51
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	CS 834
英文别名	CS 834; CS834; CS-834; UNII-H26S03B779.
CAS号	157542-49-9
Inchi	InChI=1S/C20H28N2O7S/c1-9-14-13(10(2)23)17(25)22(14)15(16(9)30-11-6-12(24)21-7-11)18(26)28-8-29-19(27)20(3,4)5/h9-11,13-14,23H,6-8H2,1-5H3,(H,21,24)/t9-,10-,11-,13-,14-/m1/s1
InchiKey	ZNOVVAJWYUBFMI-JIFFNSBPSA-N
分子式 Formula	C20H28N2O7S
分子量 Molecular Weight	440.51
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	CS 834(CAS:157542-49-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	CS 834 is a novel oral carbapenem antibiotic. It is an ester-type prodrug of the active metabolite R-95867.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]van Ogtrop ML. CS-834 (Sankyo). IDrugs. 1999 Mar;2(3):254-8. PubMed PMID: 16160937.

[2]Kobayashi K, Fukuhara H, Hata T, Ohashi Y. In situ observation of the four-step dehydration process of the 1 beta-methylcarbapenem antibiotic CS-834 crystal by X-rays. Chem Pharm Bull (Tokyo). 2003 Dec;51(12):1356-62. PubMed PMID: 14646309.

[3] Kobayashi K, Fukuhara H, Kawamoto I, Hata T, Sekine A, Uekusa H, Ohashi Y. Physicochemical analyses of phase transition and dehydration processes of a new oral 1beta-methylcarbapenem antibiotic agent, CS-834. Chem Pharm Bull (Tokyo). 2002 Dec;50(12):1570-3. PubMed PMID: 12499592.

[4] Kobayashi K, Fukuhara H, Kawamoto I, Ito S, Hata T. Crystal structure of a 1beta-methylcarbapenem antibiotic, pivaloyloxymethyl (1R,5S,6S)-6-[(R)-1-hydroxyethyl]-1-methyl-2-[[(R)-5-oxopyrrolidin-3-yl]thio]-1-c arbapen-2-em-3-carboxylate, CS-834 dihydrate. Anal Sci. 2001 Feb;17(2):357-8. PubMed PMID: 11990557.

[5] Bonfiglio G, Russo G, Nicoletti G. Recent developments in carbapenems. Expert Opin Investig Drugs. 2002 Apr;11(4):529-44. Review. PubMed PMID: 11922861.

6: Sader HS, Gales AC. Emerging strategies in infectious diseases: new carbapenem and trinem antibacterial agents. Drugs. 2001;61(5):553-64. Review. PubMed PMID: 11368281.7: Liu CX, Kato N, Watanabe K, Sakata T, Kaneko T. Impact of a new quinolone, DU-6859a, and two oral carbapenems, CS-834 and L-084, on the rat and mouse caecal microflora. J Antimicrob Chemother. 2000 Nov;46(5):823-6. PubMed PMID: 11062207.8: Mouton JW, Touzw DJ, Horrevorts AM, Vinks AA. Comparative pharmacokinetics of the carbapenems: clinical implications. Clin Pharmacokinet. 2000 Sep;39(3):185-201. Review. PubMed PMID: 11020134.9: Okuda J, Otsuki M, Oh T, Nishino T. In vitro activity of DU-6681a, an active form of the new oral carbapenem compound DZ-2640, in comparison with that of R-95867, faropenem and oral cephalosporins. J Antimicrob Chemother. 2000 Jul;46(1):101-8. PubMed PMID: 10882697.10: Mori M, Oida S. A short-step synthesis of orally active carbapenem antibiotic CS-834. Chem Pharm Bull (Tokyo). 2000 Jan;48(1):126-30. PubMed PMID: 10705488.1

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