104786-63-2|CH-38083|6H-Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizin-11-ol, 5,8,8a,9,10,11,12,12a,13,13a-decahydro-, hydrochloride, (8aS-(8aalpha,11alpha,12aalpha,13aalpha))-|-范德生物科技公司

CH-38083

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names：
6H-Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizin-11-ol, 5,8,8a,9,10,11,12,12a,13,13a-decahydro-, hydrochloride, (8aS-(8aalpha,11alpha,12aalpha,13aalpha))-
CAS号：
104786-63-2
MDL Number：
MF(分子式)： C18H24ClNO3 MW(分子量)： 337.844
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	CH-38083
英文别名	CH38083; CH 38083; CH-38083
CAS号	104786-63-2
Inchi	InChI=1S/C18H23NO3.ClH/c20-14-2-1-12-9-19-4-3-11-7-17-18(22-10-21-17)8-15(11)16(19)6-13(12)5-14;/h7-8,12-14,16,20H,1-6,9-10H2;1H/t12-,13+,14+,16+;/m1./s1
InchiKey	MSHVJMFWPHDENI-AFHKOZSWSA-N
分子式 Formula	C18H24ClNO3
分子量 Molecular Weight	337.844
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	CH-38083(CAS:104786-63-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	CH-38083 is a selective, potent antagonist of alpha-2 adrenoceptors.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Vizi ES, Zsilla G, Caron MG, Kiss JP. Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors. J Neurosci. 2004 Sep 8;24(36):7888-94. PubMed PMID: 15356201.

[2]Selmeczy Z, Szelényi J, Vizi ES. Intact noradrenaline transporter is needed for the sympathetic fine-tuning of cytokine balance. Eur J Pharmacol. 2003 May 23;469(1-3):175-81. PubMed PMID: 12782200.

[3] Vizi ES, Katona I, Freund TF. Evidence for presynaptic cannabinoid CB(1) receptor-mediated inhibition of noradrenaline release in the guinea pig lung. Eur J Pharmacol. 2001 Nov 16;431(2):237-44. PubMed PMID: 11728431.

[4] Vizi ES, Szelényi J, Selmeczy ZS, Papp Z, Németh ZH, Haskó G. Enhanced tumor necrosis factor-alpha-specific and decreased interleukin-10-specific immune responses to LPS during the third trimester of pregnancy in mice. J Endocrinol. 2001 Nov;171(2):355-61. PubMed PMID: 11691656.

[5] Banik RK, Sato J, Yajima H, Mizumura K. Differences between the Lewis and Sprague-Dawley rats in chronic inflammation induced norepinephrine sensitivity of cutaneous C-fiber nociceptors. Neurosci Lett. 2001 Feb 16;299(1-2):21-4. PubMed PMID: 11166928.

6: Taoda M, Adachi YU, Uchihashi Y, Watanabe K, Satoh T, Vizi ES. Effect of dexmedetomidine on the release of [3H]-noradrenaline from rat kidney cortex slices: characterization of alpha2-adrenoceptor. Neurochem Int. 2001 Apr;38(4):317-22. PubMed PMID: 11137626.7: Szelényi J, Kiss JP, Puskás E, Selmeczy Z, Szelényi M, Vizi ES. Opposite role of alpha2- and beta-adrenoceptors in the modulation of interleukin-10 production in endotoxaemic mice. Neuroreport. 2000 Nov 9;11(16):3565-8. PubMed PMID: 11095519.8: Gyires K, Müllner K, Fürst S, Rónai AZ. Alpha-2 adrenergic and opioid receptor-mediated gastroprotection. J Physiol Paris. 2000 Mar-Apr;94(2):117-21. PubMed PMID: 10791692.9: Szelényi J, Kiss JP, Vizi ES. Differential involvement of sympathetic nervous system and immune system in the modulation of TNF-alpha production by alpha2- and beta-adrenoceptors in mice. J Neuroimmunol. 2000 Feb 1;103(1):34-40. PubMed PMID: 10674987.10: Sperlágh B, Sershen H, Lajtha A, Vizi ES. Co-release of endogenous ATP and [3H]noradrenaline from rat hypothalamic slices: origin and modulation by alpha2-adrenoceptors. Neuroscience. 1998 Jan;82(2):511-20. PubMed PMID: 9466457.1

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