238074-89-0|CH-1504|2-(4-(2-(2,4-diaminoquinazolin-6-yl)ethyl)benzamido)-4-methylenepentanedioic acid|-范德生物科技公司

CH-1504

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names：
2-(4-(2-(2,4-diaminoquinazolin-6-yl)ethyl)benzamido)-4-methylenepentanedioic acid
CAS号：
238074-89-0
MDL Number：
MF(分子式)： C23H23N5O5 MW(分子量)： 449.47
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	CH-1504
英文别名	MobileTrex; CH-1504; CH1504; CH 1504;
CAS号	238074-89-0
Inchi	InChI=1S/C23H23N5O5/c1-12(21(30)31)10-18(22(32)33)26-20(29)15-7-4-13(5-8-15)2-3-14-6-9-17-16(11-14)19(24)28-23(25)27-17/h4-9,11,18H,1-3,10H2,(H,26,29)(H,30,31)(H,32,33)(H4,24,25,27,28)
InchiKey	NAWXUBYGYWOOIX-UHFFFAOYSA-N
分子式 Formula	C23H23N5O5
分子量 Molecular Weight	449.47
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	CH-1504(CAS:238074-89-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	CH-1504, also known as MobileTrex, is dihydrofolate reductase (DHFR) inhibitor potentially for the treatment of rheumatoid arthritis.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Keystone EC, Shirinsky VS, Simon LS, Pedder S, Hewitt LA; CH-1504 Study Group.. Efficacy and safety of CH-1504, a metabolically stable antifolate, in patients with active rheumatoid arthritis: results of a phase II multicenter randomized study. J Rheumatol. 2011 Sep;38(9):1875-83. doi: 10.3899/jrheum.101038. PubMed PMID: 21724705.

[2]Bajpai M. CH-1504, a metabolically inert antifolate for the potential treatment of rheumatoid arthritis. IDrugs. 2010 Aug;13(8):559-67. Review. PubMed PMID: 20721827.

[3] McGuire JJ, Haile WH. Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4'-methyleneglutamic acid (CH-1504) and its analogs. Biochem Pharmacol. 2009 Apr 1;77(7):1161-72. doi: 10.1016/j.bcp.2008.12.020. PubMed PMID: 19174154.

[4] Mant T, Jurcevic S, Szakacs C, Adams L, Boland J, Hewitt LA. Two single-center, double-blind, randomized, placebo-controlled, phase I studies to investigate the tolerability and pharmacokinetics of CH-1504, an antifolate, in healthy male subjects. Clin Ther. 2008 Jan;30(1):131-42. doi: 10.1016/j.clinthera.2008.01.017. PubMed PMID: 18343249.

[5] Castaneda O, Nair MG. Controlled trial of methotrexate versus CH-1504 in the treatment of rheumatoid arthritis. J Rheumatol. 2006 May;33(5):862-4. PubMed PMID: 16652417.

6: Antoniu SA. Discontinued drugs 2010: rheumatology, allergy and dermatology, pulmonary. Expert Opin Investig Drugs. 2011 Sep;20(9):1175-87. doi: 10.1517/13543784.2011.599800. Review. PubMed PMID: 21793791.7: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2006 Dec;28(10):719-40. PubMed PMID: 17235418.

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