150379-37-6|Cgp 43182|1,5-Dioxaspiro(5.5)undec-2-ene-3-carboxamide, N-(2,3-dichlorophenyl)-2-hydroxy-4-oxo-|-范德生物科技公司

Cgp 43182

NMR下载 COA and HPLC MSDS下载
names：
1,5-Dioxaspiro(5.5)undec-2-ene-3-carboxamide, N-(2,3-dichlorophenyl)-2-hydroxy-4-oxo-
CAS号：
150379-37-6
MDL Number：
MF(分子式)： C16H15Cl2NO5 MW(分子量)： 372.2
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	Cgp 43182
英文别名	Cgp 43182; Cgp-43182; Cgp43182.
CAS号	150379-37-6
Inchi	InChI=1S/C16H15Cl2NO5/c17-9-5-4-6-10(12(9)18)19-13(20)11-14(21)23-16(24-15(11)22)7-2-1-3-8-16/h4-6,21H,1-3,7-8H2,(H,19,20)
InchiKey	KSXVYLXVMKLSOE-UHFFFAOYSA-N
分子式 Formula	C16H15Cl2NO5
分子量 Molecular Weight	372.2
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Cgp 43182(CAS:150379-37-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Cgp 43182 is a potent inhibitor of group IIA secreted phospholipase A2 (group IIA sPLA2) activity in vitro. Cgp 43182 is a potent anti-inflammatory drug useful for preventing the consequences of a concerted action of cytokine-stimulated pro-inflammatory genes mediated by NFkappaB.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kumar KN, Johnson PS, Chen X, Pal R, Ahmad M, Ragland T, Bigge C, Michaelis EK. Cloning of a brain N-methyl-D-aspartate- and D, L-epsilon-2-amino-4-propyl-5-phosphono-3-pentanoic acid (CGP 39653)-binding protein. Biochem Biophys Res Commun. 1998 Dec 18;253(2):463-9. PubMed PMID: 9878559.

[2]Mugnaini M, van Amsterdam FT, Ratti E, Trist DG, Bowery NG. Regionally different N-methyl-D-aspartate receptors distinguished by ligand binding and quantitative autoradiography of [3H]-CGP 39653 in rat brain. Br J Pharmacol. 1996 Nov;119(5):819-28. PubMed PMID: 8922727; PubMed Central PMCID: PMC1915925.

[3] White BH, Vogel MW. CGP 39653 binding in the chick CNS after NMDA receptor antagonist treatment. J Neural Transm (Vienna). 1996;103(11):1247-53. PubMed PMID: 9013411.

[4] Balcar VJ, Dias LS, Li Y, Bennett MR. Inhibition of [3H]CGP 39653 binding to NMDA receptors by a P2 antagonist, suramin. Neuroreport. 1995 Dec 29;7(1):69-72. PubMed PMID: 8742419.

[5] Banks MD, Sandberg MP, Fowler CJ. Pharmacological characterization of the N-methyl-D-aspartate (NMDA) receptor recognition site in porcine cerebral cortical membranes using [3H]-CGP 39653. Comp Biochem Physiol A Physiol. 1995 May;111(1):39-46. PubMed PMID: 7735908.

6: Balcar VJ, Li Y, Killinger S. Effects of L-trans-pyrrolidine-2,4-dicarboxylate and L-threo-3-hydroxyaspartate on the binding of [3H]L-aspartate, [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), [3H]DL-(E)-2-amino-4-propyl-5-phosphono-3-pentenoate (CGP 39653), [3H]6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and [3H]kainate studied by autoradiography in rat forebrain. Neurochem Int. 1995 Feb;26(2):155-64. PubMed PMID: 7541266.7: Dumont M, Lemaire S. Dynorphin potentiation of [3H]CGP-39653 binding to rat brain membranes. Eur J Pharmacol. 1994 Dec 12;271(1):241-4. PubMed PMID: 7698209.8: Reynolds IJ. [3H]CGP 39653 binding to the agonist site of the N-methyl-D-aspartate receptor is modulated by Mg2+ and polyamines independently of the arcaine-sensitive polyamine site. J Neurochem. 1994 Jan;62(1):54-62. PubMed PMID: 7903355.9: Mugnaini M, Giberti A, Ratti E, van Amsterdam FT. Allosteric modulation of [3H]CGP 39653 binding by glycine in rat brain. J Neurochem. 1993 Oct;61(4):1492-7. PubMed PMID: 8104234.10: Mariangela S, Cristina GA, Cristina FM, Costantino M, Giovanni B. The degeneration of the excitatory climbing fibers enhances [3H]MK-801 and [3H]CGP 39653 binding sites in the rat cerebellar cortex. Neurosci Lett. 1992 Oct 26;146(1):45-7. PubMed PMID: 1361976.1

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开