120122-26-1|Ceronapril|(2S)-1-[(2S)-6-amino-2-[hydroxy(4-phenylbutyl)phosphoryl]oxyhexanoyl]pyrrolidine-2-carboxylic acid|-范德生物科技公司

Ceronapril

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names：
(2S)-1-[(2S)-6-amino-2-[hydroxy(4-phenylbutyl)phosphoryl]oxyhexanoyl]pyrrolidine-2-carboxylic acid
CAS号：
120122-26-1
MDL Number：
MF(分子式)： C21H33N2O6P MW(分子量)： 440.4768
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Ceronapril
英文别名	Ceronapril; SQ-29852; SQ29,852
CAS号	120122-26-1
Inchi	InChI=1S/C21H33N2O6P/c22-14-6-4-13-19(20(24)23-15-8-12-18(23)21(25)26)29-30(27,28)16-7-5-11-17-9-2-1-3-10-17/h1-3,9-10,18-19H,4-8,11-16,22H2,(H,25,26)(H,27,28)/t18-,19-/m0/s1
InchiKey	IFYLTXNCFVRALQ-OALUTQOASA-N
分子式 Formula	C21H33N2O6P
分子量 Molecular Weight	440.4768
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Ceronapril(CAS:120122-26-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Ceronapril is an angiotensin converting enzyme inhibitor that has been shown to retard the breakdown of central cholecystokinin.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Weiner I, Smith AD, Rawlins JN, Feldon J. A neuroleptic-like effect of ceronapril on latent inhibition. Neuroscience. 1992 Jul;49(2):307-15. PubMed PMID: 1359453.

[2]Cutler NR, Sramek JJ, Luna A, Mena I, Brass EP, Kurtz NM, Brennan JJ. Effect of the ACE inhibitor ceronapril on cerebral blood flow in hypertensive patients. Ann Pharmacother. 1996 Jun;30(6):578-82. PubMed PMID: 8792940.

[3] Weiner I, Tarrasch R, Hasson O, Forian R, Smith AD, Rawlins JN, Feldon J. The effects of chronic administration of ceronapril on the partial reinforcement extinction effect and latent inhibition in rats. Behav Pharmacol. 1994 Jun;5(3):306-314. PubMed PMID: 11224280.

[4] Chen BZ, Mendelsohn FA. Effect of acute and chronic administration of ceronapril on angiotensin converting enzyme in plasma, kidney, lung, brain regions and cerebrospinal fluid of rats. Neuropharmacology. 1992 Sep;31(9):929-35. PubMed PMID: 1331844.

[5] Tu JI, Brennan J, Stouffer B, Mantha S, Turabi N, Tsay HM. Radioimmunoassay for ceronapril, a new angiotensin-converting enzyme inhibitor, and its application to a pharmacokinetic study in healthy male volunteers. Ther Drug Monit. 1992 Jun;14(3):209-19. PubMed PMID: 1412607.

6: Matsuzaki K, Mukai M, Sumimoto T, Murakami E. Effects of ACE inhibitors versus calcium antagonists on left ventricular morphology and function in patients with essential hypertension. Hypertens Res. 1997 Mar;20(1):7-10. PubMed PMID: 9101306.7: Katahira K, Mikami H, Otsuka A, Moriguchi A, Kohara K, Higashimori K, Okuda N, Nagano M, Morishita R, Ogihara T. Differential control of vascular tone and heart rate by different amino acid neurotransmitters in the rostral ventrolateral medulla of the rat. Clin Exp Pharmacol Physiol. 1994 Jul;21(7):545-56. PubMed PMID: 7982287.8: Kohara K, Brosnihan KB, Ferrario CM. Angiotensin(1-7) in the spontaneously hypertensive rat. Peptides. 1993 Sep-Oct;14(5):883-91. PubMed PMID: 8284265.9: Costall B, Domeney AM, Gerrard PA, Horovitz ZP, Kelly ME, Naylor RJ, Tomkins DM. Effects of captopril and SQ29,852 on anxiety-related behaviours in rodent and marmoset. Pharmacol Biochem Behav. 1990 May;36(1):13-20. PubMed PMID: 2112256.10: Ranadive SA, Chen AX, Serajuddin AT. Relative lipophilicities and structural-pharmacological considerations of various angiotensin-converting enzyme (ACE) inhibitors. Pharm Res. 1992 Nov;9(11):1480-6. PubMed PMID: 1475237.1

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