140128-74-1|Cefmatilen|(6R,7R)-3-((((1H-1,2,3-triazol-4-yl)thio)methyl)thio)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid|-范德生物科技公司

Cefmatilen

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names：
(6R,7R)-3-((((1H-1,2,3-triazol-4-yl)thio)methyl)thio)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS号：
140128-74-1
MDL Number：
MF(分子式)： C15H14N8O5S4 MW(分子量)： 514.56
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Cefmatilen
英文别名	Cefmatilen; S 1090; S-1090; S1090;
CAS号	140128-74-1
Inchi	InChI=1S/C15H14N8O5S4/c16-15-18-5(2-30-15)8(21-28)11(24)19-9-12(25)23-10(14(26)27)6(3-29-13(9)23)31-4-32-7-1-17-22-20-7/h1-2,9,13,28H,3-4H2,(H2,16,18)(H,19,24)(H,26,27)(H,17,20,22)/b21-8-/t9-,13-/m1/s1
InchiKey	UEQVTKSAEXANEZ-YCRCPZNHSA-N
分子式 Formula	C15H14N8O5S4
分子量 Molecular Weight	514.56
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Cefmatilen(CAS:140128-74-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Cefmatilen is a compound being developed as a cephalosporin antibiotic for oral use.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Takeuchi M, Harada M, Nagata M, Watanabe A, Nakamura K. [Immunological properties of S-1090, cefmatilen hydrochloride hydrate]. J Toxicol Sci. 2001 May;26 Suppl 1:231-42. Japanese. PubMed PMID: 11400315.

[2]Yahara I, Furukawa H, Sato K, Nishimura K, Harihara A, Yabuuchi K, Miyauchi H, Kii Y, Muraoka Y, Kitamura T, Kato I. [Toxicity study of cefmatilen hydrochloride hydrate (S-1090) (1)--Single oral and intravenous dose toxicity studies in rats]. J Toxicol Sci. 2001 May;26 Suppl 1:1-4. Japanese. PubMed PMID: 11400306.

[3] Kishi K, Andou M, Muraoka Y, Ito M, Hara K, Yoshida T, Muranaka R, Kanamori S, Hirashiba M, Uchida H, Kawai M, Ikeuchi K, Hishikawa A, Kaneto M. [Reproductive and developmental toxicity studies of S-1090, cefmatilen hydrochloride hydrate (4)--A study on oral administration during the perinatal and lactation periods in rats]. J Toxicol Sci. 2001 May;26 Suppl 1:205-29. Japanese. PubMed PMID: 11400314.

[4] Sameshima H, Omori M, Nishimura Y, Chihaya Y, Itoh F, Mizushima Y, Yabuuchi K, Ohno K, Furukawa H, Yoshida I, Ueno M, Yahara I, Kato I. [Toxicity study of cefmatilen hydrochloride hydrate (S-1090) (5)--Six-month repeated oral dose toxicity study and supplement study in rats]. J Toxicol Sci. 2001 May;26 Suppl 1:77-108. Japanese. PubMed PMID: 11400319.

[5] Hara K, Muraoka Y, Yoshida T, Muranaka R, Kanamori S, Hirashiba M, Uchida H, Ikeuchi K, Kawai M, Hishikawa A, Kaneto M, Kishi K. [Reproductive and developmental toxicity studies of S-1090, cefmatilen hydrochloride hydrate (1)--A study on oral administration prior to and in the early stages of pregnancy in rats]. J Toxicol Sci. 2001 May;26 Suppl [5]157-70. Japanese. PubMed PMID: 11400311.

6: Nishino I, Fujitomo H, Umeda T. Determination of a new oral cephalosporin, cefmatilen hydrochloride hydrate, and its seven metabolites in human and animal plasma and urine by coupled systems of ion-exchange and reversed-phase high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 2000 Nov 10;749(1):101-10. PubMed PMID: 11129069.7: Kondo K, Takase S, Nishimoto Y, Miyajima H, Shiratori O, Miyake Y. [Genotoxicity studies of cefmatilen hydrochloride hydrate (S-1090)]. J Toxicol Sci. 2001 May;26 Suppl 1:243-54. Japanese. PubMed PMID: 11400316.8: Kato I, Nishimura K, Ueno M, Inoue S, Harihara A, Yabuuchi K, Sato K, Miyauchi H, Hirata M, Kimura Y, Furukawa H. [Toxicity study of cefmatilen hydrochloride hydrate (S-1090) (2)--Single oral dose toxicity study in dogs]. J Toxicol Sci. 2001 May;26 Suppl 1:5-12. Japanese. PubMed PMID: 11400318.9: Sameshima H, Ueda T, Haruyama E, Chihaya Y, Mizushima Y, Ueno M, Moriyama T, Kii Y, Kato I. [Toxicity study of cefmatilen hydrochloride hydrate (S-1090) (6)--Six-month repeated oral dose toxicity study in dogs]. J Toxicol Sci. 2001 May;26 Suppl 1:109-34. Japanese. PubMed PMID: 11400307.10: Yahara I, Yamagata H, Ueno M, Inoue S, Sato K, Nishimura K, Miyauchi H, Hirata M, Muraoka Y, Kimura Y, Kitamura T, Kato I. [Toxicity study of cefmatilen hydrochloride hydrate (S-1090) (4)--One- and three-month repeated oral dose toxicity studies in dogs]. J Toxicol Sci. 2001 May;26 Suppl 1:43-76. Japanese. PubMed PMID: 11400317.1

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