724438-16-8|Cefetamet Hydrochloride|(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride|-范德生物科技公司

Cefetamet Hydrochloride

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names：
(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
CAS号：
724438-16-8
MDL Number：
MF(分子式)： C14H16ClN5O5S2 MW(分子量)： 433.882
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Cefetamet Hydrochloride
英文别名	Cefetamet Hydrochloride; Cefetamet HCl; Cefetamet
CAS号	724438-16-8
Inchi	InChI=1S/C14H15N5O5S2.ClH/c1-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24-2)6-4-26-14(15)16-6;/h4,8,12H,3H2,1-2H3,(H2,15,16)(H,17,20)(H,22,23);1H/b18-7-;/t8-,12-;/m1./s1
InchiKey	KILIJEXWGYQTDT-KYIYMPJCSA-N
分子式 Formula	C14H16ClN5O5S2
分子量 Molecular Weight	433.882
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Cefetamet Hydrochloride(CAS:724438-16-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Cefetamet Hydrochloride is a cephalosporin antibiotic potentially for the treatment of bacterial infections. Cefetamet is a potent antibiotic to treat respiratory and urinary tract infections. To improve oral bioavailability, it is administered as a prodrug, cefetamet pivoxyl hydrolyzed by esterase following absorption.
Application1
Application2
Application3

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危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Garbacki P, Cielecka-Piontek J, Zalewski P, Oszczapowicz I, Jelińska A. A SIMPLE AND-SENSITIVE STABILITY-INDICATING UHPLC-DAD METHOD FOR THE DETERMINATION OF CEFETAMET PIVOXIL HYDROCHLORIDE. Acta Pol Pharm. 2016 May-Jun;73(3):621-6. PubMed PMID: 27476279.

[2]Wang D, Wang F, Wang J. Characterization of the impurities and isomers in cefetamet pivoxil hydrochloride by liquid chromatography/time-of-flight mass spectrometry and ion trap mass spectrometry. J Pharm Biomed Anal. 2015;111:71-7. doi: 10.1016/j.jpba.2015.03.013. PubMed PMID: 25863019.

[3] Vadia NH, Patel V, Bhalara HN. Spectrophotometric Determination of Cefetamet Pivoxil Hydrochloride and Pitavastatin Calcium in Tablet Dosage form. Indian J Pharm Sci. 2008 Sep;70(5):649-51. doi: 10.4103/0250-474X.45408. PubMed PMID: 21394266; PubMed Central PMCID: PMC3038294.

[4] Sateesha S, Rajamma A, Shekar H, Divakar G. Formulation development and rheological studies of palatable cefetamet pivoxil hydrochloride dry powder suspension. Daru. 2011;19(2):118-25. PubMed PMID: 22615648; PubMed Central PMCID: PMC3232094.

[5] Jelińska A, Dobrowolski L, Oszczapowicz I. The influence of pH, temperature and buffers on the degradation kinetics of cefetamet pivoxil hydrochloride in aqueous solutions. J Pharm Biomed Anal. 2004 Sep 3;35(5):1273-7. PubMed PMID: 15336372.

6: Jelińska A, Zajac M, Dobrowolski L, Medenecka B, Ruciński P, Oszczapowicz I. Kinetics of degradation of cefetamet pivaloyloxymethyl ester and its hydrochloride in solid phase. Acta Pol Pharm. 2003 Nov-Dec;60(6):435-41. PubMed PMID: 15080590.7: Morsch LM, Bittencourt CF, e Souza MJ, Milano J. LC method for the analysis of cefetamet pivoxil hydrochloride in drug substance and powder for oral suspension. J Pharm Biomed Anal. 2002 Oct 15;30(3):643-49. PubMed PMID: 12367689.8: Du J, Li H. Sensitive chemiluminescence determination of thirteen cephalosporin antibiotics with luminol-copper(II) reaction. Appl Spectrosc. 2010 Oct;64(10):1154-9. doi: 10.1366/000370210792973613. PubMed PMID: 20925986.9: Cazzola M. Novel oral cephalosporins. Expert Opin Investig Drugs. 2000 Feb;9(2):237-46. Review. PubMed PMID: 11060674.10: Noh K, Kim E, Kang W. Quantitative determination of cefetamet in human plasma by liquid chromatography-mass spectrometry. Biomed Chromatogr. 2011 Jul;25(7):779-82. doi: 10.1002/bmc.1516. PubMed PMID: 20845371.

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