908380-97-2|CBS-3595|N-{4-[5-(4-Fluoro-phenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide|-范德生物科技公司

CBS-3595

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names：
N-{4-[5-(4-Fluoro-phenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide
CAS号：
908380-97-2
MDL Number：
MF(分子式)： C18H17FN4O2S MW(分子量)： 372.4184
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	CBS-3595
英文别名	CBS-3595; CBS 3595; CBS3595.
CAS号	908380-97-2
Inchi	InChI=1S/C18H17FN4O2S/c1-11(24)21-15-10-13(8-9-20-15)17-16(12-4-6-14(19)7-5-12)22-18(23(17)2)26(3)25/h4-10H,1-3H3,(H,20,21,24)
InchiKey	DRMJRHUMYBYDIX-UHFFFAOYSA-N
分子式 Formula	C18H17FN4O2S
分子量 Molecular Weight	372.4184
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	CBS-3595(CAS:908380-97-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	CBS-3595 is a potent and Dual p38α MAPK/PDE-4 Inhibitor with Activity against TNFα -related Diseases. CBS-3595 displayed a superior profile regarding its anti-inflammatory effects. CBS-3595 features moderate inhibition of p38α MAPK and PDE-4 in the higher nanomolar range in combination with excellent kinetic properties and low plasma protein binding contributing to the outstanding results of the efficacy experiments performed in animal models and humans. The inhibition of TNFα release was achieved at dose levels and systemic concentrations that were well below levels related to toxicity. CBS-3595 is considered as a candidate drug for the treatment of diseases related to an overproduction of TNFα.
Application1
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危险性	Warning
危险性警示
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备注

[1]Albrecht W, Unger A, Bauer SM, Laufer SA. Discovery ofN-{4-[5-(4-Fluoro-phenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with Activity againstTNFα -related Diseases. J Med Chem. 2017 Jun 14. doi:10.1021/acs.jmedchem.6b01647. [Epub ahead of print] PubMed PMID: 28613871.

[2]Koch DA, Silva RB, de Souza AH, Leite CE, Nicoletti NF, Campos MM, Laufer S,Morrone FB. Efficacy and gastrointestinal tolerability of ML3403, a selectiveinhibitor of p38 MAP kinase and CBS-3595, a dual inhibitor of p38 MAP kinase andphosphodiesterase 4 in CFA-induced arthritis in rats. Rheumatology (Oxford). 2014Mar;53(3):425-32. doi: 10.1093/rheumatology/ket369. Epub 2013 Nov 15. PubMedPMID: 24241037.

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