76849-19-9|CB 3717|(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)(prop-2-yn-1-yl)amino)benzoyl)-L-glutamic acid|-范德生物科技公司

CB 3717

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names：
(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)(prop-2-yn-1-yl)amino)benzoyl)-L-glutamic acid
CAS号：
76849-19-9
MDL Number：
MF(分子式)： C24H23N5O6 MW(分子量)： 477.47
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	CB 3717
英文别名	CB 3717; CB-3717; CB3717; N(sup 10)-Propargyl-5,8-dideazafolic acid;
CAS号	76849-19-9
Inchi	InChI=1S/C24H23N5O6/c1-2-11-29(13-14-3-8-18-17(12-14)22(33)28-24(25)27-18)16-6-4-15(5-7-16)21(32)26-19(23(34)35)9-10-20(30)31/h1,3-8,12,19H,9-11,13H2,(H,26,32)(H,30,31)(H,34,35)(H3,25,27,28,33)/t19-/m0/s1
InchiKey	LTKHPMDRMUCUEB-IBGZPJMESA-N
分子式 Formula	C24H23N5O6
分子量 Molecular Weight	477.47
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	CB 3717(CAS:76849-19-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	CB 3717 is an antineoplastic agent; folic acid antagonist; enzyme inhibitor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Bayoumi AS, Teoh JP, Aonuma T, Yuan Z, Ruan X, Tang Y, Su H, Weintraub NL, Kim IM. MicroRNA-532 protects the heart in acute myocardial infarction, and represses prss23, a positive regulator of endothelial-to-mesenchymal transition. Cardiovasc Res. 2017 Nov 1;113(13):1603-1614. doi: 10.1093/cvr/cvx132. PubMed PMID: 29016706; PubMed Central PMCID: PMC5852516.

[2]Tang Y, Wang Y, Park KM, Hu Q, Teoh JP, Broskova Z, Ranganathan P, Jayakumar C, Li J, Su H, Tang Y, Ramesh G, Kim IM. MicroRNA-150 protects the mouse heart from ischaemic injury by regulating cell death. Cardiovasc Res. 2015 Jun 1;106(3):387-97. doi: 10.1093/cvr/cvv121. Epub 2015 Mar 30. PubMed PMID: 25824147; PubMed Central PMCID: PMC4447807.

[3] Müller C, Reddy JA, Leamon CP, Schibli R. Effects of the antifolates pemetrexed and CB3717 on the tissue distribution of (99m)Tc-EC20 in xenografted and syngeneic tumor-bearing mice. Mol Pharm. 2010 Apr 5;7(2):597-604. doi: 10.1021/mp900296k. PubMed PMID: 20199053.

[4] Arvizu-Flores AA, Aispuro-Hernandez E, Garcia-Orozco KD, Varela-Romero A, Valenzuela-Soto E, Velazquez-Contreras EF, Rojo-Domínguez A, Yepiz-Plascencia G, Maley F, Sotelo-Mundo RR. Functional identity of the active sites of crustacean and viral thymidylate synthases. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Sep;150(3):406-13. doi: 10.1016/j.cbpc.2009.06.008. Epub 2009 Jun 25. PubMed PMID: 19559812.

[5] Dudkowska M, Bajer S, Jaworski T, Zielińska J, Manteuffel-Cymborowska M, Grzelakowska-Sztabert B. Antifolate/folate-activated HGF/c-Met signalling pathways in mouse kidneys-the putative role of their downstream effectors in cross-talk with androgen receptor. Arch Biochem Biophys. 2009 Mar 1;483(1):111-9. doi: 10.1016/j.abb.2008.12.015. Epub 2008 Dec 30. PubMed PMID: 19135973.

6: Doan LT, Martucci WE, Vargo MA, Atreya CE, Anderson KS. Nonconserved residues Ala287 and Ser290 of the Cryptosporidium hominis thymidylate synthase domain facilitate its rapid rate of catalysis. Biochemistry. 2007 Jul 17;46(28):8379-91. Epub 2007 Jun 20. PubMed PMID: 17580969.7: Dudkowska M, Jaworski T, Grzelakowska-Sztabert B, Manteuffel-Cymborowska M. Androgen receptor and c-Myc transcription factors as putative partners in the in vivo cross-talk between androgen receptor-mediated and c-Met-mediated signalling pathways. Acta Biochim Pol. 2007;54(2):253-9. Epub 2007 May 23. PubMed PMID: 17520086.8: Grzelakowska-Sztabert B, Dudkowska M, Manteuffel-Cymborowska M. Nuclear and membrane receptor-mediated signalling pathways modulate polyamine biosynthesis and interconversion. Biochem Soc Trans. 2007 Apr;35(Pt 2):386-90. PubMed PMID: 17371283.9: Stachurska A, Dudkowska M, Czopek A, Manteuffel-Cymborowska M, Grzelakowska-Sztabert B. Cisplatin up-regulates the in vivo biosynthesis and degradation of renal polyamines and c-Myc expression. Biochim Biophys Acta. 2004 Aug 4;1689(3):259-66. PubMed PMID: 15276653.10: Theti DS, Bavetsias V, Skelton LA, Titley J, Gibbs D, Jansen G, Jackman AL. Selective delivery of CB300638, a cyclopenta[g]quinazoline-based thymidylate synthase inhibitor into human tumor cell lines overexpressing the alpha-isoform of the folate receptor. Cancer Res. 2003 Jul 1;63(13):3612-8. PubMed PMID: 12839949.1

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