468-76-8|Cassaine|Acetic acid, (dodecahydro-7-hydroxy-1,4b,8,8-tetramethyl-10-oxo-2(1H)-phenanthrenylidene)-, 2-(dimethylamino)ethyl ester, (1R-(1alpha,2E,4aalpha,4bbeta,7beta,8aalpha,10abeta))-|-范德生物科技公司

Cassaine

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names：
Acetic acid, (dodecahydro-7-hydroxy-1,4b,8,8-tetramethyl-10-oxo-2(1H)-phenanthrenylidene)-, 2-(dimethylamino)ethyl ester, (1R-(1alpha,2E,4aalpha,4bbeta,7beta,8aalpha,10abeta))-
CAS号：
468-76-8
MDL Number：
MF(分子式)： C24H39NO4 MW(分子量)： 405.579
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Cassaine
英文别名	Cassaine; Nervocidine
CAS号	468-76-8
Inchi	InChI=1S/C24H39NO4/c1-15-16(13-21(28)29-12-11-25(5)6)7-8-17-22(15)18(26)14-19-23(2,3)20(27)9-10-24(17,19)4/h13,15,17,19-20,22,27H,7-12,14H2,1-6H3/b16-13+/t15-,17-,19-,20-,22-,24+/m0/s1
InchiKey	GMHWATCMBXIANN-IOJUAHGHSA-N
分子式 Formula	C24H39NO4
分子量 Molecular Weight	405.579
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Cassaine(CAS:468-76-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Cassaine is an erythrophleum alkaloid.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Ha MT, Tran MH, Phuong TT, Kim JA, Woo MH, Choi JS, Lee S, Lee JH, Lee HK, Min BS. Cytotoxic and apoptosis-inducing activities against human lung cancer cell lines of cassaine diterpenoids from the bark of Erythrophleum fordii. Bioorg Med Chem Lett. 2017 Jul 1;27(13):2946-2952. doi: 10.1016/j.bmcl.2017.05.006. Epub 2017 May 4. PubMed PMID: 28506750.

[2]Hung TM, Cuong TD, Kim JA, Tae N, Lee JH, Min BS. Cassaine diterpene alkaloids from Erythrophleum fordii and their anti-angiogenic effect. Bioorg Med Chem Lett. 2014 Jan 1;24(1):168-72. doi: 10.1016/j.bmcl.2013.11.048. Epub 2013 Nov 27. PubMed PMID: 24332631.

[3] Ravindar K, Caron PY, Deslongchamps P. Anionic polycyclization entry to tricycles related to quassinoids and terpenoids: a stereocontrolled total synthesis of (+)-cassaine. J Org Chem. 2014 Sep 5;79(17):7979-99. doi: 10.1021/jo501122k. Epub 2014 Aug 7. PubMed PMID: 25057897.

[4] Hung TM, Cuong TD, Kim JA, Lee JH, Woo MH, Min BS. In vitro apoptotic effect of cassaine-type diterpene amides from Erythrophleum fordii on PC-3 prostate cancer cells. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4989-94. doi: 10.1016/j.bmcl.2014.09.025. Epub 2014 Sep 16. PubMed PMID: 25278231.

[5] Du D, Qu J, Wang JM, Yu SS, Chen XG, Xu S, Ma SG, Li Y, Ding GZ, Fang L. Cytotoxic cassaine diterpenoid-diterpenoid amide dimers and diterpenoid amides from the leaves of Erythrophleum fordii. Phytochemistry. 2010 Oct;71(14-15):1749-55. doi: 10.1016/j.phytochem.2010.07.004. Epub 2010 Aug 2. PubMed PMID: 20678783.

6: Tae N, Hung TM, Kim O, Kim N, Lee S, Na S, Min BS, Lee JH. A cassaine diterpene alkaloid, 3β-acetyl-nor-erythrophlamide, suppresses VEGF-induced angiogenesis and tumor growth via inhibiting eNOS activation. Oncotarget. 2017 Sep 28;8(54):92346-92358. doi: 10.18632/oncotarget.21307. eCollection 2017 Nov 3. PubMed PMID: 29190920; PubMed Central PMCID: PMC5696186.7: COTTEN MD, GOLDBERG LI, WALTON RP. Cassaine and cassaidine: quantitative measurements of heart contractile force in situ. J Pharmacol Exp Ther. 1952 Sep;106(1):94-102. PubMed PMID: 14955792.8: Ravindar K, Caron PY, Deslongchamps P. Total synthesis of (+)-cassaine utilizing an anionic polycyclization strategy. Org Lett. 2013 Dec 20;15(24):6270-3. doi: 10.1021/ol4030937. Epub 2013 Dec 2. PubMed PMID: 24295200.9: Ngo TC, Nguyen TH, Dao DQ. Radical Scavenging Activity of Natural-Based Cassaine Diterpenoid Amides and Amines. J Chem Inf Model. 2019 Feb 25;59(2):766-776. doi: 10.1021/acs.jcim.8b00847. Epub 2019 Feb 6. PubMed PMID: 30681326.10: Armah FA, Amponsah IK, Mensah AY, Dickson RA, Steenkamp PA, Madala NE, Adokoh CK. Leishmanicidal activity of the root bark of Erythrophleum Ivorense (Fabaceae) and identification of some of its compounds by ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-QTOF-MS/MS). J Ethnopharmacol. 2018 Jan 30;211:207-216. doi: 10.1016/j.jep.2017.09.030. Epub 2017 Sep 29. PubMed PMID: 28970156.1

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