123123-32-0|Bullatacin|(S)-3-((2R,13R)-2,13-dihydroxy-13-((2R,2'R,5S,5'R)-5'-((S)-1-hydroxyundecyl)octahydro-[2,2'-bifuran]-5-yl)tridecyl)-5-methylfuran-2(5H)-one|-范德生物科技公司

Bullatacin

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names：
(S)-3-((2R,13R)-2,13-dihydroxy-13-((2R,2'R,5S,5'R)-5'-((S)-1-hydroxyundecyl)octahydro-[2,2'-bifuran]-5-yl)tridecyl)-5-methylfuran-2(5H)-one
CAS号：
123123-32-0
MDL Number：
MF(分子式)： C37H66O7 MW(分子量)： 622.92
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Bullatacin
英文别名	Bullatacin; LI 12105; LI-12105; LI12105 Rolliniastatin 2; Squamocin G; Annonareticin; ( )-Bullatacin;
CAS号	123123-32-0
Inchi	InChI=1S/C37H66O7/c1-3-4-5-6-7-11-14-17-20-31(39)33-22-24-35(43-33)36-25-23-34(44-36)32(40)21-18-15-12-9-8-10-13-16-19-30(38)27-29-26-28(2)42-37(29)41/h26,28,30-36,38-40H,3-25,27H2,1-2H3/t28-,30+,31-,32+,33+,34-,35+,36+/m0/s1
InchiKey	MBABCNBNDNGODA-BAVRERFOSA-N
分子式 Formula	C37H66O7
分子量 Molecular Weight	622.92
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Bullatacin(CAS:123123-32-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Bullatacin is a bis(tetrahydrofuranoid) fatty acid lactone found in some fruits from Annonaceae family. It is a member of the class of compounds known as acetogenins.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Chen Y, Chen JW, Liu SJ, Xu CL, Xu HQ, Cai BC, Li X, Ju WZ. Determination of bullatacin in rat plasma by liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 May 15;897:94-7. doi: 10.1016/j.jchromb.2012.03.044. Epub 2012 Apr 1[1]PubMed PMID: 22534655.

[2]Shi JF, Wu P, Jiang ZH, Wei XY. Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins. Eur J Med Chem. 2014 Jan;71:219-28. doi: 10.1016/j.ejmech.2013.11.012. Epub 2013 Nov 15. PubMed PMID: 24308999.

[3] Chih HW, Chiu HF, Tang KS, Chang FR, Wu YC. Bullatacin, a potent antitumor annonaceous acetogenin, inhibits proliferation of human hepatocarcinoma cell line 2.2.15 by apoptosis induction. Life Sci. 2001 Aug 3;69(11):1321-31. PubMed PMID: 11521756.

[4] Morré DJ, de Cabo R, Farley C, Oberlies NH, McLaughlin JL. Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes. Life Sci. 1995;56(5):343-8. PubMed PMID: 7837933.

[5] Liang YJ, Zhang X, Dai CL, Zhang JY, Yan YY, Zeng MS, Chen LM, Fu LW. Bullatacin triggered ABCB1-overexpressing cell apoptosis via the mitochondrial-dependent pathway. J Biomed Biotechnol. 2009;2009:867123. doi: 10.1155/2009/867123. Epub 2009 Jul 21. PubMed PMID: 19639048; PubMed Central PMCID: PMC2715821.

6: Hui YH, Rupprecht JK, Liu YM, Anderson JE, Smith DL, Chang CJ, McLaughlin JL. Bullatacin and bullatacinone: two highly potent bioactive acetogenins from Annona bullata. J Nat Prod. 1989 May-Jun;52(3):463-77. PubMed PMID: 2778448.7: Chiu HF, Chih TT, Hsian YM, Tseng CH, Wu MJ, Wu YC. Bullatacin, a potent antitumor Annonaceous acetogenin, induces apoptosis through a reduction of intracellular cAMP and cGMP levels in human hepatoma 2.2.15 cells. Biochem Pharmacol. 2003 Feb 1;65(3):319-27. PubMed PMID: 12527325.8: Mangal M, Khan MI, Agarwal SM. Acetogenins as Potential Anticancer Agents. Anticancer Agents Med Chem. 2015;16(2):138-59. Review. PubMed PMID: 26118710.9: Oberlies NH, Croy VL, Harrison ML, McLaughlin JL. The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells. Cancer Lett. 1997 May 1;115(1):73-9. PubMed PMID: 9097981.10: Chen Y, Chen JW, Zhai JH, Wang Y, Wang SL, Li X. Antitumor activity and toxicity relationship of annonaceous acetogenins. Food Chem Toxicol. 2013 Aug;58:394-400. doi: 10.1016/j.fct.2013.05.028. Epub 2013 May 24. PubMed PMID: 23712095.1

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