72293-40-4|Btm 1042|1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-((4-methyl-1-piperazinyl)methyl)-2-phenyl-, dihydrochloride, cis-(-)-|-范德生物科技公司

Btm 1042

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names：
1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-((4-methyl-1-piperazinyl)methyl)-2-phenyl-, dihydrochloride, cis-(-)-
CAS号：
72293-40-4
MDL Number：
MF(分子式)： C21H27Cl2N3OS MW(分子量)： 440.427
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Btm 1042
英文别名	Btm 1042; Btm1042; Btm-1042
CAS号	72293-40-4
Inchi	InChI=1S/C21H25N3OS.2ClH/c1-23-11-13-24(14-12-23)15-17-20(16-7-3-2-4-8-16)26-19-10-6-5-9-18(19)22-21(17)25;;/h2-10,17,20H,11-15H2,1H3,(H,22,25);2*1H/t17-,20+;;/m0../s1
InchiKey	YRHGKQWXSOSAQX-RHXOVYDGSA-N
分子式 Formula	C21H27Cl2N3OS
分子量 Molecular Weight	440.427
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Btm 1042(CAS:72293-40-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Btm 1042 is an antispasmodic drug that has been found to depress twitch responses in the ileum of guinea pig.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Noronha-Blob L, Sturm BL, Lowe VC, Jackson KN, Kachur JF. In vitro and in vivo antimuscarinic effects of (-)cis 2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5 benzothiazepin-4-(5H)one HCl (BTM-1086) in guinea pig peripheral tissues. Life Sci. 1990;46(17):1223-3[1]PubMed PMID: 2338887.

[2]Takayanagi I, Nakazo K, Kizawa Y. Possible mechanisms of a new type of antispasmodic drug, BTM-1042(cis-(--)-2,3-dihydro-3-(4-methyl-piperazinyl)methyl-2-phenyl-1,5-benzoth iazepin-4(5H)-one dihydrochloride). Jpn J Pharmacol. 1980 Oct;30(5):647-54. PubMed PMID: 7206371.

[3] Yamamoto H, Nakamura Y, Nagasaka M, Asai H. Specificity in the pharmacological actions of optical isomers of cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5- benzothiazepin-4(5H)-one (BTM). Chem Pharm Bull (Tokyo). 1987 Aug;35(8):3419-24. PubMed PMID: 3427721.

[4] Asano T, Okumura T, Hirano K, Adachi T, Sugiura M. Competitive enzyme immunoassay for anti-ulcer agent, (-)-cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5- benzothiazepin-4(5H)-one hydrochloride (BTM-1086). Chem Pharm Bull (Tokyo). 1986 Oct;34(10):4238-43. PubMed PMID: 3549012.

[5] Ohno S, Izumi K, Mizukoshi K, Kato K, Hori M. Synthesis of a new potent anti-ulcer and gastric secretory inhibiting agent, (-)-cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5-benzothiazepin-4(5 H)-one hydrochloride (BTM-1086), and related compounds. Chem Pharm Bull (Tokyo). 1983 May;31(5):1780-3. PubMed PMID: 6616728.

6: Yamamoto H, Asai H. Effects of (-)-cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl- 1,5-benzothiaze pin-4-(5H)-one hydrochloride (BTM-1086) on ulceration, gastric secretion and mucosal blood flow in experimental animals. Chem Pharm Bull (Tokyo). 1986 Sep;34(9):3844-53. PubMed PMID: 3815606.7: Eltze M, Boer R, Mutschler E, Lambrecht G. Affinity profiles of BTM-1086 and BTM-1041 at muscarinic receptor subtypes and at H1- and alpha 1-receptors. Eur J Pharmacol. 1989 Nov 7;170(3):225-34. PubMed PMID: 2575995.8: Yamamoto H, Nakamura Y, Kunoh Y, Ichihara K, Nagasaka M, Asai H. Antiulcer effect of (-)-cis-2,3-dihydro-3-(4-methylpiperazinylmethyl) -2-phenyl-1,5-benzothiazepin-4-(5H)-one hydrochloride (BTM-1086) in experimental animals. Jpn J Pharmacol. 1986 Jul;41(3):283-92. PubMed PMID: 3761747.9: Takayanagi I, Konno F, Akaike M, Nibori Y, Yamura S. cis(-)-2,3-Dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5- benzothiazepin-4(5H)-one monohydrochloride and its butylbromide as M1-receptor antagonists. Gen Pharmacol. 1987;18(1):91-3. PubMed PMID: 3557056.10: Murakami H, Ishikawa T, Watanabe H. Acetylcholine release elicited by electrical stimulation and its sites of action in smooth muscle of Mytilus. Comp Biochem Physiol C. 1984;77(2):273-7. PubMed PMID: 6144427.1

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