127245-22-1|Biofor 389|2H-1,2-Oxazin-3(4H)-one, 4-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)dihydro-2-methyl-|-范德生物科技公司

Biofor 389

NMR下载 COA and HPLC MSDS下载
names：
2H-1,2-Oxazin-3(4H)-one, 4-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)dihydro-2-methyl-
CAS号：
127245-22-1
MDL Number：
MF(分子式)： C20H29NO3 MW(分子量)： 331.456
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Biofor 389
英文别名	BF 389
CAS号	127245-22-1
SMILES	O=C1N(C)OCC/C1=C\C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2
Inchi	InChI=1S/C20H29NO3/c1-19(2,3)15-11-13(12-16(17(15)22)20(4,5)6)10-14-8-9-24-21(7)18(14)23/h10-12,22H,8-9H2,1-7H3/b14-10+
InchiKey	BWRYNNCGEDOTRW-GXDHUFHOSA-N
分子式 Formula	C20H29NO3
分子量 Molecular Weight	331.456
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Biofor 389(CAS:127245-22-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Biofor 389 is a potent, orally active, antiarthritic and analgesic agent with low ulcerogenic potential.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Veerhuis R, Hoozemans JJ, Janssen I, Boshuizen RS, Langeveld JP, Eikelenboom P. Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E2. Brain Res. 2002 Jan 25;925(2):195-203. PubMed PMID: 11792368.

[2]Blom MA, van Twillert MG, de Vries SC, Engels F, Finch CE, Veerhuis R, Eikelenboom P. NSAIDS inhibit the IL-1 beta-induced IL-6 release from human post-mortem astrocytes: the involvement of prostaglandin E2. Brain Res. 1997 Nov 28;777(1-2):210-8. PubMed PMID: 9449430.

[3] Wong S, Lee SJ, Frierson MR 3rd, Proch J, Miskowski TA, Rigby BS, Schmolka SJ, Naismith RW, Kreutzer DC, Lindquist R. Antiarthritic profile of BF-389--a novel anti-inflammatory agent with low ulcerogenic liability. Agents Actions. 1992 Sep;37(1-2):90-8. PubMed PMID: 1456184.

[4] Bendele AM, Ruterbories KJ, Spaethe SM, Benslay DN, Lindstrom TD, Lee SJ, Naismith RW. Correlation of anti-inflammatory activity with peak tissue rather than peak plasma levels of BF389. J Pharmacol Exp Ther. 1992 Mar;260(3):1194-8. PubMed PMID: 1545387.

[5] Bendele AM, Benslay DN, Hom JT, Spaethe SM, Ruterbories KJ, Lindstrom TD, Lee SJ, Naismith RW. Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis. J Pharmacol Exp Ther. 1992 Jan;260(1):300-5. PubMed PMID: 1309875.

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