103810-45-3|Bidisomide|2-(2-chlorophenyl)-4-(N-isopropylacetamido)-2-(2-(piperidin-1-yl)ethyl)butanamide|-范德生物科技公司

Bidisomide

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names：
2-(2-chlorophenyl)-4-(N-isopropylacetamido)-2-(2-(piperidin-1-yl)ethyl)butanamide
CAS号：
103810-45-3
MDL Number：
MF(分子式)： C22H34ClN3O2 MW(分子量)： 407.98
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Bidisomide
英文别名	Bidisomide; Pulmicort; SC 40230; SC-40230; SC40230;
CAS号	103810-45-3
Inchi	InChI=1S/C22H34ClN3O2/c1-17(2)26(18(3)27)16-12-22(21(24)28,19-9-5-6-10-20(19)23)11-15-25-13-7-4-8-14-25/h5-6,9-10,17H,4,7-8,11-16H2,1-3H3,(H2,24,28)
InchiKey	GTEPPJFJSNSNIH-UHFFFAOYSA-N
分子式 Formula	C22H34ClN3O2
分子量 Molecular Weight	407.98
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Bidisomide(CAS:103810-45-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Bidisomide is a medication of the corticosteroid type with antiarrhythmic effects.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Treatment of atrial fibrillation and paroxysmal supraventricular tachycardia with bidisomide. The Atrial Fibrillation Investigation with Bidisomide (AFIB) Investigators. Circulation. 1997 Oct 21;96(8):2625-32. PubMed PMID: 9355903.

[2]Pao LH, Zhou SY, Cook C, Kararli T, Kirchhoff C, Truelove J, Karim A, Fleisher D. Reduced systemic availability of an antiarrhythmic drug, bidisomide, with meal co-administration: relationship with region-dependent intestinal absorption. Pharm Res. 1998 Feb;15(2):221-7. PubMed PMID: 9523307.

[3] Martin CL, Palomo MA, Mcmahon EG. Comparison of bidisomide, flecainide and dofetilide on action potential duration in isolated canine atria: effect of isoproterenol. J Pharmacol Exp Ther. 1996 Jul;278(1):154-62. PubMed PMID: 8764346.

[4] Cook CS, Ames GB, Smith ME, Kowalski KG, Karim A. Absorption and disposition of a new antiarrhythmic agent bidisomide in man. Pharm Res. 1993 Nov;10(11):1675-82. PubMed PMID: 8290484.

[5] Komori S, Sano S, Li BH, Matsumura K, Naitoh A, Mochizuki S, Ishihara T, Watanabe A, Umetani K, Ijiri H, et al. Effects of bidisomide (SC-40230), a new class I antiarrhythmic agent, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats; comparison with mexiletine and disopyramide. Heart Vessels. 1995;10(1):7-11. PubMed PMID: 7537263.

6: Homma N, Tsujimoto G, Hashimoto K. Electrophysiologic effects of an antiarrhythmic agent, bidisomide, on sodium current in isolated rat ventricular myocytes: comparison with mexiletine and disopyramide. Jpn J Pharmacol. 2001 May;86(1):23-31. PubMed PMID: 11430469.7: Cook CS, Lonien M, Hribar J. Effect of diet and gavage on the dose- and dose-mode-dependent absorption and metabolism of bidisomide in rat. Xenobiotica. 2000 May;30(5):523-33. PubMed PMID: 10875685.8: Lee KH, Xu GX, Schoenhard GL, Cook CS. Mechanisms of food effects of structurally related antiarrhythmic drugs, disopyramide and bidisomide in the rat. Pharm Res. 1997 Aug;14(8):1030-8. PubMed PMID: 9279885.9: Cook CS, McDonald SJ, Karim A. Importance of pharmacokinetic and physicochemical data in the discovery and development of novel anti-arrhythmic drugs. Xenobiotica. 1993 Nov;23(11):1299-309. PubMed PMID: 8310713.10: Vandenberghe Y, Masson M, Palate B, Roba J. Effect of folate supplementation on clinical chemistry and hematologic changes related to bidisomide administration in the rat. Drug Chem Toxicol. 1995 Nov;18(4):235-70. PubMed PMID: 8586020.1

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