143484-82-6|Azalanstat dihydrochloride|Benzenamine, 4-(((2-(2-(4-chlorophenyl)ethyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methyl)thio)-, dihydrochloride, (2S-cis)-|-范德生物科技公司

Azalanstat dihydrochloride

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names：
Benzenamine, 4-(((2-(2-(4-chlorophenyl)ethyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methyl)thio)-, dihydrochloride, (2S-cis)-
CAS号：
143484-82-6
MDL Number：
MF(分子式)： C22H26Cl3N3O2S MW(分子量)： 502.88
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Azalanstat dihydrochloride
英文别名	Azalanstat dihydrochloride, Azalanstat HCl, RS-21607-197
CAS号	143484-82-6
Inchi	1S/C22H24ClN3O2S.2ClH/c23-18-3-1-17(2-4-18)9-10-22(15-26-12-11-25-16-26)27-13-20(28-22)14-29-21-7-5-19(24)6-8-21;;/h1-8,11-12,16,20H,9-10,13-15,24H2;2*1H/t20-,22-;;/m0../s1
InchiKey	UTHWWPSFKXCLMU-HWELVIDPSA-N
分子式 Formula	C22H26Cl3N3O2S
分子量 Molecular Weight	502.88
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Azalanstat dihydrochloride(CAS:143484-82-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Azalanstat dihydrochloride is an inhibitor of the enzyme lanosterol 14 alpha-demethylase which catalyzes the first step in conversion of lanosterol to cholesterol in mammals.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Burton PM, Swinney DC, Heller R, Dunlap B, Chiou M, Malonzo E, Haller J, Walker KA, Salari A, Murakami S, et al. Azalanstat (RS-21607), a lanosterol 14 alpha-demethylase inhibitor with cholesterol-lowering activity. Biochem Pharmacol. 1995 Aug 8;50(4):529-44. PubMed PMID: 7646560.

[2]Vlahakis JZ, Kinobe RT, Bowers RJ, Brien JF, Nakatsu K, Szarek WA. Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1457-61. PubMed PMID: 15713406.

[3] Morisawa T, Wong RJ, Bhutani VK, Vreman HJ, Stevenson DK. Inhibition of heme oxygenase activity in newborn mice by azalanstat. Can J Physiol Pharmacol. 2008 Oct;86(10):651-9. doi: 10.1139/y08-069. PubMed PMID: 18841169.

[4] Pittalà V, Salerno L, Romeo G, Modica MN, Siracusa MA. A focus on heme oxygenase-1 (HO-1) inhibitors. Curr Med Chem. 2013;20(30):3711-32. Review. PubMed PMID: 23746277.

[5] Rahman MN, Vlahakis JZ, Roman G, Vukomanovic D, Szarek WA, Nakatsu K, Jia Z. Structural characterization of human heme oxygenase-1 in complex with azole-based inhibitors. J Inorg Biochem. 2010 Mar;104(3):324-30. doi: 10.1016/j.jinorgbio.2009.10.011. Epub 2009 Oct 24. Review. PubMed PMID: 19917515.

6: Vlahakis JZ, Kinobe RT, Bowers RJ, Brien JF, Nakatsu K, Szarek WA. Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors. J Med Chem. 2006 Jul 13;49(14):4437-41. PubMed PMID: 16821802.7: Ahmed H, McLaughlin BE, Soong J, Marks GS, Brien JF, Nakatsu K. The source of endogenous carbon monoxide formation in human placental chorionic villi. Cell Mol Biol (Noisy-le-grand). 2005 Oct 3;51(5):447-51. PubMed PMID: 16309566.8: Vaknin KM, Lazar S, Popliker M, Tsafriri A. Role of meiosis-activating sterols in rat oocyte maturation: effects of specific inhibitors and changes in the expression of lanosterol 14alpha-demethylase during the preovulatory period. Biol Reprod. 2001 Jan;64(1):299-309. PubMed PMID: 11133687.9: Rahman MN, Vukomanovic D, Vlahakis JZ, Szarek WA, Nakatsu K, Jia Z. Structural insights into human heme oxygenase-1 inhibition by potent and selective azole-based compounds. J R Soc Interface. 2013 Jan 6;10(78):20120697. doi: 10.1098/rsif.2012.0697. Epub 2012 Nov 8. PubMed PMID: 23097500; PubMed Central PMCID: PMC3565801.10: Wang C, Xie H, Song X, Ning G, Yan J, Chen X, Xu B, Ouyang H, Xia G. Lanosterol 14alpha-demethylase expression in the mouse ovary and its participation in cumulus-enclosed oocyte spontaneous meiotic maturation in vitro. Theriogenology. 2006 Sep 15;66(5):1156-64. Epub 2006 May 2. PubMed PMID: 16650467.1

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