846056-87-9|Auriclosene|2-(dichloroamino)-2-methylpropane-1-sulfonic acid|-范德生物科技公司

Auriclosene

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names：
2-(dichloroamino)-2-methylpropane-1-sulfonic acid
CAS号：
846056-87-9
MDL Number：
MF(分子式)： C4H9Cl2NO3S MW(分子量)： 222.08
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Auriclosene
英文别名	NVC-422; NVC 422; NVC422; CD07223; CD-07223; CD 07223; Auriclosene.
CAS号	846056-87-9
Inchi	InChI=1S/C4H9Cl2NO3S/c1-4(2,7(5)6)3-11(8,9)10/h3H2,1-2H3,(H,8,9,10)
InchiKey	QYNRGGHZWCUZLK-UHFFFAOYSA-N
分子式 Formula	C4H9Cl2NO3S
分子量 Molecular Weight	222.08
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Auriclosene(CAS:846056-87-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Auriclosene, also known as NVC-422 and CD07223, a potent and Broad spectrum antimicrobial agent. NVC-422 kills in vitro, all bacteria, viruses, yeasts and fungi against which they have been tested. NVC-422 is highly effective in in vitro studies against multi-drug resistant bacteria including Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant Enterococcus (VRE). Auriclosene was demonstrated to be highly effective against well-established biofilm grown on urinary tract catheters. Auriclosene demonstrates greater in vitro therapeutic index (ratio of toxicity to efficacy) than existing topical antiseptics.
Application1
Application2
Application3

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[1]Rani SA, Celeri C, Najafi R, Bley K, Debabov D. Irrigation with N,N-dichloro-2,2-dimethyltaurine (NVC-422) in a citrate buffer maintains urinary catheter patency in vitro and prevents encrustation by Proteus mirabilis. Urolithiasis. 2015 Aug 18. [Epub ahead of print] PubMed PMID: 26282899.

[2]Gupta AK, Simpson FC. Investigational drugs for onychomycosis. Expert Opin Investig Drugs. 2014 Jan;23(1):97-106. doi: 10.1517/13543784.2013.840289. Epub 2013 Sep 26. Review. PubMed PMID: 24070182.

[3] Ghannoum MA, Long L, Cirino AJ, Miller AR, Najafi R, Wang L, Sharma K, Anderson M, Memarzadeh B. Efficacy of NVC-422 in the treatment of dermatophytosis caused by Trichophyton mentagrophytes using a guinea pig model. Int J Dermatol. 2013 May;52(5):567-71. doi: 10.1111/j.1365-4632.2012.05477.x. PubMed PMID: 23590371.

[4] Jekle A, Abdul Rani S, Celeri C, Zuck M, Xu P, Wang L, Najafi-Tagol K, Anderson M, Stroman D, Debabov D. Broad-spectrum virucidal activity of (NVC-422) N,N-dichloro-2,2-dimethyltaurine against viral ocular pathogens in vitro. Invest Ophthalmol Vis Sci. 2013 Feb 19;54(2):1244-51. doi: 10.1167/iovs.12-10700. PubMed PMID: 23341010.

[5] Jekle A, Yoon J, Zuck M, Najafi R, Wang L, Shiau T, Francavilla C, Rani SA, Eitzinger C, Nagl M, Anderson M, Debabov D. NVC-422 inactivates Staphylococcus aureus toxins. Antimicrob Agents Chemother. 2013 Feb;57(2):924-9. doi: 10.1128/AAC.01945-12. Epub 2012 Dec 3. PubMed PMID: 23208720; PubMed Central PMCID: PMC3553688.

6: Eitzinger C, Ehrlenbach S, Lindner H, Kremser L, Gottardi W, Debabov D, Anderson M, Nagl M, Orth D. N-chlorotaurine, a long-lived oxidant produced by human leukocytes, inactivates Shiga toxin of enterohemorrhagic Escherichia coli. PLoS One. 2012;7(11):e47105. doi: 10.1371/journal.pone.0047105. Epub 2012 Nov 6. PubMed PMID: 23139739; PubMed Central PMCID: PMC3491008.7: Teuchner B, Eitzinger C, Lutz M, Hager T, Schmid E, Bechrakis NE, Zuck M, Jekle A, Debabov D, Anderson M, Nagl M. N-chlorotaurine and its analogues N,N-dichloro-2,2-dimethyltaurine and N-monochloro-2,2-dimethyltaurine are safe and effective bactericidal agents in ex vivo corneal infection models. Acta Ophthalmol. 2012 Dec;90(8):e632-7. doi: 10.1111/j.1755-3768.2012.02501.x. Epub 2012 Sep 12. PubMed PMID: 22971221.8: Singhal D, Jekle A, Debabov D, Wang L, Khosrovi B, Anderson M, Foreman A, Wormald PJ. Efficacy of NVC-422 against Staphylococcus aureus biofilms in a sheep biofilm model of sinusitis. Int Forum Allergy Rhinol. 2012 Jul-Aug;2(4):309-15. doi: 10.1002/alr.21038. Epub 2012 Mar 20. PubMed PMID: 22434724.9: D'Lima L, Friedman L, Wang L, Xu P, Anderson M, Debabov D. No decrease in susceptibility to NVC-422 in multiple-passage studies with methicillin-resistant Staphylococcus aureus, S. aureus, Pseudomonas aeruginosa, and Escherichia coli. Antimicrob Agents Chemother. 2012 May;56(5):2753-5. doi: 10.1128/AAC.05985-11. Epub 2012 Feb 21. PubMed PMID: 22354299; PubMed Central PMCID: PMC3346591.10: Martini C, Hammerer-Lercher A, Zuck M, Jekle A, Debabov D, Anderson M, Nagl M. Antimicrobial and anticoagulant activities of N-chlorotaurine, N,N-dichloro-2,2-dimethyltaurine, and N-monochloro-2,2-dimethyltaurine in human blood. Antimicrob Agents Chemother. 2012 Apr;56(4):1979-84. doi: 10.1128/AAC.05685-11. Epub 2012 Jan 17. PubMed PMID: 22252818; PubMed Central PMCID: PMC3318392.1

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