1204178-50-6|ASP3662|4-{5-[2-(4-Chloro-2,6-difluorophenoxy)propan-2-yl]-4-methyl-4H-1,2,4-triazol-3-yl}-3-fluorobenzamide|-范德生物科技公司

ASP3662

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names：
4-{5-[2-(4-Chloro-2,6-difluorophenoxy)propan-2-yl]-4-methyl-4H-1,2,4-triazol-3-yl}-3-fluorobenzamide
CAS号：
1204178-50-6
MDL Number：
MF(分子式)： C19H16ClF3N4O2 MW(分子量)： 424.8082
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	ASP3662
英文别名	ASP3662; ASP 3662; ASP-3662
CAS号	1204178-50-6
Inchi	InChI=1S/C19H16ClF3N4O2/c1-19(2,29-15-13(22)7-10(20)8-14(15)23)18-26-25-17(27(18)3)11-5-4-9(16(24)28)6-12(11)21/h4-8H,1-3H3,(H2,24,28)
InchiKey	CMQOKZCYVZFZLZ-UHFFFAOYSA-N
分子式 Formula	C19H16ClF3N4O2
分子量 Molecular Weight	424.8082
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	ASP3662(CAS:1204178-50-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	ASP3662 is a novel potent and selective inhibitor of 11β-hsd1
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kiso T, Sekizawa T, Uchino H, Tsukamoto M, Kakimoto S. Analgesic effects of ASP3662, a novel 11β-hydroxysteroid dehydrogenase 1 inhibitor, in rat models of neuropathic and dysfunctional pain. Br J Pharmacol. 2018 Oct;175(19):3784-3796. doi: 10.1111/bph.14448. Epub 2018 Aug 17. PubMed PMID: 30006998; PubMed Central PMCID: PMC6135787.

[2]Bellaire S, Walzer M, Wang T, Krauwinkel W, Yuan N, Marek GJ. Safety, Pharmacokinetics, and Pharmacodynamics of ASP3662, a Novel 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor, in Healthy Young and Elderly Subjects. Clin Transl Sci. 2019 May;12(3):291-301. doi: 10.1111/cts.12618. Epub 2019 Feb 27. PubMed PMID: 30740895; PubMed Central PMCID: PMC6510378.

[3] Baum E, Zhang W, Li S, Cai Z, Holden D, Huang Y. A Novel (18)F-Labeled Radioligand for Positron Emission Tomography Imaging of 11β-Hydroxysteroid Dehydrogenase (11β-HSD1): Synthesis and Preliminary Evaluation in Nonhuman Primates. ACS Chem Neurosci. 2019 May 15;10(5):2450-2458. doi: 10.1021/acschemneuro.8b00715. Epub 2019 Feb 19. PubMed PMID: 30689943.

[4] Gallezot JD, Nabulsi NB, Henry S, Pracitto R, Planeta B, Ropchan J, Lin SF, Labaree D, Kapinos M, Shirali A, Lara-Jaime T, Gao H, Matuskey D, Walzer M, Marek G, Bellaire S, Yuan N, Carson RE, Huang Y. IMAGING THE ENZYME 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 WITH POSITRON EMISSION TOMOGRAPHY: EVALUATION OF THE NOVEL RADIOTRACER (11)C-AS2471907 IN HUMAN BRAIN. J Nucl Med. 2019 Mar 15. pii: jnumed.118.219766. doi: 10.2967/jnumed.118.219766. [Epub ahead of print] PubMed PMID: 30877174.

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