1045-29-0|Anordiol|Dicyclopenta(a,f)naphthalene-1,7-diol, 1,7-diethynylhexadecahydro-8a,10a-dimethyl-, (1R-(1alpha,3abeta,3balpha,5abeta,7alpha,8aalpha,8bbeta,10aalpha))-|-范德生物科技公司

Anordiol

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names：
Dicyclopenta(a,f)naphthalene-1,7-diol, 1,7-diethynylhexadecahydro-8a,10a-dimethyl-, (1R-(1alpha,3abeta,3balpha,5abeta,7alpha,8aalpha,8bbeta,10aalpha))-
CAS号：
1045-29-0
MDL Number：
MF(分子式)： C22H30O2 MW(分子量)： 326.48
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Anordiol
英文别名	Anordiol; AF 45; AF45; AF-45; H 241; H241; H-241
CAS号	1045-29-0
SMILES	O[C@@]1(C#C)CC[C@]2([H])[C@]1(C)CC[C@]3([H])[C@]4(C)[C@@](C[C@](O)(C#C)C4)([H])CC[C@@]23[H]
Inchi	InChI=1S/C22H30O2/c1-5-21(23)13-15-7-8-16-17(19(15,3)14-21)9-11-20(4)18(16)10-12-22(20,24)6-2/h1-2,15-18,23-24H,7-14H2,3-4H3/t15-,16+,17-,18-,19-,20-,21+,22-/m0/s1
InchiKey	HUUUMTTWAPMBMU-ZBJWQKIUSA-N
分子式 Formula	C22H30O2
分子量 Molecular Weight	326.48
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Anordiol(CAS:1045-29-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Anordiol, the dihydroxylated metabolite of anordrin, is an antiestrogen with estrogenic activity that is known to inhibit fertility.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Ma B, Xiang Y, Mu SM, Li T, Yu HM, Li XJ. Effects of acetazolamide and anordiol on osmotic water permeability in AQP1-cRNA injected Xenopus oocyte. Acta Pharmacol Sin. 2004 Jan;25(1):90-7. PubMed PMID: 14704128.

[2]Dao B, Vanage G, Li XJ, Bardin CW, Koide SS. Comparative effectiveness of three antiprogestins alone and in combination with anordiol in terminating pregnancy in the rat. Contraception. 1997 Jan;55(1):35-40. PubMed PMID: 9013059.

[3] Li XJ, Yu H, Koide SS. Effect of mifepristone and antiestrogens on uterine PGF2 alpha and PGE2 concentrations in ovariectomized and pregnant rats. Prostaglandins. 1997 Mar;53(3):187-97. PubMed PMID: 9206800.

[4] Wang WC, Chang CC, Bardin CW. Anordiol is more potent than anordrin for terminating pregnancy when administered with RU 486. Contraception. 1993 Jun;47(6):609-16. PubMed PMID: 8334895.

[5] Juneja SC, Williams RS. Effect of anordrin on the development of mouse preimplantation embryos in vitro. J Assist Reprod Genet. 1996 Apr;13(4):356-62. PubMed PMID: 8777353.

6: Kaplan-Kraicer R, Bardin CW, Shalgi R. Anordiol and RU486 synergize to produce preimplantation pregnancy loss by increasing embryo transport (rat). Contraception. 1995 Feb;51(2):141-6. PubMed PMID: 7750292.7: Kaplan-Kraicer R, Shinnar N, Bardin CW, Shalgi R. Anordiol produces pregnancy loss in the rat--via the embryo or via the uterus? Contraception. 2000 May;61(5):341-6. PubMed PMID: 10906506.8: Chatterton RT Jr, Berman C, Walters NN. Anti-uterotrophic and folliculostatic activities of anordiol (2 alpha,17 alpha-diethynyl-A-nor-5 alpha-androstane-2 beta,17 beta-diol). Contraception. 1989 Mar;39(3):291-7. PubMed PMID: 2714089.9: Peters AJ, Wentz AC, Kazer RR, Jeyendran RS, Chatterton RT Jr. Estrogenic and antiestrogenic activities of anordiol: a comparison of uterine and vaginal responses with those of clomiphene citrate. Contraception. 1995 Sep;52(3):195-202. PubMed PMID: 7587192.10: Vanage GR, Dao B, Li XJ, Bardin CW, Koide SS. Effects of anordiol, an antiestrogen, on the reproductive organs of the male rat. Arch Androl. 1997 Jan-Feb;38(1):13-21. PubMed PMID: 9017118.1

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