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Aniline mustard
- names：
Aniline, N,N-bis(2-chloroethyl)-
- CAS号：
553-27-5
MDL Number： - MF(分子式)： C10H13Cl2N MW(分子量)： 218.12
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|
| 中文别名 | Aniline mustard |
| 英文别名 | Aniline mustard; Lymphocin; Mesylerythrol; NSC-18429 |
| CAS号 | 553-27-5 |
| Inchi | InChI=1S/C10H13Cl2N/c11-6-8-13(9-7-12)10-4-2-1-3-5-10/h1-5H,6-9H2 |
| InchiKey | ROSJKFFLIXTTAW-UHFFFAOYSA-N |
| 分子式 Formula | C10H13Cl2N |
| 分子量 Molecular Weight | 218.12 |
| 溶解度Solubility | |
| 性状 | Solid powder |
| 储藏条件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 产品说明 | Aniline mustard(CAS:553-27-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。 |
| Introduction | Aniline mustard is an alkylating mustard with anti-neoplastic activity. Aniline mustard forms covalent linkages with nucleophilic centers, resulting in depurination, base miscoding and strand scission, and crosslinking of DNA strands, all of which contribute to its cytotoxicity. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Chen CH, Hu TH, Huang TC, Chen YL, Chen YR, Cheng CC, Chen CT. Delineation of G-Quadruplex Alkylation Sites Mediated by 3,6-Bis(1-methyl-4-vinylpyridinium iodide)carbazole-Aniline Mustard Conjugates. Chemistry. 2015 Nov 23;21(48):17379-90. doi: 10.1002/chem.201502595. Epub 2015 Oct 13. PubMed PMID: 26769627. |
| [2]Fedeles BI, Zhu AY, Young KS, Hillier SM, Proffitt KD, Essigmann JM, Croy RG. Chemical genetics analysis of an aniline mustard anticancer agent reveals complex I of the electron transport chain as a target. J Biol Chem. 2011 Sep 30;286(39):33910-20. doi: 10.1074/jbc.M111.278390. Epub 2011 Aug 10. PubMed PMID: 21832047; PubMed Central PMCID: PMC3190774. |
| [3] Benckhuysen C, Ter Hart HG, Van Dijk PJ. Enhanced cytostatic effectiveness of aniline mustard against 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors during regression in response to ovariectomy. Cancer Treat Rep. 1981 Jul-Aug;65(7-8):567-74. PubMed PMID: 6788369. |
| [4] McClean S, Costelloe C, Denny WA, Searcey M, Wakelin LP. Sequence selectivity, cross-linking efficiency and cytotoxicity of DNA-targeted 4-anilinoquinoline aniline mustards. Anticancer Drug Des. 1999 Jun;14(3):187-204. PubMed PMID: 10500495. |
| [5] Gourdie TA, Valu KK, Gravatt GL, Boritzki TJ, Baguley BC, Wakelin LP, Wilson WR, Woodgate PD, Denny WA. DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard. J Med Chem. 1990 Apr;33(4):1177-86. PubMed PMID: 2319563. |
6: Panthananickal A, Hansch C, Leo A. Structure-activity relationship of aniline mustards acting against B-16 melanoma in mice. J Med Chem. 1979 Oct;22(10):1267-9. PubMed PMID: 513075.7: Hansch C, Telzer BR, Zhang L. Comparative QSAR in toxicology: examples from teratology and cancer chemotherapy of aniline mustards. Crit Rev Toxicol. 1995;25(1):67-89. Review. PubMed PMID: 7734060.8: Leo A, Panthananickal A, Hansch C, Theiss J, Shimkin M, Andrews AW. A comparison of mutagenic and carcinogenic activities of aniline mustards. J Med Chem. 1981 Jul;24(7):859-64. PubMed PMID: 7277394.9: Trafalis D, Geromichalou E, Dalezis P, Nikoleousakos N, Sarli V. Synthesis and evaluation of new steroidal lactam conjugates with aniline mustards as potential antileukemic therapeutics. Steroids. 2016 Nov;11
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