4208-09-7|Amorphigenin|(2R,6aS,12aS)-2-(3-hydroxyprop-1-en-2-yl)-8,9-dimethoxy-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one|-范德生物科技公司

Amorphigenin

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names：
(2R,6aS,12aS)-2-(3-hydroxyprop-1-en-2-yl)-8,9-dimethoxy-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one
CAS号：
4208-09-7
MDL Number：
MF(分子式)： C23H22O7 MW(分子量)： 410.42
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Amorphigenin
英文别名	Amorphigenin;
CAS号	4208-09-7
SMILES	O=C1[C@]2([H])[C@](COC3=C2C=C(OC)C(OC)=C3)([H])OC4=C1C=CC5=C4C[C@H](C(CO)=C)O5
Inchi	InChI=1S/C23H22O7/c1-11(9-24)16-7-14-15(29-16)5-4-12-22(25)21-13-6-18(26-2)19(27-3)8-17(13)28-10-20(21)30-23(12)14/h4-6,8,16,20-21,24H,1,7,9-10H2,2-3H3/t16-,20-,21+/m1/s1
InchiKey	ZJMLELXRQUXRIU-HBGVWJBISA-N
分子式 Formula	C23H22O7
分子量 Molecular Weight	410.42
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Amorphigenin(CAS:4208-09-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Amorphigenin is a rotenoid compound which exhibits a strong larvicidal activity.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Ji M, Liang Y, Gu Z, Li X. Inhibitory Effects of Amorphigenin on the Mitochondrial Complex I of Culex pipiens pallens Coquillett (Diptera: Culicidae). Int J Mol Sci. 2015 Aug 20;16(8):19713-27. doi: 10.3390/ijms160819713. PubMed PMID: 26307964; PubMed Central PMCID: PMC4581321.

[2]Liang Y, Li X, Gu Z, Qin P, Ji M. Toxicity of amorphigenin from the seeds of Amorpha fruticosa against the larvae of Culex pipiens pallens (Diptera: Culicidae). Molecules. 2015 Feb 16;20(2):3238-54. doi: 10.3390/molecules20023238. PubMed PMID: 25690287.

[3] Zhong H, Zuo Y, Wu X, Peng Y, He H, Yang J, Guan C, Xu Z. [Synergistic Antitumor Effect of Amorphigenin Combined with Cisplatin in Human Lung Adenocarcinoma A549/DDP Cells]. Zhongguo Fei Ai Za Zhi. 2016 Dec 20;19(12):805-812. Chinese. PubMed PMID: 27978865; PubMed Central PMCID: PMC5973453.

[4] Kim BG, Kwak HB, Choi EY, Kim HS, Kim MH, Kim SH, Choi MK, Chun CH, Oh J, Kim JJ. Amorphigenin inhibits Osteoclast differentiation by suppressing c-Fos and nuclear factor of activated T cells. Anat Cell Biol. 2010 Dec;43(4):310-6. doi: 10.5115/acb.2010.43.4.310. Epub 2010 Dec 31. PubMed PMID: 21267405; PubMed Central PMCID: PMC3026183.

[5] Gyémánt N, Tanaka M, Antus S, Hohmann J, Csuka O, Mándoky L, Molnár J. In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells. In Vivo. 2005 Mar-Apr;19(2):367-74. PubMed PMID: 15796199.

6: Crombie L, Whiting DA. Review article number 135 biosynthesis in the rotenoid group of natural products: applications of isotope methodology. Phytochemistry. 1998 Nov 20;49(6):1479-1507. PubMed PMID: 11711058.7: Sariaslani FS, Rosazza JP. Microbial Transformations of Natural Antitumor Agents: Products of Rotenone and Dihydrorotenone Transformation by Cunninghamella blakesleeana. Appl Environ Microbiol. 1983 Feb;45(2):616-21. PubMed PMID: 16346210; PubMed Central PMCID: PMC242333.8: Earley FG, Ragan CI. Photoaffinity labelling of mitochondrial NADH dehydrogenase with arylazidoamorphigenin, an analogue of rotenone. Biochem J. 1984 Dec 1;224(2):525-34. PubMed PMID: 6517863; PubMed Central PMCID: PMC1144461.9: Li L, Wang HK, Chang JJ, McPhail AT, McPhail DR, Terada H, Konoshima T, Kokumai M, Kozuka M, Estes JR, et al. Antitumor agents, 138. Rotenoids and isoflavones as cytotoxic constitutents from Amorpha fruticosa. J Nat Prod. 1993 May;56(5):690-8. PubMed PMID: 8326318.10: Kloutek E, Popov A, Drenska D, Uzunov P. [Experimental research on the hepatoprotective activity of flavonoids isolated from Amorpha fructiosa]. Eksp Med Morfol. 1985;24(2):50-4. Bulgarian. PubMed PMID: 4065006.1

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