199467-52-2|AM-36|2,6-ditert-butyl-4-[[4-[2-(4-chlorophenyl)-2-hydroxyethyl]piperazin-1-yl]methyl]phenol|-范德生物科技公司

AM-36

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names：
2,6-ditert-butyl-4-[[4-[2-(4-chlorophenyl)-2-hydroxyethyl]piperazin-1-yl]methyl]phenol
CAS号：
199467-52-2
MDL Number：
MF(分子式)： C27H39ClN2O2 MW(分子量)： 459.06
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	AM-36
英文别名	AM-36; AM 36; AM36; UNII-08OBY024NY; SCHEMBL12311270; CNSB 002; CNSB-002; CNSB002;
CAS号	199467-52-2
Inchi	InChI=1S/C27H39ClN2O2/c1-26(2,3)22-15-19(16-23(25(22)32)27(4,5)6)17-29-11-13-30(14-12-29)18-24(31)20-7-9-21(28)10-8-20/h7-10,15-16,24,31-32H,11-14,17-18H2,1-6H3
InchiKey	ZGSFWANJADAZQC-UHFFFAOYSA-N
分子式 Formula	C27H39ClN2O2
分子量 Molecular Weight	459.06
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	AM-36(CAS:199467-52-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	AM-36 is a potent Na+ channel blocker and an antioxidant. AM-36 reduced neutrophil infiltration by approximately 50% in selected brain regions when compared to controls and also modulated macrophage phagocytosis of neutrophils.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Nicolazzo JA, Nguyen TT, Katneni K, Steuten JA, Smith G, Jarrott B, Callaway JK, Charman SA. Pharmacokinetics and brain uptake of AM-36, a novel neuroprotective agent, following intravenous administration to rats. J Pharm Pharmacol. 2008 Feb;60(2):171-8. doi: 10.1211/jpp.60.2.0005. PubMed PMID: 18237464.

[2]Weston RM, Jarrott B, Ishizuka Y, Callaway JK. AM-36 modulates the neutrophil inflammatory response and reduces breakdown of the blood brain barrier after endothelin-1 induced focal brain ischaemia. Br J Pharmacol. 2006 Nov;149(6):712-23. Epub 2006 Oct 3. PubMed PMID: 17016500; PubMed Central PMCID: PMC2014659.

[3] Callaway JK, Castillo-Melendez M, Giardina SF, Krstew EK, Beart PM, Jarrott B. Sodium channel blocking activity of AM-36 and sipatrigine (BW619C89): in vitro and in vivo evidence. Neuropharmacology. 2004 Jul;47(1):146-55. PubMed PMID: 15165842.

[4] Callaway JK, Lawrence AJ, Jarrott B. AM-36, a novel neuroprotective agent, profoundly reduces reactive oxygen species formation and dopamine release in the striatum of conscious rats after endothelin-1-induced middle cerebral artery occlusion. Neuropharmacology. 2003 May;44(6):787-800. PubMed PMID: 12681377.

[5] Callaway JK. Investigation of AM-3

6: a novel neuroprotective agent. Clin Exp Pharmacol Physiol. 2001 Nov;28(11):913-8. Review. PubMed PMID: 11703395.

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