61136-12-7|Almurtide|(4R)-4-((2S)-2-(2-(((3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)acetamido)propanamido)-5-amino-5-oxopentanoic acid|-范德生物科技公司

Almurtide

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names：
(4R)-4-((2S)-2-(2-(((3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)acetamido)propanamido)-5-amino-5-oxopentanoic acid
CAS号：
61136-12-7
MDL Number：
MF(分子式)： C18H30N4O11 MW(分子量)： 478.45
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Almurtide
英文别名	Almurtide; CGP 11637 ; CGP-11637 ; CGP11637; norMDP; norMDP; NacetylnormuramylLalanylDisoglutamine.
CAS号	61136-12-7
SMILES	O=C(O)CC[C@@H](NC([C@@H](NC(CO[C@@H]1[C@@H](NC(C)=O)C(O)O[C@H](CO)[C@H]1O)=O)C)=O)C(N)=O
Inchi	InChI=1S/C18H30N4O11/c1-7(17(30)22-9(16(19)29)3-4-12(26)27)20-11(25)6-32-15-13(21-8(2)24)18(31)33-10(5-23)14(15)28/h7,9-10,13-15,18,23,28,31H,3-6H2,1-2H3,(H2,19,29)(H,20,25)(H,21,24)(H,22,30)(H,26,27)/t7-,9+,10+,13+,14+,15+,18?/m0/s1
InchiKey	KCUSRWLYTAYGAU-KQSQHPHMSA-N
分子式 Formula	C18H30N4O11
分子量 Molecular Weight	478.45
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Almurtide(CAS:61136-12-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Almurtide, also known as romurtide, is a synthetic muramyl dipeptide (MDP) H8analogue with potential immunostimulating and antineoplastic activity. As a derivative of the mycobacterial cell wall component MDP, almurtide activates both monocytes and macrophages. This results in the secretion of cytokines and induces the recruitment and activation of other immune cells, which may result in indirect tumoricidal or cytostatic effects. Check for active clinical trials or closed clinical trials using this agent (NCI Thesaurus).
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Ueda H, Yamazaki M. Induction of tumor necrosis factor-alpha in solid tumor region by the orally administered synthetic muramyl dipeptide analogue, romurtide. Int Immunopharmacol. 2001 Jan;1(1):97-104. PubMed PMID: 11367521.

[2]Yokouchi J, Hirabayashi S, Kanesaka N, Baba S, Amino M, Abe K. [Study on the most appropriate time for Romurtide administration (Nopia) in radiotherapy patients]. Gan To Kagaku Ryoho. 1997 Oct;24(13):1967-73. Japanese. PubMed PMID: 9350244.

[3] Namba K, Yamamura E, Nitanai H, Otani T, Azuma I. Romurtide, a synthetic muramyl dipeptide derivative, promotes megakaryocytopoiesis through stimulation of cytokine production in nonhuman primates with myelosuppression. Vaccine. 1997 Mar;15(4):405-13. PubMed PMID: 9141212.

[4] Namba K, Nitanai H, Otani T, Azuma I. Romurtide, a synthetic muramyl dipeptide derivative, accelerates peripheral platelet recovery in nonhuman primate chemotherapy model. Vaccine. 1996 Oct;14(14):1322-6. PubMed PMID: 9004440.

[5] Namba K, Nakajima R, Otani T, Azuma I. Oral application of romurtide, a synthetic muramyl dipeptide derivative, stimulates nonspecific resistance to microbial infections and hematopoiesis in mice. Vaccine. 1996 Aug;14(12):1149-53. PubMed PMID: 8911012.

6: Yano K, Matsuoka H, Seo Y, Kounoe S, Saito T, Tomoda H. Restorative effect of romurtide for thrombocytopenia associated with intensive anticancer drug treatment and/or irradiation in patients with gastrointestinal cancer. Anticancer Res. 1995 Nov-Dec;15(6B):2883-7. PubMed PMID: 8669883.7: Hasegawa J, Satoh A, Yagi K, Chida K. [Augmentation of immune defense mechanisms of the lung by romurtide]. Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Jun;33(6):605-11. Japanese. PubMed PMID: 7666614.8: Azuma I, Otani T. Potentiation of host defense mechanism against infection by a cytokine inducer, an acyl-MDP derivative, MDP-Lys(L18) (romurtide) in mice and humans. Med Res Rev. 1994 Jul;14(4):401-14. Review. PubMed PMID: 8084203.9: Suzuki K, Torii K, Hida S, Hayashi H, Hiyama Y, Oomoto Y, Takii T, Chiba T, Onozaki K. Differences in interleukin 1 (IL-1), IL-6, tumor necrosis factor and IL-1 receptor antagonist production by human monocytes stimulated with muramyl dipeptide (MDP) and its stearoyl derivative, romurtide. Immunopharmacology. 1994 Jul-Aug;28(1):31-8. PubMed PMID: 7928300.10: Namba K, Otani T, Osada Y. Enhancement of platelet recovery in X-irradiated guinea pigs by romurtide, a synthetic muramyl dipeptide derivative. Blood. 1994 May 1;83(9):2480-8. PubMed PMID: 8167336.

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