239066-73-0|AL-438|10-Methoxy-2,2,4-trimethyl-5-prop-2-enyl-1,5-dihydrochromeno[3,4-f]quinoline|-范德生物科技公司

AL-438

NMR下载 COA and HPLC MSDS下载
names：
10-Methoxy-2,2,4-trimethyl-5-prop-2-enyl-1,5-dihydrochromeno[3,4-f]quinoline
CAS号：
239066-73-0
MDL Number：
MF(分子式)： C23H25NO2 MW(分子量)： 347.45
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	AL-438
英文别名	AL-438; AL 438; AL438;
CAS号	239066-73-0
SMILES	C=CCC(C1=C2C=CC3=C1C(C)=CC(C)(C)N3)OC4=C2C(OC)=CC=C4
Inchi	InChI=1S/C23H25NO2/c1-6-8-18-22-15(21-17(25-5)9-7-10-19(21)26-18)11-12-16-20(22)14(2)13-23(3,4)24-16/h6-7,9-13,18,24H,1,8H2,2-5H3
InchiKey	CZSDJYXNNJQXBB-UHFFFAOYSA-N
分子式 Formula	C23H25NO2
分子量 Molecular Weight	347.45
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	AL-438(CAS:239066-73-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	AL-438 is a non-steroidal selective modulator for the glucocorticoid receptor (GR).
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Reeves EK, Rayavarapu S, Damsker JM, Nagaraju K. Glucocorticoid analogues: potential therapeutic alternatives for treating inflammatory muscle diseases. Endocr Metab Immune Disord Drug Targets. 2012 Mar;12(1):95-103. Review. PubMed PMID: 22214335.

[2]Chopra A. [(11)C]10-Methoxy-5-(2-propenyl)-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3, 4-f]quinoline. 2009 Jan 13 [updated 2009 Apr 6]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from http://www.ncbi.nlm.nih.gov/books/NBK22972/ PubMed PMID: 20641180.

[3] De Bosscher K, Beck IM, Haegeman G. Classic glucocorticoids versus non-steroidal glucocorticoid receptor modulators: survival of the fittest regulator of the immune system? Brain Behav Immun. 2010 Oct;24(7):1035-42. doi: 10.1016/j.bbi.2010.06.010. Epub 2010 Jun 25. Review. PubMed PMID: 20600811.

[4] Xu Y, Zhang T, Chen M. Combining 3D-QSAR, docking, molecular dynamics and MM/PBSA methods to predict binding modes for nonsteroidal selective modulator to glucocorticoid receptor. Bioorg Med Chem Lett. 2009 Jan 15;19(2):393-6. doi: 10.1016/j.bmcl.2008.11.069. Epub 2008 Nov 24. PubMed PMID: 19081253.

[5] Wuest F, Kniess T, Bergmann R, Henry B, Pietzsch J. Synthesis and radiopharmacological characterization of [11C]AL-438 as a nonsteroidal ligand for imaging brain glucocorticoid receptors. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4035-9. Epub 2007 Apr 29. PubMed PMID: 17499506.

6: Owen HC, Miner JN, Ahmed SF, Farquharson C. The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):164-70. Epub 2006 Dec 19. PubMed PMID: 17182172.7: Rosen J, Miner JN. The search for safer glucocorticoid receptor ligands. Endocr Rev. 2005 May;26(3):452-64. Epub 2005 Apr 6. Review. PubMed PMID: 15814846.8: Doggrell S. Is AL-438 likely to have fewer side effects than the glucocorticoids? Expert Opin Investig Drugs. 2003 Jul;12(7):1227-9. PubMed PMID: 12831356.9: Coghlan MJ, Jacobson PB, Lane B, Nakane M, Lin CW, Elmore SW, Kym PR, Luly JR, Carter GW, Turner R, Tyree CM, Hu J, Elgort M, Rosen J, Miner JN. A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects. Mol Endocrinol. 2003 May;17(5):860-9. Epub 2003 Feb 13. PubMed PMID: 12586843.10: Elmore SW, Coghlan MJ, Anderson DD, Pratt JK, Green BE, Wang AX, Stashko MA, Lin CW, Tyree CM, Miner JN, Jacobson PB, Wilcox DM, Lane BC. Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines. J Med Chem. 2001 Dec 6;44(25):4481-91. PubMed PMID: 11728194.

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