124070-15-1|ADCI|10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene-5-carboxamide|-范德生物科技公司

ADCI

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names：
10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene-5-carboxamide
CAS号：
124070-15-1
MDL Number：
MF(分子式)： C16H14N2O MW(分子量)： 250.301
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	ADCI
英文别名	ADCI; SGB-017; SGB017; SGB 017
CAS号	124070-15-1
Inchi	InChI=1S/C16H14N2O/c17-15(19)16-12-7-3-1-5-10(12)9-14(18-16)11-6-2-4-8-13(11)16/h1-8,14,18H,9H2,(H2,17,19)
InchiKey	IFLVGRRVGPXYON-UHFFFAOYSA-N
分子式 Formula	C16H14N2O
分子量 Molecular Weight	250.301
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	ADCI(CAS:124070-15-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	ADCI, also known as SGB-017, is a glutamate receptor antagonist potentially for the treatment of epilepsy. ADCI blocks both voltage-activated sodium channels and N-methyl-D-aspartate (NMDA)-receptor-gated channels. Inhibition of sodium channels by ADCI was voltage dependent. High doses of ADCI increased dopamine metabolism in the prefrontal cortex and/or in the nucleus accumbens, but not in the dorsal striatum.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Sun L, Lin SS. The anticonvulsant SGB-017 (ADCI) blocks voltage-gated sodium channels in rat and human neurons: comparison with carbamazepine. Epilepsia. 2000 Mar;41(3):263-70. PubMed PMID: 10714396.

[2]Geter-Douglass B, Witkin JM. Behavioral effects and anticonvulsant efficacies of low-affinity, uncompetitive NMDA antagonists in mice. Psychopharmacology (Berl). 1999 Oct;146(3):280-9. PubMed PMID: 10541728.

[3] Bubser M, Zadow B, Kronthaler UO, Felsheim U, Rückert NG, Schmidt WJ. Behavioural pharmacology of the non-competitive NMDA antagonists dextrorphan and ADCI: relations between locomotor stimulation, anticataleptic potential and forebrain dopamine metabolism. Naunyn Schmiedebergs Arch Pharmacol. 1997 Jun;355(6):767-73. PubMed PMID: 9205962.

[4] Grant KA, Colombo G, Grant J, Rogawski MA. Dizocilpine-like discriminative stimulus effects of low-affinity uncompetitive NMDA antagonists. Neuropharmacology. 1996;35(12):1709-19. PubMed PMID: 9076750.

[5] Rogawski MA, Le DQ, Uyakul D, Pannell LK, Subramaniam S, Yamaguchi S, Kokate TG. Anticonvulsant efficacy of ADCI (5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine) after acute and chronic dosing in mice. Epilepsia. 1995 Jun;36(6):566-71. PubMed PMID: 7555968.

6: Seidleck BK, Thurkauf A, Witkin JM. Evaluation of ADCI against convulsant and locomotor stimulant effects of cocaine: comparison with the structural analogs dizocilpine and carbamazepine. Pharmacol Biochem Behav. 1994 Apr;47(4):839-44. PubMed PMID: 8029253.7: Grant KA, Snell LD, Rogawski MA, Thurkauf A, Tabakoff B. Comparison of the effects of the uncompetitive N-methyl-D-aspartate antagonist (+-)-5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine (ADCI) with its structural analogs dizocilpine (MK-801) and carbamazepine on ethanol withdrawal seizures. J Pharmacol Exp Ther. 1992 Mar;260(3):1017-22. PubMed PMID: 1545374.8: Rogawski MA, Yamaguchi S, Jones SM, Rice KC, Thurkauf A, Monn JA. Anticonvulsant activity of the low-affinity uncompetitive N-methyl-D- aspartate antagonist (+-)-5-aminocarbonyl-10,11-dihydro-5H- dibenzo[a,d]cyclohepten-5,10-imine (ADCI): comparison with the structural analogs dizocilpine (MK-801) and carbamazepine. J Pharmacol Exp Ther. 1991 Oct;259(1):30-7. PubMed PMID: 1920122.

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