32467-88-2|Acv tripeptide|(S)-2-amino-6-(((R)-1-(((R)-1-carboxy-2-methylpropyl)amino)-3-mercapto-1-oxopropan-2-yl)amino)-6-oxohexanoic acid|-范德生物科技公司

Acv tripeptide

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names：
(S)-2-amino-6-(((R)-1-(((R)-1-carboxy-2-methylpropyl)amino)-3-mercapto-1-oxopropan-2-yl)amino)-6-oxohexanoic acid
CAS号：
32467-88-2
MDL Number：
MF(分子式)： C14H25N3O6S MW(分子量)： 363.42
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Acv tripeptide
英文别名	Acv tripeptide; Acv [MI]; Tripeptides, acv;
CAS号	32467-88-2
Inchi	InChI=1S/C14H25N3O6S/c1-7(2)11(14(22)23)17-12(19)9(6-24)16-10(18)5-3-4-8(15)13(20)21/h7-9,11,24H,3-6,15H2,1-2H3,(H,16,18)(H,17,19)(H,20,21)(H,22,23)/t8-,9-,11+/m0/s1
InchiKey	BYEIJZFKOAXBBV-ATZCPNFKSA-N
分子式 Formula	C14H25N3O6S
分子量 Molecular Weight	363.42
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Acv tripeptide(CAS:32467-88-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Acv tripeptide is a key precursor in penicillin and cephalosporin biosyntheses.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]McNeill LA, Brown TJN, Sami M, Clifton IJ, Burzlaff NI, Claridge TDW, Adlington RM, Baldwin JE, Rutledge PJ, Schofield CJ. Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases. Chemistry. 2017 Sep 18;23(52):12815-12824. doi: 10.1002/chem.201701592. Epub 2017 Aug 2[1]PubMed PMID: 28703303; PubMed Central PMCID: PMC5637899.

[2]Tahlan K, Moore MA, Jensen SE. δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase (ACVS): discovery and perspectives. J Ind Microbiol Biotechnol. 2017 May;44(4-5):517-524. doi: 10.1007/s10295-016-1850-7. Epub 2016 Oct 20. Review. PubMed PMID: 27766439.

[3] Tamanaha E, Zhang B, Guo Y, Chang WC, Barr EW, Xing G, St Clair J, Ye S, Neese F, Bollinger JM Jr, Krebs C. Spectroscopic Evidence for the Two C-H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase. J Am Chem Soc. 2016 Jul 20;138(28):8862-74. doi: 10.1021/jacs.6b04065. Epub 2016 Jul 5. PubMed PMID: 27193226; PubMed Central PMCID: PMC4956533.

[4] Diez-Torrubia A, Cabrera S, de Castro S, García-Aparicio C, Mulder G, De Meester I, Camarasa MJ, Balzarini J, Velázquez S. Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme. Eur J Med Chem. 2013;70:456-68. doi: 10.1016/j.ejmech.2013.10.001. Epub 2013 Oct 9. PubMed PMID: 24185376.

[5] Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ. The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site. FEBS Lett. 2013 Aug 19;587(16):2705-9. doi: 10.1016/j.febslet.2013.07.016. Epub 2013 Jul 13. PubMed PMID: 23860486.

6: Daruzzaman A, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ. The interaction of isopenicillin N synthase with homologated substrate analogues δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography. Chembiochem. 2013 Mar 18;14(5):599-606. doi: 10.1002/cbic.201200728. Epub 2013 Mar 6. PubMed PMID: 23468426.7: Daruzzaman A, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ. The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue. Arch Biochem Biophys. 2013 Feb 1;530(1):48-53. doi: 10.1016/j.abb.2012.12.012. Epub 2012 Dec 19. PubMed PMID: 23262315.8: Fernández-Aguado M, Teijeira F, Martín JF, Ullán RV. A vacuolar membrane protein affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum. Appl Microbiol Biotechnol. 2013 Jan;97(2):795-808. doi: 10.1007/s00253-012-4256-0. Epub 2012 Jul 11. PubMed PMID: 22777282.9: Wu X, García-Estrada C, Vaca I, Martín JF. Motifs in the C-terminal region of the Penicillium chrysogenum ACV synthetase are essential for valine epimerization and processivity of tripeptide formation. Biochimie. 2012 Feb;94(2):354-64. doi: 10.1016/j.biochi.2011.08.002. Epub 2011 Aug 27. PubMed PMID: 21889568.10: Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ. Isopenicillin N synthase binds δ-(L-α-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms. Chembiochem. 2011 Aug 16;12(12):1881-5. doi: 10.1002/cbic.201100149. Epub 2011 Jun 15. PubMed PMID: 21678539.1

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