123548-56-1|Acreozast|((2-chloro-5-cyano-1,3-phenylene)bis(azanediyl))bis(2-oxoethane-2,1-diyl) diacetate|-范德生物科技公司

Acreozast

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names：
((2-chloro-5-cyano-1,3-phenylene)bis(azanediyl))bis(2-oxoethane-2,1-diyl) diacetate
CAS号：
123548-56-1
MDL Number：
MF(分子式)： C15H14ClN3O6 MW(分子量)： 367.74
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Acreozast
英文别名	TYB-2285; TYB2285; TYB 2285
CAS号	123548-56-1
Inchi	InChI=1S/C15H14ClN3O6/c1-8(20)24-6-13(22)18-11-3-10(5-17)4-12(15(11)16)19-14(23)7-25-9(2)21/h3-4H,6-7H2,1-2H3,(H,18,22)(H,19,23)
InchiKey	VNVBCWREJHKWSG-UHFFFAOYSA-N
分子式 Formula	C15H14ClN3O6
分子量 Molecular Weight	367.74
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Acreozast(CAS:123548-56-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Acreozast is a histamine release inhibitor potentially for the treatment of asthma and atopic dermatitis.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Tohda Y, Muraki M, Kubo H, Nakajima S, Fukuoka M, Watanabe A. Effect of TYB-2285 on early and late bronchial responses and airway hyperreactivity in actively sensitized guinea pigs. Gen Pharmacol. 1998 Aug;31(2):323-8. PubMed PMID: 9688481.

[2]Abraham WM, Ahmed A, Cortes A, Sielczak M, Wantanabe A. Effect of TYB-2285 on antigen-induced airway responses in sheep. Pulm Pharmacol. 1996 Feb;9(1):49-58. PubMed PMID: 8843510.

[3] Watanabe A, Tominaga T, Shutoh H, Hayashi H, Tsuji J. Effect of TYB-2285 on peritoneal anaphylaxis in passively sensitized rats. Gen Pharmacol. 1998 Aug;31(2):313-7. PubMed PMID: 9688479.

[4] Tominaga T, Watanbe A, Tsuji J, Koda A, Nagai H, Kumazawa Y, Shimada H. Effect of TYB-2285 on antigen-induced accumulation of eosinophils into the peritoneal cavity of rats sensitized with Ascaris suum extract. Gen Pharmacol. 1997 Mar;28(3):411-4. PubMed PMID: 9068982.

[5] Watanabe A, Tominaga T, Shutoh H, Hayashi H, Tsuji J, Koda A, Nagai H, Kumazawa Y, Shimada H. Effect of TYB-2285 on lung anaphylaxis in actively sensitized rats. Gen Pharmacol. 1997 Feb;28(2):305-9. PubMed PMID: 9013209.

6: Tominaga T, Watanabe A, Tsuji J, Koda A, Nagai H, Kumazawa Y, Shimada H. The effects of TYB-2285 and its metabolites on lymphocyte responses in vitro. Gen Pharmacol. 1997 Sep;29(3):473-5. PubMed PMID: 9378259.7: Kou K, Hayashi M, Nakajima T, Yoshizawa I, Kawano Y, Shikishima Y, Noma T. [Immunomodulation by TYB-2285 of Dermatophagoides farinae (Df) antigen-induced IFN-gamma and IL-4 production in lymphocytes from children with bronchial asthma]. Arerugi. 1997 Jun;46(6):502-10. Japanese. PubMed PMID: 9277001.8: Watanabe A, Tominaga T, Shutoh H, Hayashi H, Tsuji J, Koda A, Nagai H, Kumazawa Y, Shimada H. Effect of TYB-2285 on passive cutaneous anaphylaxis in rats. Gen Pharmacol. 1997 Feb;28(2):311-5. PubMed PMID: 9013210.9: Tominaga T, Watanabe A, Tsuji J, Koda A, Nagai H, Kumazawa Y, Shimada H. Effects of TYB-2285 on the accumulation of eosinophils in the airway induced by antigen exposure in actively sensitized brown Norway rats. Gen Pharmacol. 1997 Feb;28(2):301-3. PubMed PMID: 9013208.10: Ban M, Taguchi H, Katsushima T, Takahashi M, Shinoda K, Watanabe A, Tominaga T. Novel antiallergic and antiinflammatory agents. Part II: Synthesis and pharmacology of TYB-2285 and its related compounds. Bioorg Med Chem. 1998 Jul;6(7):1077-87. PubMed PMID: 9730245.1

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