119290-87-8|Acanthoic acid|1-Phenanthrenecarboxylic acid, 7-ethenyl-1,2,3,4,4a,6,7,8,8a,9,10,10a-dodecahydro-1,4a,7-trimethyl-, (1R-(1alpha,4aalpha,7alpha,8abeta,10abeta))-|-范德生物科技公司

Acanthoic acid

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names：
1-Phenanthrenecarboxylic acid, 7-ethenyl-1,2,3,4,4a,6,7,8,8a,9,10,10a-dodecahydro-1,4a,7-trimethyl-, (1R-(1alpha,4aalpha,7alpha,8abeta,10abeta))-
CAS号：
119290-87-8
MDL Number：
MF(分子式)： C20H30O2 MW(分子量)： 302.46
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Acanthoic acid
英文别名	Acanthoic acid; NP 1302 NP-1302; NP1302
CAS号	119290-87-8
SMILES	O=C([C@]1(C)CCC[C@@]2(C)C3=CC[C@](C)(C=C)C[C@]3([H])CC[C@]12[H])O
Inchi	InChI=1S/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,9,14,16H,1,6-8,10-13H2,2-4H3,(H,21,22)/t14-,16-,18-,19-,20+/m0/s1
InchiKey	TVHDZSRRHQKNEZ-MGFONVBGSA-N
分子式 Formula	C20H30O2
分子量 Molecular Weight	302.46
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Acanthoic acid(CAS:119290-87-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Acanthoic acid is a pimaradiene diterpene isolated from Acanthopanax koreanum. It has been reported to have anti-inflammatory activities. Acanthoic acid downregulates LPS-induced TNF-α, IL-6 and IL-1β production in BALF, attenuates lung histopathologic changes, and inhibits inflammatory cytokines by stopping TNF-α, IL-6 and IL-1β production and NF-κB activation in LPS-stimulated alveolar macrophages.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Qiushi W, Guanghua L, Guangquan X. Acanthoic acid ameliorates lipopolysaccharide-induced acute lung injury. Eur J Pharmacol. 2015 Mar 5;750:32-8. doi: 10.1016/j.ejphar.2015.01.023. Epub 2015 Jan 23. PubMed PMID: 25620130.

[2]Wei C, Tan CK, Xiaoping H, Junqiang J. Acanthoic acid inhibits LPS-induced inflammatory response in human gingival fibroblasts. Inflammation. 2015 Apr;38(2):896-901. doi: 10.1007/s10753-014-0051-7. PubMed PMID: 25373915.

[3] Bai T, Yao YL, Jin XJ, Lian LH, Li Q, Yang N, Jin Q, Wu YL, Nan JX. Acanthoic acid, a diterpene in Acanthopanax koreanum, ameliorates the development of liver fibrosis via LXRs signals. Chem Biol Interact. 2014 Jul 25;218:63-70. doi: 10.1016/j.cbi.2014.04.016. Epub 2014 May 5. PubMed PMID: 24802811.

[4] Través PG, Pimentel-Santillana M, Rico D, Rodriguez N, Miethke T, Castrillo A, Theodorakis EA, Martín-Sanz P, Palladino MA, Boscá L. Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110γ/δ subunits and inhibition of NF-κB. Chem Biol. 2014 Aug 14;21(8):955-66. doi: 10.1016/j.chembiol.2014.06.005. Epub 2014 Jul 24. PubMed PMID: 25065531.

[5] Suwancharoen S, Tommeurd W, Phurat C, Muangsin N, Pornpakakul S. Acanthoic Acid. Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 5;66(Pt 7):o1531. doi: 10.1107/S1600536810019483. PubMed PMID: 21587780; PubMed Central PMCID: PMC3006772.

6: Yoon WJ, Ham YM, Yoon HS, Lee WJ, Lee NH, Hyun CG. Acanthoic acid inhibits melanogenesis through tyrosinase downregulation and melanogenic gene expression in B16 melanoma cells. Nat Prod Commun. 2013 Oct;8(10):1359-62. PubMed PMID: 24354173.7: Wu YL, Jiang YZ, Jin XJ, Lian LH, Piao JY, Wan Y, Jin HR, Joon Lee J, Nan JX. Acanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice. Phytomedicine. 2010 May;17(6):475-9. doi: 10.1016/j.phymed.2009.07.011. PubMed PMID: 19836221.8: Li Y, Zhang XS, Yu JL. Acanthoic acid inhibits LPS-induced inflammatory response by activating LXRα in human umbilical vein endothelial cells. Int Immunopharmacol. 2016 Mar;3

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