107804-48-8|AA 193|Furo(2,3-g)-1,2-benzisoxazole-7-carboxylic acid, 5-chloro-7,8-dihydro-3-phenyl-|-范德生物科技公司

AA 193

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names：
Furo(2,3-g)-1,2-benzisoxazole-7-carboxylic acid, 5-chloro-7,8-dihydro-3-phenyl-
CAS号：
107804-48-8
MDL Number：
MF(分子式)： C16H10ClNO4 MW(分子量)： 315.71
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	AA 193
英文别名	AA 193; AA-193; AA193
CAS号	107804-48-8
Inchi	InChI=1S/C16H10ClNO4/c17-11-6-9-13(8-4-2-1-3-5-8)18-22-14(9)10-7-12(16(19)20)21-15(10)11/h1-6,12H,7H2,(H,19,20)
InchiKey	RVKIPRIYUGLRFF-UHFFFAOYSA-N
分子式 Formula	C16H10ClNO4
分子量 Molecular Weight	315.71
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	AA 193(CAS:107804-48-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	AA 193 is a selective inhibitor of the presecretory reabsorption of uric acid.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Yamada H, Kotaki H, Furitsu H, Sawada Y, Iga T. Mechanism of the uricosuric action of E3040, a drug used to treat inflammatory bowel disease II: study using DBA/2N mice. Biopharm Drug Dispos. 1999 Jul;20(5):271-6. PubMed PMID: 10594872.

[2]Yamada H, Kotaki H, Itoh T, Sawada Y, Iga T. Effect of anti-inflammatory bowel disease drug, E3040, on urate transport in rat renal brush border membrane vesicles. Eur J Pharmacol. 2000 Oct 6;406(1):45-8. PubMed PMID: 11011031.

[3] Lim RW, Furukawa R, Fechheimer M. Evidence of intramolecular regulation of the Dictyostelium discoideum 34 000 Da F-actin-bundling protein. Biochemistry. 1999 Dec 7;38(49):16323-32. PubMed PMID: 10587457.

[4] Dan T, Onuma E, Tanaka H, Koga H. A selective uricosuric action of AA-193 in rats. Comparison with its effect on PAH secretion in vivo and in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1991 May;343(5):532-7. PubMed PMID: 1881462.

[5] Dan T, Koga H, Onuma E, Tanaka H, Sato H, Aoki B. The activity of AA-193, a new uricosuric agent, in animals. Adv Exp Med Biol. 1989;253A:301-8. PubMed PMID: 2624207.

6: Dan T, Yoneya T, Onoma M, Onuma E, Ozawa K. Hypouricemic and uricosuric actions of AA-193 in a hyperuricemic rat model. Metabolism. 1994 Jan;43(1):123-8. PubMed PMID: 8289669.7: Dan T, Tanaka H, Koga H. Mechanism of uricosuric action of AA-193 in DBA/2N mice. J Pharmacol Exp Ther. 1990 May;253(2):437-43. PubMed PMID: 2338641.8: Dan T, Koga H. Uricosurics inhibit urate transporter in rat renal brush border membrane vesicles. Eur J Pharmacol. 1990 Oct 23;187(3):303-12. PubMed PMID: 2073918.9: Kurane I, West K, Tuazon CU, Zeng W, Ennis FA. Definition of two new epitopes on human immunodeficiency virus type 1 gag protein recognized by human CD8+ cytotoxic T lymphocyte clones. J Clin Virol. 2003 May;27(1):38-43. PubMed PMID: 12727527.10: Sato H, Dan T, Onuma E, Tanaka H, Aoki B, Koga H. Studies on uricosuric diuretics. II. Substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids. Chem Pharm Bull (Tokyo). 1991 Jul;39(7):1760-72. PubMed PMID: 1777929. H

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