127875-60-9|A 80915A|2H-Naphtho(2,3-b)pyran-5,10-dione, 3,4a-dichloro-10a-((3-chloro-2,2-dimethyl-6-methylenecyclohexyl)methyl)-3,4,4a,10a-tetrahydro-6,8-dihydroxy-2,2,7-trimethyl-|-范德生物科技公司

A 80915A

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names：
2H-Naphtho(2,3-b)pyran-5,10-dione, 3,4a-dichloro-10a-((3-chloro-2,2-dimethyl-6-methylenecyclohexyl)methyl)-3,4,4a,10a-tetrahydro-6,8-dihydroxy-2,2,7-trimethyl-
CAS号：
127875-60-9
MDL Number：
MF(分子式)： C26H31Cl3O5 MW(分子量)： 529.88
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	A 80915A
英文别名	A 80915A; A-80915A; A80915A;
CAS号	127875-60-9
Inchi	InChI=1S/C26H31Cl3O5/c1-12-7-8-17(27)23(3,4)15(12)10-26-21(32)14-9-16(30)13(2)20(31)19(14)22(33)25(26,29)11-18(28)24(5,6)34-26/h9,15,17-18,30-31H,1,7-8,10-11H2,2-6H3
InchiKey	JCIYFFNGTHMEDE-UHFFFAOYSA-N
分子式 Formula	C26H31Cl3O5
分子量 Molecular Weight	529.88
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	A 80915A(CAS:127875-60-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	A 80915A is A semi-naphthoquinone antibiotic produced by Streptomyces aculeolatus. It is a potent inhibitor of gastric (H(+)-K+)-ATPase, the enzyme responsible for acid secretion in the stomach. Inhibition by A80915A is dependent on the conformation of gastric (H(+)-K+)-ATPase and that potassium slows the rate of inhibition by converting the enzyme to a conformation where the drug binding site is not as accessible.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
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备注

[1]Haste NM, Farnaes L, Perera VR, Fenical W, Nizet V, Hensler ME. Bactericidal kinetics of marine-derived napyradiomycins against contemporary methicillin-resistant Staphylococcus aureus. Mar Drugs. 2011;9(4):680-9. doi: 10.3390/md9040680. Epub 2011 Apr 2[1]PubMed PMID: 21731557; PubMed Central PMCID: PMC3124980.

[2]Ono S, Guntupalli J, DuBose TD Jr. Role of H(+)-K(+)-ATPase in pHi regulation in inner medullary collecting duct cells in culture. Am J Physiol. 1996 May;270(5 Pt 2):F852-61. PubMed PMID: 8928848.

[3] Dantzig AH, Minor PL, Garrigus JL, Fukuda DS, Mynderse JS. Studies on the mechanism of action of A80915A, a semi-naphthoquinone natural product, as an inhibitor of gastric (H(+)-K+)-ATPase. Biochem Pharmacol. 1991 Oct 24; 42(10):2019-26. PubMed PMID: 1683772.

[4] Armitage FE, Wingo CS. Luminal acidification in K-replete OMCDi: inhibition of bicarbonate absorption by K removal and luminal Ba. Am J Physiol. 1995 Jul;269(1 Pt 2):F116-24. PubMed PMID: 7631825.

[5] Armitage FE, Wingo CS. Luminal acidification in K-replete OMCDi: contributions of H-K-ATPase and bafilomycin-A1-sensitive H-ATPase. Am J Physiol. 1994 Sep; 267(3 Pt 2):F450-8. PubMed PMID: 8092259.

6: Zhou X, Xia SL, Wingo CS. Chloride transport by the rabbit cortical collecting duct: dependence on H,K-ATPase. J Am Soc Nephrol. 1998 Dec;9(12):2194-202. PubMed PMID: 9848773.

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