195529-54-5|A-192621|(2R,3R,4S)-4-(benzo[d][1,3]dioxol-5-yl)-1-(2-((2,6-diethylphenyl)amino)-2-oxoethyl)-2-(4-propoxyphenyl)pyrrolidine-3-carboxylic acid|-范德生物科技公司

A-192621

NMR下载 COA and HPLC MSDS下载
names：
(2R,3R,4S)-4-(benzo[d][1,3]dioxol-5-yl)-1-(2-((2,6-diethylphenyl)amino)-2-oxoethyl)-2-(4-propoxyphenyl)pyrrolidine-3-carboxylic acid
CAS号：
195529-54-5
MDL Number：
MF(分子式)： C33H38N2O6 MW(分子量)： 558.675
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	A-192621
英文别名	A-192621; A 192621; A192621; A-192621-1; A-192621.1.
CAS号	195529-54-5
Inchi	InChI=1S/C33H38N2O6/c1-4-16-39-25-13-10-23(11-14-25)32-30(33(37)38)26(24-12-15-27-28(17-24)41-20-40-27)18-35(32)19-29(36)34-31-21(5-2)8-7-9-22(31)6-3/h7-15,17,26,30,32H,4-6,16,18-20H2,1-3H3,(H,34,36)(H,37,38)/t26-,30-,32+/m1/s1
InchiKey	LQEHCKYYIXQEBM-FUKIBTTHSA-N
分子式 Formula	C33H38N2O6
分子量 Molecular Weight	558.675
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	A-192621(CAS:195529-54-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	A-192621 is an endothelin-B antagonist. A-192621 markedly enhanced MAP, TPR, and mesenteric, and the renal constrictor effects of ET-1. A-192621 was more effective than IRL-2500 in blocking IRL-1620-induced vasoconstriction, but both augmented constrictor responses to ET-1.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Wessale JL, Adler AL, Novosad EI, Calzadilla SV, Dayton BD, Marsh KC, Winn M,Jae HS, von Geldern TW, Opgenorth TJ, Wu-Wong JR. Pharmacology of endothelinreceptor antagonists ABT-627, ABT-546, A-182086 and A-19262

[2]ex vivo and in vivostudies. Clin Sci (Lond). 2002 Aug;103 Suppl 48:112S-117S. PubMed PMID: 12193067.

[3]Wu-Wong JR, Dixon DB, Chiou WJ, Sorensen BK, Liu G, Jae HS, Tasker A, vonGeldern TW, Winn M, Opgenorth TJ. Pharmacology of endothelin receptor antagonistsABT-627, ABT-546, A-182086 and A-19262

[4]in vitro studies. Clin Sci (Lond). 2002Aug;103 Suppl 48:107S-111S. PubMed PMID: 12193066.

[5] Leung SW, Lim SL, Pang CC, Man RY. Use of A-192621 and IRL-2500 to unmask themesenteric and renal vasodilator role of endothelin ET(B) receptors. J CardiovascPharmacol. 2002 Apr;39(4):533-43. PubMed PMID: 11904527.

4: Cullen JP, Bell D, Kelso EJ, McDermott BJ. Use of A-192621 to provide evidencefor involvement of endothelin ET(B)-receptors in endothelin-1-mediatedcardiomyocyte hypertrophy. Eur J Pharmacol. 2001 Apr 13;417(3):157-68. PubMedPMID: 11334846.

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