39868-96-7|Clorobiocin|(3R,4S,5R,6S)-6-((8-chloro-4-hydroxy-3-(4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido)-2-oxo-2H-chromen-7-yl)oxy)-5-hydroxy-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl 5-methyl-1H-pyrrole-2-carboxylate|-范德生物科技公司

Clorobiocin

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names：
(3R,4S,5R,6S)-6-((8-chloro-4-hydroxy-3-(4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido)-2-oxo-2H-chromen-7-yl)oxy)-5-hydroxy-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl 5-methyl-1H-pyrrole-2-carboxylate
CAS号：
39868-96-7
MDL Number：
MF(分子式)： C35H37ClN2O11 MW(分子量)： 697.13
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Clorobiocin
英文别名	Clorobiocin; RP 18631; RP-18631; RP18631;
CAS号	39868-96-7
Inchi	InChI=1S/C35H37ClN2O11/c1-16(2)7-9-18-15-19(10-13-22(18)39)31(42)38-25-26(40)20-11-14-23(24(36)28(20)47-33(25)44)46-34-27(41)29(30(45-6)35(4,5)49-34)48-32(43)21-12-8-17(3)37-21/h7-8,10-15,27,29-30,34,37,39-41H,9H2,1-6H3,(H,38,42)/t27-,29+,30-,34-/m1/s1
InchiKey	FJAQNRBDVKIIKK-LFLQOBSNSA-N
分子式 Formula	C35H37ClN2O11
分子量 Molecular Weight	697.13
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Clorobiocin(CAS:39868-96-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Clorobiocin is an aminocoumarin antibacterial that inhibits the enzyme DNA gyrase.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Rückert C, Kalinowski J, Heide L, Apel AK. Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin. Genome Announc. 2014 Jan 9;2(1). pii: e01147-13. doi: 10.1128/genomeA.01147-13. PubMed PMID: 24407645; PubMed Central PMCID: PMC3886958.

[2]Flinspach K, Westrich L, Kaysser L, Siebenberg S, Gomez-Escribano JP, Bibb M, Gust B, Heide L. Heterologous expression of the biosynthetic gene clusters of coumermycin A(1), clorobiocin and caprazamycins in genetically modified Streptomyces coelicolor strains. Biopolymers. 2010 Sep;93(9):823-32. doi: 10.1002/bip.21493. PubMed PMID: 20578003.

[3] Eustáquio AS, Gust B, Luft T, Li SM, Chater KF, Heide L. Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs. Chem Biol. 2003 Mar;10(3):279-88. PubMed PMID: 12670542.

[4] Freitag A, Wemakor E, Li SM, Heide L. Acyl transfer in clorobiocin biosynthesis: involvement of several proteins in the transfer of the pyrrole-2-carboxyl moiety to the deoxysugar. Chembiochem. 2005 Dec;6(12):2316-25. PubMed PMID: 16276503.

[5] Wolpert M, Gust B, Kammerer B, Heide L. Effects of deletions of mbtH-like genes on clorobiocin biosynthesis in Streptomyces coelicolor. Microbiology. 2007 May;153(Pt 5):1413-23. PubMed PMID: 17464055.

6: Pojer F, Li SM, Heide L. Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics. Microbiology. 2002 Dec;148(Pt 12):3901-11. PubMed PMID: 12480894.7: Xu H, Kahlich R, Kammerer B, Heide L, Li SM. CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin. Microbiology. 2003 Aug;149(Pt 8):2183-91. PubMed PMID: 12904558.8: Westrich L, Heide L, Li SM. CloN6, a novel methyltransferase catalysing the methylation of the pyrrole-2-carboxyl moiety of clorobiocin. Chembiochem. 2003 Aug 4;4(8):768-73. PubMed PMID: 12898629.9: Galm U, Heller S, Shapiro S, Page M, Li SM, Heide L. Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis. Antimicrob Agents Chemother. 2004 Apr;48(4):1307-12. PubMed PMID: 15047534; PubMed Central PMCID: PMC375324.10: Anderle C, Alt S, Gulder T, Bringmann G, Kammerer B, Gust B, Heide L. Biosynthesis of clorobiocin: investigation of the transfer and methylation of the pyrrolyl-2-carboxyl moiety. Arch Microbiol. 2007 Mar;187(3):227-37. Epub 2006 Nov 25. PubMed PMID: 17308937.1

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