101363-10-4|Rufloxacin|9-Fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzothiazine-6-carboxylic acid|-范德生物科技公司

Rufloxacin

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names：
9-Fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzothiazine-6-carboxylic acid
CAS号：
101363-10-4
MDL Number：
MF(分子式)： C17H18FN3O3S MW(分子量)： 363.4074
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	9-Fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzothiazine-6-carboxylic acid
英文别名	Rufloxacin; MF 934
CAS号	101363-10-4
SMILES	O=C(C(C1=O)=CN2CCSC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O
Inchi	InChI=1S/C17H18FN3O3S/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)25-7-6-21(13)9-11(15(10)22)17(23)24/h8-9H,2-7H2,1H3,(H,23,24)
InchiKey	NJCJBUHJQLFDSW-UHFFFAOYSA-N
分子式 Formula	C17H18FN3O3S
分子量 Molecular Weight	363.4074
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Rufloxacin(CAS:101363-10-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Rufloxacin belongs to the class of fluoroquinolones that act mainly as specific inhibitors of bacterial Topoisomerase II. These drugs are widely known to be involved in various diseases ranging from cutaneous reactions to aging.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Gismondo MR, Drago L, Lombardi A, Fassina C, Cesana M. Impact of rufloxacin and ciprofloxacin on the intestinal microflora in a germ-free mice model. Chemotherapy. 1995 Jul-Aug;41(4):281-8. PubMed PMID: 7555209.

[2]Lazzaroni M, Imbimbo BP, Bargiggia S, Sangaletti O, Dal Bo L, Broccali G, Bianchi Porro G. Effects of magnesium-aluminum hydroxide antacid on absorption of rufloxacin. Antimicrob Agents Chemother. 1993 Oct;37(10):2212-6. PubMed PMID: 8257146; PubMed Central PMCID: PMC192252.

[3] Gu LY, Lin WW, Lu H, Chen XY, Ge ZZ, Li XB. Quadruple therapy with medications containing either rufloxacin or furazolidone as a rescue regimen in the treatment of Helicobacter pylori-infected dyspepsia patients: a randomized pilot study. Helicobacter. 2011 Aug;16(4):284-8. doi: 10.1111/j.1523-5378.2011.00848.x. PubMed PMID: 21762267.

[4] Catalfo A, Scifo C, Stella S, Belvedere A, Renis M, De Guidi G. Rufloxacin induced photosensitization in bio-models of increasing complexity. Photochem Photobiol Sci. 2005 Mar;4(3):304-14. Epub 2005 Feb 2. PubMed PMID: 15739000.

[5] Jardin A, Cesana M. Randomized, double-blind comparison of single-dose regimens of rufloxacin and pefloxacin for acute uncomplicated cystitis in women. French Multicenter Urinary Tract Infection-Rufloxacin Group. Antimicrob Agents Chemother. 1995 Jan;39(1):215-20. PubMed PMID: 7695309; PubMed Central PMCID: PMC162511.

6: Carlucci G, Mazzeo P, Palumbo G. Simultaneous determination of rufloxacin, fenbufen and felbinac in human plasma using high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1996 Jul 12;682(2):315-9. PubMed PMID: 8844425.7: Wise R, Andrews JM, Matthews R, Wolstenholme M. The in-vitro activity of two new quinolones: rufloxacin and MF 961. J Antimicrob Chemother. 1992 Jun;29(6):649-60. PubMed PMID: 1324239.8: Del Río G, Dalet F, Aguilar L, Caffaratti J, Dal-Ré R. Single-dose rufloxacin versus 3-day norfloxacin treatment of uncomplicated cystitis: clinical evaluation and pharmacodynamic considerations. Antimicrob Agents Chemother. 1996 Feb;40(2):408-12. PubMed PMID: 8834888; PubMed Central PMCID: PMC163124.9: Cuffini AM, Tullio V, Allocco A, Paizis G, De Leo C, Carlone NA. Effect of rufloxacin upon non-specific immune defences: in-vitro, ex-vivo and in-vivo results. J Antimicrob Chemother. 1994 Oct;34(4):545-53. PubMed PMID: 7868406.10: Catalfo A, Calandra ML, Renis M, Serrentino ME, De Guidi G. Rufloxacin-induced photosensitization in yeast. Photochem Photobiol Sci. 2007 Feb;6(2):181-9. Epub 2007 Jan 2. PubMed PMID: 17277842.1

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