111902-57-9|Temocapril|1,4-Thiazepine-4(5H)-acetic acid, 6-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)tetrahydro-5-oxo-2-(2-thienyl)-, (2S-(2alpha,6beta(R*)))-|-范德生物科技公司

Temocapril

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names：
1,4-Thiazepine-4(5H)-acetic acid, 6-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)tetrahydro-5-oxo-2-(2-thienyl)-, (2S-(2alpha,6beta(R*)))-
CAS号：
111902-57-9
MDL Number：
MF(分子式)： C23H28N2O5S2 MW(分子量)： 476.606
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	1,4-Thiazepine-4(5H)-acetic acid, 6-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)tetrahydro-5-oxo-2-(2-thienyl)-, (2S-(2alpha,6beta(R*)))-
英文别名	Temocapril
CAS号	111902-57-9
Inchi	InChI=1S/C23H28N2O5S2/c1-2-30-23(29)17(11-10-16-7-4-3-5-8-16)24-18-15-32-20(19-9-6-12-31-19)13-25(22(18)28)14-21(26)27/h3-9,12,17-18,20,24H,2,10-11,13-15H2,1H3,(H,26,27)/t17?,18-,20-/m0/s1
InchiKey	FIQOFIRCTOWDOW-WSTRIDTPSA-N
分子式 Formula	C23H28N2O5S2
分子量 Molecular Weight	476.606
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Temocapril(CAS:111902-57-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Temocapril is a tyrosine kinase inhibitor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Mishima E, Hashimoto J, Akiyama Y, Seiji K, Takase K, Abe T, Ito S. Posterior reversible encephalopathy syndrome treated with renin-angiotensin system blockade. J Neurol Sci. 2015 Aug 15;355(1-2):219-2[1]doi: 10.1016/j.jns.2015.06.007. PubMed PMID: 26073482.

[2]Funahashi Y, Sassa N, Inada-Inoue M, Ando Y, Matsukawa Y, Gotoh M. Acute aortic dissection in a patient receiving multiple tyrosine kinase inhibitors for 5 years. Aktuelle Urol. 2014 Mar;45(2):132-4. doi: 10.1055/s-0033-1363274. PubMed PMID: 24700069.

[3] Ohura K, Tasaka K, Hashimoto M, Imai T. Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine. Drug Metab Dispos. 2014 Feb;42(2):264-73. doi: 10.1124/dmd.113.054551. PubMed PMID: 24271336.

[4] Ohnishi K, Murase M, Nakano D, Pelisch N, Hitomi H, Kobori H, Morimoto S, Mori H, Masaki T, Ohmori K, Kohno M, Ichihara A, Nishiyama A. Angiotensin-converting enzyme inhibitor does not suppress renal angiotensin II levels in angiotensin I-infused rats. J Pharmacol Sci. 2013;122(2):103-8. PubMed PMID: 23698111; PubMed Central PMCID: PMC3786864.

[5] Yamamoto D, Takai S, Akimoto T, Hirahara I, Ito C, Muto S, Kusano E. Matrix metalloproteinase-2 inhibition by temocapril and its important role in peritoneal transport. Clin Exp Pharmacol Physiol. 2012 Oct;39(10):864-8. doi: 10.1111/j.1440-1681.2012.12003.x. PubMed PMID: 23013132.

6: Bahar FG, Ohura K, Ogihara T, Imai T. Species difference of esterase expression and hydrolase activity in plasma. J Pharm Sci. 2012 Oct;101(10):3979-88. doi: 10.1002/jps.23258. PubMed PMID: 22833171.7: Ohura K, Nozawa T, Murakami K, Imai T. Evaluation of transport mechanism of prodrugs and parent drugs formed by intracellular metabolism in Caco-2 cells with modified carboxylesterase activity: temocapril as a model case. J Pharm Sci. 2011 Sep;100(9):3985-94. doi: 10.1002/jps.22628. PubMed PMID: 21618543.8: Nozawa T, Imai T. Prediction of human intestinal absorption of the prodrug temocapril by in situ single-pass perfusion using rat intestine with modified hydrolase activity. Drug Metab Dispos. 2011 Jul;39(7):1263-9. doi: 10.1124/dmd.110.037937. PubMed PMID: 21474683.9: Maruyoshi H, Baba T, Ogata J, Nagata S. [A ten-year follow-up of a 109-year-old woman with myocardial infarction]. Nihon Ronen Igakkai Zasshi. 2011;48(1):78-83. Japanese. PubMed PMID: 21378469.10: Hobara N, Goda M, Hashikawa N, Jin X, Zamami Y, Takatori S, Kawasaki H. [Role of angiontensin receptors in remodeling perivascular nerves]. Yakugaku Zasshi. 2010 Nov;130(11):1421-5. Review. Japanese. PubMed PMID: 21048398.1

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