126347-69-1|R-82913|(S)-4-chloro-8-methyl-7-(3-methylbut-2-en-1-yl)-6,7,8,9-tetrahydro-2,7,9a-triazabenzo[cd]azulene-1(2H)-thione|-范德生物科技公司

R-82913

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names：
(S)-4-chloro-8-methyl-7-(3-methylbut-2-en-1-yl)-6,7,8,9-tetrahydro-2,7,9a-triazabenzo[cd]azulene-1(2H)-thione
CAS号：
126347-69-1
MDL Number：
MF(分子式)： C16H20ClN3S MW(分子量)： 321.867
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(S)-4-chloro-8-methyl-7-(3-methylbut-2-en-1-yl)-6,7,8,9-tetrahydro-2,7,9a-triazabenzo[cd]azulene-1(2H)-thione
英文别名	R-82913; R 82913; R82913. 9-Cmbib; NSC 637653, 9-Cl-Tibo.
CAS号	126347-69-1
Inchi	InChI=1S/C16H20ClN3S/c1-10(2)4-5-19-9-12-6-13(17)7-14-15(12)20(8-11(19)3)16(21)18-14/h4,6-7,11H,5,8-9H2,1-3H3,(H,18,21)/t11-/m0/s1
InchiKey	RCSLUNOLLUVOOG-NSHDSACASA-N
分子式 Formula	C16H20ClN3S
分子量 Molecular Weight	321.867
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	R-82913(CAS:126347-69-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	R-82913, also known as 9-Cmbib; NSC 637653, 9-Cl-Tibo, is a RNA-directed DNA polymerase inhibitor potentially for the treatment of HIV infection. R 82913 reduce 5-HT2 receptor-mediated DOI-head-shakes in mice. R82913 inhibited the replication of thirteen different strains of HIV-1 in CEM cells with a median IC50 of 0.15 microM. R82913 was 20-fold more potent than AZT-TP in the inhibition of HIV-1 reverse transcriptase in an assay. R82913 has no effect on the replication of HIV-2 in CEM cells and does not inhibit the reverse transcriptase from this virus.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Vandamme AM, Debyser Z, Pauwels R, De Vreese K, Goubau P, Youle M, Gazzard B,Stoffels PA, Cauwenbergh GF, Anne J, et al. Characterization of HIV-1 strainsisolated from patients treated with TIBO R82913. AIDS Res Hum Retroviruses. 1994Jan;10(1):39-46. PubMed PMID: 7514016.

[2]Geissler RG, Ganser A, Ottmann OG, Kojouharoff G, Reutzel P, Andries K,Schellekens K, Hoelzer D. TIBO R82913, a new HIV-1 inhibiting agent, does notinhibit hematopoietic progenitor cells. AIDS Res Hum Retroviruses. 1991Dec;7(12):1021-3. PubMed PMID: 1812943.

[3] White EL, Buckheit RW Jr, Ross LJ, Germany JM, Andries K, Pauwels R, JanssenPA, Shannon WM, Chirigos MA. A TIBO derivative, R82913, is a potent inhibitor ofHIV-1 reverse transcriptase with heteropolymer templates. Antiviral Res. 1991Oct;16(3):257-66. PubMed PMID: 1725247.

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