145216-43-9|Forasartan|5-[(3,5-dibutyl-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-tetrazol-5-yl)phenyl]pyridine|-范德生物科技公司

Forasartan

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names：
5-[(3,5-dibutyl-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-tetrazol-5-yl)phenyl]pyridine
CAS号：
145216-43-9
MDL Number：
MF(分子式)： C23H28N8 MW(分子量)： 416.52
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Forasartan
英文别名	Forasartan; SC-52458; SC 52458; SC52458.
CAS号	145216-43-9
Inchi	InChI=1S/C23H28N8/c1-3-5-11-21-25-22(12-6-4-2)31(28-21)16-17-13-14-20(24-15-17)18-9-7-8-10-19(18)23-26-29-30-27-23/h7-10,13-15H,3-6,11-12,16H2,1-2H3,(H,26,27,29,30)
InchiKey	YONOBYIBNBCDSJ-UHFFFAOYSA-N
分子式 Formula	C23H28N8
分子量 Molecular Weight	416.52
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Forasartan(CAS:145216-43-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Forasartan is a nonpeptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan competes with angiotensin II for binding at the AT1 receptor subtype in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction resulting in vascular dilatation. In addition, the antagonistic effect on AT1 in the adrenal gland, prevents angiotensin II-induced stimulation of aldosterone synthesis and secretion by the adrenal cortex.
Application1
Application2
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kushiku K, Yamada H, Shibata K, Tokunaga R, Katsuragi T, Furukawa T.Upregulation of immunoreactive angiotensin II release and angiotensinogen mRNAexpression by high-frequency preganglionic stimulation at the canine cardiacsympathetic ganglia. Circ Res. 2001 Jan 19;88(1):110-6. PubMed PMID: 11139482.

[2]Aki Y, Tomohiro A, Nishiyama A, Kiyomoto K, Kimura S, Abe Y. The role ofbasally synthesized nitric oxide in modulating the renal vasoconstrictor actionof angiotensin II. Hypertens Res. 1997 Dec;20(4):251-6. PubMed PMID: 9453259.

[3] McMahon EG, Yang PC, Babler MA, Suleymanov OD, Palomo MA, Olins GM, Cook CS.Effects of SC-52458, an angiotensin AT1 receptor antagonist, in the dog. Am JHypertens. 1997 Jun;10(6):671-7. PubMed PMID: 9194514.

[4] Usune S, Furukawa T. Effects of SC-52458, a new nonpeptide angiotensin IIreceptor antagonist, on increase in cytoplasmic Ca2+ concentrations andcontraction induced by angiotensin II and K(+)-depolarization in guinea-pigtaenia coli. Gen Pharmacol. 1996 Oct;27(7):1179-85. PubMed PMID: 8981065.

[5] Ohta K, Kim S, Hamaguchi A, Yukimura T, Miura K, Takaori K, Iwao H. Role ofangiotensin II in extracellular matrix and transforming growth factor-beta 1expression in hypertensive rats. Eur J Pharmacol. 1994 Sep 15;269(1):115-9.PubMed PMID: 7828653.

6: Olins GM, Corpus VM, Chen ST, McMahon EG, Palomo MA, McGraw DE, Smits GJ, NullCL, Brown MA, Bittner SE, et al. Pharmacology of SC-52458, an orally active,nonpeptide angiotensin AT1 receptor antagonist. J Cardiovasc Pharmacol. 1993Oct;22(4):617-25. PubMed PMID: 7505365.7: de la Hoz JC. [Bee (Apis mellifera, Hymenoptera: Apoidea) visitation tocantaloupe Cucumis melo (Cucurvitaceae) flowers in Panama]. Rev Biol Trop. 2007Jun;55(2):677-80. Spanish. PubMed PMID: 19069779.8: Krovat EM, Langer T. Non-peptide angiotensin II receptor antagonists: chemicalfeature based pharmacophore identification. J Med Chem. 2003 Feb 27;46(5):716-26.PubMed PMID: 12593652.9: Katsuragi T, Sato C, Guangyuan L, Honda K. Inositol(1,4,5)trisphosphate signaltriggers a receptor-mediated ATP release. Biochem Biophys Res Commun. 2002 May3;293(2):686-90. PubMed PMID: 12054523.10: Hagmann M, Nussberger J, Naudin RB, Burns TS, Karim A, Waeber B, Brunner HR.SC-52458, an orally active angiotensin II-receptor antagonist: inhibition ofblood pressure response to angiotensin II challenges and pharmacokinetics innormal volunteers. J Cardiovasc Pharmacol. 1997 Apr;29(4):444-50. PubMed PMID:9156352.1

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