38677-81-5|吡布特罗|Pirbuterol|-范德生物科技公司

吡布特罗

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names：
Pirbuterol
CAS号：
38677-81-5
MDL Number：
MF(分子式)： C12H20N2O3 MW(分子量)： 240.2988
EINECS: Reaxys Number:
Pubchem ID:4845 Brand:BIOFOUNT

吡布特罗(38677-81-5,Pirbuterol)是一种具有支气管扩张剂活性的短效β-肾上腺素能受体激动剂。

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中文别名	吡布特罗,哌替洛尔,吡丁醇
英文别名	Pirbuterol
CAS号	38677-81-5
SMILES	CC(C)(C)NCC(O)C1=NC(CO)=C(O)C=C1
Inchi	InChI=1S/C12H20N2O3/c1-12(2,3)13-6-11(17)8-4-5-10(16)9(7-15)14-8/h4-5,11,13,15-17H,6-7H2,1-3H3
InchiKey	VQDBNKDJNJQRDG-UHFFFAOYSA-N
分子式 Formula	C12H20N2O3
分子量 Molecular Weight	240.2988
闪点 FP	NA
熔点 Melting point	NA
沸点 Boiling point	NA
Polarizability极化度	4
密度 Density	NA
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid
储藏条件 Storage conditions	干燥阴凉处存储

Pirbuterol使用注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品时尽量采用多个药勺分别使用，使用后清洗干净。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
大规格定制：定制产品请将信息发送至sales@bio-fount.com。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

产品说明	吡布特罗(38677-81-5,Pirbuterol)是一种具有支气管扩张剂活性的短效β-肾上腺素能受体激动剂。
Introduction	Pirbuterol(38677-81-5,吡布特罗)is a short-acting, beta-adrenergic receptor agonist with bronchodilator activity.
Application1	Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established.
Application2	吡布特罗也称为maxair，属于称为羟基吡啶的有机化合物
Application3	吡布特罗是含有在一个或多个位置被羟基取代的吡啶环的有机化合物

Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established. The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3? ,5?-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.

Pirbuterol is a short-acting, beta-adrenergic receptor agonist with bronchodilator activity. Pirbuterol selectively binds to beta-2 adrenergic receptors in bronchial smooth muscle, thereby activating intracellular adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle, relieve bronchospasms, improve mucociliary clearance and inhibit the release of mediators of immediate hypersensitivity from cells, especially from mast cells.Pirbuterol, also known as maxair, belongs to the class of organic compounds known as hydroxypyridines. These are organic compounds containing a pyridine ring substituted at one or more positions by a hydroxyl group.

警示图
危险性
危险性警示	warning
安全声明
安全防护
备注	实验过程中防止吸入、食如，做好安全防护

Ocular hypotension in the rabbit. Receptor mechanisms of pirbuterol and nylidrin PMID 2857689; Investigative ophthalmology & visual science 1985 Feb; 26(2):163-9

Pirbuterol, an oral beta-adrenergic receptor agonist, in the treatment of chronic cardiac failure PMID 6128086; Circulation 1982 Dec; 66(6):1262-7

Pirbuterol in the treatment of bronchial asthma PMID 367975; International journal of clinical pharmacology and biopharmacy 1979 Jan; 17(1):18-25

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