113-18-8|Ethchlorvynol|(E)-1-chloro-3-ethylpent-1-en-4-yn-3-ol|-范德生物科技公司

Ethchlorvynol

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names：
(E)-1-chloro-3-ethylpent-1-en-4-yn-3-ol
CAS号：
113-18-8
MDL Number：
MF(分子式)： C7H9ClO MW(分子量)： 144.6
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Ethchlorvynol
英文别名	Ethchlorvynol; Ethchlorovynol; Placidyl; Ethchlorvinol; Ethclorvynol; Alvinol;
CAS号	113-18-8
Inchi	InChI=1S/C7H9ClO/c1-3-7(9,4-2)5-6-8/h1,5-6,9H,4H2,2H3/b6-5+/t7-/m1/s1
InchiKey	ZEHYJZXQEQOSON-WEWAHIQMSA-N
分子式 Formula	C7H9ClO
分子量 Molecular Weight	144.6
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Ethchlorvynol(CAS:113-18-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Ethchlorvynol is discontinued (DEA controlled substance). Ethchlorvynol is a sedative and hypnotic used in short-term management of insomnia. Ethchlorvynol depresses the central nervous system by binding at a benzodiazepine-GABA-A-chloride ionophore receptor complex, located in the limbic, thalamic and hypothalamic regions of the central nervous system (CNS). This increases the frequency of chloride channel opening, allowing the flow of chloride ions into the neuron and ultimately leading to membrane hyperpolarization and a decrease in neuronal excitability.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Sprague RS, Stephenson AH, McMurdo L, Lonigro AJ. Inhibition of nitric oxidesynthesis improves arterial oxygenation in ethchlorvynol-induced acute lunginjury in dogs. Pol J Pharmacol. 1995 Sep-Oct;47(5):473-8. PubMed PMID: 8868143.

[2]Nakatsuka M, Gehr LC, Glauser FL. The effects of amrinone and calcium chlorideon pulmonary vasculature and biventricular function in ethchlorvynol-induced lunginjury in sheep. Acta Anaesthesiol Scand. 1993 Feb;37(2):219-22. PubMed PMID:8447214.

[3] Zanaboni PB, Bradley JD, Webster RO, Dahms TE. Cyclooxygenase inhibitorsprevent ethchlorvynol-induced injury in rat and rabbit lungs. J Appl Physiol(1985). 1991 Jul;71(1):43-9. PubMed PMID: 1917763.

[4] Miller KS, Harley RA, Sahn SA. Pleural effusions associated with ethchlorvynollung injury result from visceral pleural leak. Am Rev Respir Dis. 1989Sep;140(3):764-70. PubMed PMID: 2782746.

[5] Winek CL, Wahba WW, Rozin L, Winek CL Jr. Determination of ethchlorvynol inbody tissues and fluids after embalmment. Forensic Sci Int. 1988 May;37(3):161-6.PubMed PMID: 3402856.

6: Kolpek JH, Parr MD, Marshall ML, Flueck JA. Ethchlorvynol pharmacokineticsduring long-term administration in a patient with hyperlipidemia andhypothyroidism. Pharmacotherapy. 1986 Nov-Dec;6(6):323-7. PubMed PMID: 3822854.7: Sprague RS, Stephenson AH, Dahms TE, Lonigro AJ. Effect of cyclooxygenaseinhibition on ethchlorvynol-induced acute lung injury in dogs. J Appl Physiol(1985). 1986 Sep;61(3):1058-64. PubMed PMID: 3093450.8: Bridges RR, Jennison TA. Analysis of ethchlorvynol (Placidyl): evaluation of acomparison performed in a clinical laboratory. J Anal Toxicol. 1984Nov-Dec;8(6):263-8. PubMed PMID: 6521435.9: Stephenson AH, Sprague RS, Dahms TE, Lonigro AJ. Unilateral acute lung injuryinduced by ethchlorvynol in anesthetized dogs. J Appl Physiol Respir EnvironExerc Physiol. 1984 May;56(5):1252-9. PubMed PMID: 6725085.10: Fekety KB, Medwick T. Quantitative analysis of ethchlorvynol in a capsuledosage form by NMR spectroscopy. J Pharm Sci. 1983 Nov;72(11):1358-60. PubMedPMID: 6644607.1

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