19044-88-3|氨磺乐灵|Oryzalin|MFCD00078725-范德生物科技公司

氨磺乐灵

NMR下载 COA and HPLC MSDS下载
names：
Oryzalin
CAS号：
19044-88-3
MDL Number： MFCD00078725
MF(分子式)： C12H18N4O6S MW(分子量)： 346
EINECS:242-777-0 Reaxys Number:
Pubchem ID:29393 Brand:BIOFOUNT

氨磺乐灵(19044-88-3,Oryzalin)是一种磺酰胺，是在3和5位被硝基取代而在4位被二丙基氨基取代的苯磺酰胺。氨磺乐灵具有除草剂，农药和抗有丝分裂作用。氨磺乐灵是磺酰胺，C-硝基化合物，芳族胺和叔氨基化合物。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
WSH49542-1mL	1mL	95%	¥ 183.00	¥ 183.00		Backorder	- +	¥ 0.00

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中文别名	氨磺乐灵(19044-88-3,Oryzalin);消草磺灵;氨磺灵;黄草消;N,N-二丙基-4-氨基磺酰基-2,6-硝基苯胺;氟醚菌酰胺;3,5-二硝基-N4,N4-丙基磺胺
英文别名	Oryzalin(19044-88-3);4-(Dipropylamino)-3,5-dinitrobenzenesulfonamide;Surflan;Dirimal;Dirimal Extra
CAS号	19044-88-3
Inchi	InChI=1S/C12H18N4O6S/c1-3-5-14(6-4-2)12-10(15(17)18)7-9(23(13,21)22)8-11(12)16(19)20/h7-8H,3-6H2,1-2H3,(H2,13,21,22)
InchiKey	UNAHYJYOSSSJHH-UHFFFAOYSA-N
分子式 Formula	C12H18N4O6S
分子量 Molecular Weight	346
溶解度Solubility
性状	橙黄色结晶固体
储藏条件 Storage conditions	storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)

氨磺乐灵(19044-88-3,Oryzalin)毒理属性测试：

生物	测试类型	路线	报告剂量（标准化剂量）	参考
rat	LD50	oral	10000 mg/kg (10000 mg/kg)	Agricultural Chemicals, Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision, 2(44), 1977
mouse	LD50	oral	>10 gm/kg (10000 mg/kg)	Agrochemicals Handbook, with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86, A305(1983)
dog	LD50	oral	>1 gm/kg (1000 mg/kg)	Pesticide Manual., 9(632), 1991
cat	LD50	oral	1 gm/kg (1000 mg/kg)	Pesticide Manual., 9(632), 1991
rabbit	LD50	skin	>2 gm/kg (2000 mg/kg)	Pesticide Manual., 9(632), 1991

氨磺乐灵(19044-88-3,Oryzalin) 实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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产品说明	氨磺乐灵(19044-88-3,Oryzalin)仅做科学研究以及化学合成中间体使用,19044-88-3其他参数见主页。
Introduction	Sulfalin (19044-88-3,氨磺乐灵) is only used for scientific research and chemical synthesis intermediates. See the homepage for other parameters of 19044-88-3.
Application1	可以用作除草剂
Application2
Application3

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

象形图
信号	Warning
GHS危险说明	H317 (99.18%): May cause an allergic skin reaction [Warning Sensitization, Skin] H400 (36.33%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (99.18%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
防范说明代码	P261, P272, P273, P280, P302+P352, P321, P333+P313, P363, P391, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

Oryzalin bodies: in addition to its anti-microtubule properties, the dinitroaniline herbicide oryzalin causes nodulation of the endoplasmic reticulum(Protoplasma,2009)

Inhibition of intracellular Ca2+ signalling, cytotoxicity and antitumor activity of the herbicide oryzalin and its analogues(Cancer Chemotherapy and Pharmacology,1997)

Identification of the Herbicide Surflan and Its Active Ingredient Oryzalin, a Dinitrosulfonamide, as Xenoestrogens(Archives of Environmental Contamination and Toxicology,2005)

Chromosome doubling in a Rosa rugosa Thunb. hybrid by exposure of in vitro nodes to oryzalin: the effects of node length, oryzalin concentration and exposure time(Plant Cell Reports,2007)

Oryzalin-induced chromosome doubling in Rosa and its effect on plant morphology and pollen viability(Theoretical and Applied Genetics,2003)

1.Quantitative analysis of microtubule orientation in interdigitated leaf pavement cells.
Akita K1, Higaki T, Kutsuna N, Hasezawa S. Plant Signal Behav. 2015;10(5):e1024396. doi: 10.1080/15592324.2015.1024396.
Leaf pavement cells are shaped like a jigsaw puzzle in most dicotyledon species. Molecular genetic studies have identified several genes required for pavement cells morphogenesis and proposed that microtubules play crucial roles in the interdigitation of pavement cells. In this study, we performed quantitative analysis of cortical microtubule orientation in leaf pavement cells in Arabidopsis thaliana. We captured confocal images of cortical microtubules in cotyledon leaf epidermis expressing GFP-tubulinβ and quantitatively evaluated the microtubule orientations relative to the pavement cell growth axis using original image processing techniques. Our results showed that microtubules kept parallel orientations to the growth axis during pavement cell growth. In addition, we showed that immersion treatment of seed cotyledons in solutions containing tubulin polymerization and depolymerization inhibitors decreased pavement cell complexity. Treatment with oryzalin and colchicine inhibited the symmetric division of guard mother cells.

2.Liposomes versus lipid nanoparticles: comparative study of lipid-based systems as oryzalin carriers for the treatment of leishmaniasis.
Lopes RM, Gaspar MM, Pereira J, Eleutério CV, Carvalheiro M, Almeida AJ, Cruz ME. J Biomed Nanotechnol. 2014 Dec;10(12):3647-57.
Main-stay in treatment of leishmaniasis relies on chemotherapy but none of the current drugs combines high activity and low toxicity at affordable costs. Dinitroanilines are a new class of drugs with proved in vitro antileishmanial activity. However the development of their pharmaceutical formulations has been compromised by low water solubility and low accumulation in diseased organs. These limitations can be overcome by incorporation in lipid-based nanoformulations such as liposomes and solid lipid nanoparticles. In previous work this strategy was already followed with the incorporation of a dinitroaniline, oryzalin, resulting in the improvement of the biodistribution profile. The present work aims at demonstrating the in vitro and in vivo therapeutic activity of these oryzalin nanoformulations, and establishing a systematic comparison of both systems. After oryzalin incorporation suitable physicochemical properties for parenteral administration were obtained.

3.Convoluted Plasma Membrane Domains in the Green Alga Chara are Depleted of Microtubules and Actin Filaments.
Sommer A1, Hoeftberger M1, Hoepflinger MC1, Schmalbrock S1, Bulychev A2, Foissner I3. Plant Cell Physiol. 2015 Oct;56(10):1981-96. doi: 10.1093/pcp/pcv119. Epub 2015 Aug 12.
Charasomes are convoluted plasma membrane domains in the green alga Chara australis. They harbor H(+)-ATPases involved in acidification of the medium, which facilitates carbon uptake required for photosynthesis. In this study we investigated the distribution of cortical microtubules and cortical actin filaments in relation to the distribution of charasomes. We found that microtubules and actin filaments were largely lacking beneath the charasomes, suggesting the absence of nucleating and/or anchoring complexes or an inhibitory effect on polymerization. We also investigated the influence of cytoskeleton inhibitors on the light-dependent growth and the darkness-induced degradation of charasomes. Inhibition of cytoplasmic streaming by cytochalasin D significantly inhibited charasome growth and delayed charasome degradation, whereas depolymerization of microtubules by oryzalin or stabilization of microtubules by paclitaxel had no effect. Our data indicate that the membrane at the cytoplasmic surface of charasomes has different properties in comparison with the smooth plasma membrane.

4.Arabidopsis FH1 Formin Affects Cotyledon Pavement Cell Shape by Modulating Cytoskeleton Dynamics.
Rosero A1, Oulehlová D2, Stillerová L3, Schiebertová P3, Grunt M3, ?árský V2, Cvr?ková F4. Plant Cell Physiol. 2016 Mar;57(3):488-504. doi: 10.1093/pcp/pcv209. Epub 2016 Jan 6.
Plant cell morphogenesis involves concerted rearrangements of microtubules and actin microfilaments. We previously reported that FH1, the main Arabidopsis thaliana housekeeping Class I membrane-anchored formin, contributes to actin dynamics and microtubule stability in rhizodermis cells. Here we examine the effects of mutations affecting FH1 (At3g25500) on cell morphogenesis and above-ground organ development in seedlings, as well as on cytoskeletal organization and dynamics, using a combination of confocal and variable angle epifluorescence microscopy with a pharmacological approach. Homozygous fh1 mutants exhibited cotyledon epinasty and had larger cotyledon pavement cells with more pronounced lobes than the wild type. The pavement cell shape alterations were enhanced by expression of the fluorescent microtubule marker GFP-microtubule-associated protein 4 (MAP4). Mutant cotyledon pavement cells exhibited reduced density and increased stability of microfilament bundles, as well as enhanced dynamics of microtubules.

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