188791-09-5|JTE 607 dihydrochloride|JTE 607 dihydrochloride|-范德生物科技公司

JTE 607 dihydrochloride

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names：
JTE 607 dihydrochloride
CAS号：
188791-09-5
MDL Number：
MF(分子式)： C22H29Cl4N3O3 MW(分子量)： 525.292
EINECS:Not available Reaxys Number:No data available
Pubchem ID:9938544 Brand:BIOFOUNT

JTE-607是炎症细胞因子合成的抑制剂。它α抑制LPS刺激的分离人外周血单核细胞（PBMC;IC50s = 11、5.9、8.8、7.3 和 9.1 nM）。JTE-607 在无细胞测定中与裂解和聚腺苷酸化特异性因子 3 （CPSF3）结合，这是一种参与前 mRNA 的 3'-末端加工的酶，并诱导 CXCL8 前 mRNA 在 LPS 刺激的 SC 细胞中的积累。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
HCC324796-5mg	5mg	98.42%	¥ 988.00	¥ 988.00		1-3days	- +	¥ 0.00

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询价

中文别名	188791-09-5;JTE 607二盐酸盐;甲氧番荔枝碱
英文别名	JTE-607; JTE 607; JTE 607; JTE-607 HCl; JTE-607 dihydrochloride;unii-2b68h6bwcx;
CAS号	188791-09-5
SMILES	O=C(N(CC)C1=CC=CC=C1)C2=CC(Cl)=C(OCCN3CCN(C)CC3)C(Cl)=C2O.[H]Cl.[H]Cl
Inchi	InChI=1S/C22H27Cl2N3O3.2ClH/c1-3-27(16-7-5-4-6-8-16)22(29)17-15-18(23)21(19(24)20(17)28)30-14-13-26-11-9-25(2)10-12-26;;/h4-8,15,28H,3,9-14H2,1-2H3;2*1H
InchiKey	XKZDDHOZPMTNEZ-UHFFFAOYSA-N
分子式 Formula	C22H29Cl4N3O3
分子量 Molecular Weight	525.292
闪点 FP	No data available
熔点 Melting point	No data available
沸点 Boiling point	No data available
Polarizability极化度	No data available
密度 Density	No data available
蒸汽压 Vapor Pressure	No data available
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	JTE-607是炎症细胞因子合成的抑制剂。它α抑制LPS刺激的分离人外周血单核细胞（PBMC;IC50s = 11、5.9、8.8、7.3 和 9.1 nM）。JTE-607 在无细胞测定中与裂解和聚腺苷酸化特异性因子 3 （CPSF3）结合，这是一种参与前 mRNA 的 3'-末端加工的酶，并诱导 CXCL8 前 mRNA 在 LPS 刺激的 SC 细胞中的积累。
Introduction	JTE-607 is an inhibitor of inflammatory cytokine synthesis. It inhibits the production of TNF-α, IL-1β, IL-6, IL-8, and IL-10 in LPS-stimulated isolated human peripheral blood mononuclear cells (PBMCs
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Borozdenkova S, Mant TG, Allen E, Pu K, Hoshino S, Jurcevic S. Effects of a cytokine inhibitor, JTE-607, on the response to endotoxin in healthy human volunteers. Int Immunopharmacol. 2011 Nov;11(11):1837-43. doi: 10.1016/j.intimp.2011.07.013. PubMed PMID: 21820084.

[2]Tajima N, Fukui K, Uesato N, Maruhashi J, Yoshida T, Watanabe Y, Tojo A. JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. Cancer Sci. 2010 Mar;101(3):774-81. doi: 10.1111/j.1349-7006.2009.01446.x. PubMed PMID: 20028380.

[3] Asaga T, Ueki M, Chujo K, Taie S. JTE-607, an inflammatory cytokine synthesis inhibitor, attenuates ischemia/reperfusion-induced renal injury by reducing neutrophil activation in rats. J Biosci Bioeng. 2008 Jul;106(1):22-6. doi: 10.1263/jbb.106.22. PubMed PMID: 18691526.

[4] Uesato N, Fukui K, Maruhashi J, Tojo A, Tajima N. JTE-607, a multiple cytokine production inhibitor, ameliorates disease in a SCID mouse xenograft acute myeloid leukemia model. Exp Hematol. 2006 Oct;34(10):1385-92. PubMed PMID: 16982331.

[5] Iwamura H, Sato M, Wakitani K. Comparative study of glucocorticoids, cyclosporine A, and JTE-607 [(-)-Ethyl-N[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]- L-phenylalaninate dihydrochloride] in a mouse septic shock model. J Pharmacol Exp Ther. 2004 Dec;311(3):1256-63. PubMed PMID: 15280441.

6: Ryugo M, Sawa Y, Ono M, Miyamoto Y, Aleshin AN, Matsuda H. Pharmacologic preconditioning of JTE-607, a novel cytokine inhibitor, attenuates ischemia-reperfusion injury in the myocardium. J Thorac Cardiovasc Surg. 2004 Jun;127(6):1723-7. PubMed PMID: 15173729.7: Jian MY, Koizumi T, Tsushima K, Kubo K. JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats. Eur J Pharmacol. 2004 Mar 19;488(1-3):231-8. PubMed PMID: 15044056.8: Iwamura H, Inushima K, Takeuchi K, Kakutani M, Wakitani K. Prophylactic effect of JTE-607 on LPS-induced acute lung injury in rats with CINC-1 inhibition. Inflamm Res. 2002 Mar;51(3):160-6. PubMed PMID: 12005207.9: Kakutani M, Takeuchi K, Waga I, Iwamura H, Wakitani K. JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. Inflamm Res. 1999 Aug;48(8):461-8. PubMed PMID: 10493164.10: Sasaki J, Fujishima S, Iwamura H, Wakitani K, Aiso S, Aikawa N. Prior burn insult induces lethal acute lung injury in endotoxemic mice: effects of cytokine inhibition. Am J Physiol Lung Cell Mol Physiol. 2003 Feb;284(2):L270-8. PubMed PMID: 12388363.

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