188791-09-5|JTE 607 dihydrochloride|JTE 607 dihydrochloride|-范德生物科技公司

JTE 607 dihydrochloride

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names：
JTE 607 dihydrochloride
CAS号：
188791-09-5
MDL Number：
MF(分子式)： C22H29Cl4N3O3 MW(分子量)： 525.292
EINECS:Not available Reaxys Number:No data available
Pubchem ID:9938544 Brand:BIOFOUNT

JTE-607是炎症细胞因子合成的抑制剂。它α抑制LPS刺激的分离人外周血单核细胞（PBMC;IC50s = 11、5.9、8.8、7.3 和 9.1 nM）。JTE-607 在无细胞测定中与裂解和聚腺苷酸化特异性因子 3 （CPSF3）结合，这是一种参与前 mRNA 的 3'-末端加工的酶，并诱导 CXCL8 前 mRNA 在 LPS 刺激的 SC 细胞中的积累。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
HCC324796-5mg	5mg	98.42%	¥ 988.00	¥ 988.00		1-3days	- +	¥ 0.00

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询价

中文别名	188791-09-5;JTE 607二盐酸盐;甲氧番荔枝碱
英文别名	JTE-607; JTE 607; JTE 607; JTE-607 HCl; JTE-607 dihydrochloride;unii-2b68h6bwcx;
CAS号	188791-09-5
Inchi	InChI=1S/C22H27Cl2N3O3.2ClH/c1-3-27(16-7-5-4-6-8-16)22(29)17-15-18(23)21(19(24)20(17)28)30-14-13-26-11-9-25(2)10-12-26;;/h4-8,15,28H,3,9-14H2,1-2H3;2*1H
InchiKey	XKZDDHOZPMTNEZ-UHFFFAOYSA-N
分子式 Formula	C22H29Cl4N3O3
分子量 Molecular Weight	525.292
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	JTE-607是炎症细胞因子合成的抑制剂。它α抑制LPS刺激的分离人外周血单核细胞（PBMC;IC50s = 11、5.9、8.8、7.3 和 9.1 nM）。JTE-607 在无细胞测定中与裂解和聚腺苷酸化特异性因子 3 （CPSF3）结合，这是一种参与前 mRNA 的 3'-末端加工的酶，并诱导 CXCL8 前 mRNA 在 LPS 刺激的 SC 细胞中的积累。
Introduction	JTE-607 is an inhibitor of inflammatory cytokine synthesis. It inhibits the production of TNF-α, IL-1β, IL-6, IL-8, and IL-10 in LPS-stimulated isolated human peripheral blood mononuclear cells (PBMCs
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Borozdenkova S, Mant TG, Allen E, Pu K, Hoshino S, Jurcevic S. Effects of a cytokine inhibitor, JTE-607, on the response to endotoxin in healthy human volunteers. Int Immunopharmacol. 2011 Nov;11(11):1837-43. doi: 10.1016/j.intimp.2011.07.013. PubMed PMID: 21820084.

[2]Tajima N, Fukui K, Uesato N, Maruhashi J, Yoshida T, Watanabe Y, Tojo A. JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. Cancer Sci. 2010 Mar;101(3):774-81. doi: 10.1111/j.1349-7006.2009.01446.x. PubMed PMID: 20028380.

[3] Asaga T, Ueki M, Chujo K, Taie S. JTE-607, an inflammatory cytokine synthesis inhibitor, attenuates ischemia/reperfusion-induced renal injury by reducing neutrophil activation in rats. J Biosci Bioeng. 2008 Jul;106(1):22-6. doi: 10.1263/jbb.106.22. PubMed PMID: 18691526.

[4] Uesato N, Fukui K, Maruhashi J, Tojo A, Tajima N. JTE-607, a multiple cytokine production inhibitor, ameliorates disease in a SCID mouse xenograft acute myeloid leukemia model. Exp Hematol. 2006 Oct;34(10):1385-92. PubMed PMID: 16982331.

[5] Iwamura H, Sato M, Wakitani K. Comparative study of glucocorticoids, cyclosporine A, and JTE-607 [(-)-Ethyl-N[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]- L-phenylalaninate dihydrochloride] in a mouse septic shock model. J Pharmacol Exp Ther. 2004 Dec;311(3):1256-63. PubMed PMID: 15280441.

6: Ryugo M, Sawa Y, Ono M, Miyamoto Y, Aleshin AN, Matsuda H. Pharmacologic preconditioning of JTE-607, a novel cytokine inhibitor, attenuates ischemia-reperfusion injury in the myocardium. J Thorac Cardiovasc Surg. 2004 Jun;127(6):1723-7. PubMed PMID: 15173729.7: Jian MY, Koizumi T, Tsushima K, Kubo K. JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats. Eur J Pharmacol. 2004 Mar 19;488(1-3):231-8. PubMed PMID: 15044056.8: Iwamura H, Inushima K, Takeuchi K, Kakutani M, Wakitani K. Prophylactic effect of JTE-607 on LPS-induced acute lung injury in rats with CINC-1 inhibition. Inflamm Res. 2002 Mar;51(3):160-6. PubMed PMID: 12005207.9: Kakutani M, Takeuchi K, Waga I, Iwamura H, Wakitani K. JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. Inflamm Res. 1999 Aug;48(8):461-8. PubMed PMID: 10493164.10: Sasaki J, Fujishima S, Iwamura H, Wakitani K, Aiso S, Aikawa N. Prior burn insult induces lethal acute lung injury in endotoxemic mice: effects of cytokine inhibition. Am J Physiol Lung Cell Mol Physiol. 2003 Feb;284(2):L270-8. PubMed PMID: 12388363.

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