222638-67-7|BEC HCl|S-(2-boronoethyl)-L-cysteine hydrochloride|-范德生物科技公司

BEC HCl

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names：
S-(2-boronoethyl)-L-cysteine hydrochloride
CAS号：
222638-67-7
MDL Number：
MF(分子式)： C5H13BClNO4S MW(分子量)： 229.482
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	BEC HCl
英文别名	BEC HCl; S-(2-boronoethyl)-L-cysteine.
CAS号	222638-67-7
Inchi	InChI=1S/C5H12BNO4S.ClH/c7-4(5(8)9)3-12-2-1-6(10)11;/h4,10-11H,1-3,7H2,(H,8,9);1H/t4-;/m0./s1
InchiKey	GHPYJLCQYMAXGG-WCCKRBBISA-N
分子式 Formula	C5H13BClNO4S
分子量 Molecular Weight	229.482
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	BEC HCl(CAS:222638-67-7 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	BEC, also known as S-(2-boronoethyl)-L-cysteine, is an a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM (ph 7.5). BEC significantly enhances NO-dependent relaxation of human penile corpus canvernosum smooth muscle in vitro at concentrations between 0.1-1.0 mM. S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Kim NN, Cox JD, Baggio RF, Emig FA, Mistry SK, Harper SL, Speicher DW, Morris SM Jr, Ash DE, Traish A, Christianson DW. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001 Mar 6;40(9):2678-88. PubMed PMID: 11258879.

[2]Kim SH, Langford ML, Boucher JL, Testerman TL, McGee DJ. Helicobacter pylori arginase mutant colonizes arginase II knockout mice. World J Gastroenterol. 2011 Jul 28;17(28):3300-9. doi: 10.3748/wjg.v17.i28.3300. PubMed PMID: 21876618; PubMed Central PMCID: PMC3160534.

[3] Martens CR, Kuczmarski JM, Lennon-Edwards S, Edwards DG. Impaired L-arginine uptake but not arginase contributes to endothelial dysfunction in rats with chronic kidney disease. J Cardiovasc Pharmacol. 2014 Jan;63(1):40-8. doi: 10.1097/FJC.0000000000000022. PubMed PMID: 24084210.

[4] You H, Gao T, Cooper TK, Morris SM Jr, Awad AS. Arginase inhibition: a new treatment for preventing progression of established diabetic nephropathy. Am J Physiol Renal Physiol. 2015 Sep 1;309(5):F447-55. doi: 10.1152/ajprenal.00137.2015. PubMed PMID: 26041444; PubMed Central PMCID: PMC4556892.

[5] You H, Gao T, Cooper TK, Morris SM Jr, Awad AS. Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism. Kidney Int. 2013 Dec;84(6):1189-97. doi: 10.1038/ki.2013.215. PubMed PMID: 23760286; PubMed Central PMCID: PMC3783645.

6: Pudlo M, Demougeot C, Girard-Thernier C. Arginase Inhibitors: A Rational Approach Over One Century. Med Res Rev. 2016 Nov 15. doi: 10.1002/med.21419. [Epub ahead of print] Review. PubMed PMID: 27862081.7: Bordage S, Pham TN, Zedet A, Gugglielmetti AS, Nappey M, Demougeot C, Girard-Thernier C. Investigation of Mammal Arginase Inhibitory Properties of Natural Ubiquitous Polyphenols by Using an Optimized Colorimetric Microplate Assay. Planta Med. 2016 Oct 24. [Epub ahead of print] PubMed PMID: 27776374.8: Chu Y, XiangLi X, Niu H, Wang H, Jia P, Gong W, Wu D, Qin W, Xing C. Arginase inhibitor attenuates pulmonary artery hypertension induced by hypoxia. Mol Cell Biochem. 2016 Jan;412(1-2):91-9. doi: 10.1007/s11010-015-2611-z. PubMed PMID: 26608181.9: Ohnaka M, Okuda-Ashitaka E, Kaneko S, Ando A, Maeda M, Furuta K, Suzuki M, Takahashi K, Ito S. Induction of arginase II mRNA by nitric oxide using an in vitro model of gyrate atrophy of choroid and retina. Invest Ophthalmol Vis Sci. 2011 Mar 18;52(3):1493-500. doi: 10.1167/iovs.10-5516. PubMed PMID: 20811048.10: McLarren KW, Cole AE, Weisser SB, Voglmaier NS, Conlin VS, Jacobson K, Popescu O, Boucher JL, Sly LM. SHIP-deficient mice develop spontaneous intestinal inflammation and arginase-dependent fibrosis. Am J Pathol. 2011 Jul;179(1):180-8. doi: 10.1016/j.ajpath.2011.03.018. PubMed PMID: 21640975; PubMed Central PMCID: PMC3123870.1

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