购物车 
-
血红蛋白
NMR and HPLC COA下载 MSDS下载 - Names：
Hemoglobin
- CAS号：
9008-02-0
MDL Number： MFCD00131282 - MF(分子式)： C13H10N2O2 MW(分子量)： 226.2307
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
血红蛋白(9008-02-0,Hemoglobin)是高等生物体内负责运载氧的一种蛋白质(缩写为Hb或HGB)。血红蛋白是使血液呈红色的蛋白。血红蛋白由四条链组成，两条α链和两条β链，每一条链有一个包含一个铁原子的环状血红素。氧气结合在铁原子上，被血液运输。血红蛋白的特性是：在氧含量高的地方，容易与氧结合；在氧含量低的地方，又容易与氧分离。血红蛋白的这一特性，使红细胞具有运输氧的功能。血红蛋白每一血红蛋白分子由四分子的珠蛋白和四分子亚铁血红素组成，每个血红素又由4个吡咯环组成，在环中央有一个铁原子。
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| SS8024-25g | 25g | 来源于牛血液 | ¥ 526.00 | ¥ 526.00 | 2-3days | ¥ 0.00 | ||
| SS8024-5g | 5g | 来源于牛血液 | ¥ 266.00 | ¥ 266.00 | 2-3days | ¥ 0.00 | ||
| SS8024-1g | 1g | 来源于牛血液 | ¥ 96.00 | ¥ 96.00 | 2-3days | ¥ 0.00 |
| 中文别名 | 血红蛋白(9008-02-0,Hemoglobin);牛血红蛋白;高铁血红蛋白;血红蛋白 来源于牛血液;血红蛋白(牛血);血色蛋白;血色素 |
| 英文别名 | Hemoglobin(9008-02-0),Hemoglobin powder,Hemoglobin from porcine blood |
| CAS号 | 9008-02-0 |
| Inchi | InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-; |
| InchiKey | KABFMIBPWCXCRK-RGGAHWMASA-L |
| 分子式 Molecular Weight | C13H10N2O2 |
| 分子量 Formula | 226.2307 |
| 溶解度Solubility | 0.6 M HCl: soluble20mg/mL |
| 性状 | 红褐色固体粉末 |
| 储藏条件 Storage conditions | 2-8℃ |
血红蛋白(9008-02-0,Hemoglobin)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品时尽量采用多个药勺分别使用，使用后清洗干净后，烘干消毒存放。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
Hemoglobin(9008-02-0) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:血红蛋白(9008-02-0,Hemoglobin),血红蛋白试剂,血红蛋白的作用,血红蛋白的含量,血红蛋白的外观,血红蛋白的简称,血红蛋白的合成,血红蛋白的作用机制,血红蛋白的生产,血红蛋白的使用,血红蛋白的注意事项
| 产品说明 | 血红蛋白(9008-02-0)也叫血色素,血红蛋白是血液中一种含铁和蛋白质的红色化合物,血红蛋白溶解度,血红蛋白msds,血红蛋白结构式详见主页. |
| Introduction | Hemoglobin (9008-02-0,血红蛋白) is also called hemoglobin. Hemoglobin is a red compound in the blood containing iron and protein. |
| Application1 | 血红蛋白(9008-02-0,Hemoglobin)用于生化研究，可破细胞壁。 |
| Application2 | 血液可以借助血红蛋白从肺泡中吸取氧气输送给体内各个组织，又从体内各个组织把二氧化碳带回肺脏，排出体外 |
| Application3 | 血红蛋白与红细胞的使用价值近似，血红蛋白的升高和降低可参考红细胞升高与降低的临床意义 |
血红蛋白(9008-02-0,Hemoglobin)的生理性变异和病理性变异大致上与红细胞是相同的。但在各种贫血时红细胞与血红蛋白的减少不一定呈平行关系。血红蛋白中的铁在二价状态时，可与氧呈可逆性结合(氧合血红蛋白)，如果铁氧化为三价状态。血红蛋白则转变为高铁血红蛋白，就失去了载氧能力。珠蛋白约占96%，血红素占4%。α和β都类似于肌红蛋白，只是肽链稍短：α亚基为141aa；β亚基为146aa。α和β亚基隔着一个空腔彼此相向。在哺乳动物中，血红蛋白占红细胞干重的97%、总重的35%。平均每克血红蛋白可结合1.34ml的氧气，是血浆溶氧量的70~73倍。
血红蛋白是脊椎动物红血细胞的一种含铁的复合变构蛋白，由血红素和珠蛋白结合而成。其功能是运输氧和二氧化碳，维持血液酸碱平衡。也存在于某些低等动物和豆科植物根瘤中。分子量约67 000，含有四条多肽链，每个多肽链含有一个血红素基团，血红素中铁为二价，与氧结合时，其化学价不变，形成氧合血红蛋白。呈鲜红色，与氧解离后带有淡蓝色。
有多种类型：血红蛋白A(HbA)，α2β2，占成人血红蛋白的98%；
血红蛋白A2(HbA2)，α2δ2，占成人血红蛋白的2%；
血红蛋白F(HbF)，α2γ2，仅存在于胎儿血中；血红蛋白H(HbH)，β4，四个相同β链组成的四聚体血红蛋白；血红蛋白C(HbC)，β链中Lys被Glu取代的血红蛋白；血红蛋白S(HbS)，镰刀状细胞红蛋白；血红蛋白O2(HbO2，HHbO2)，氧合血红蛋白；
血红蛋白CO(HbCO)，一氧化碳结合血红蛋白。
在没有氧存在的情况下，四个亚基之间相互作用的力很强。
氧分子越多与血红蛋白结合力越强。
中心离子铁(II)进一步和蛋白质链中的组氨酸结合，成为五配位。既是配位中心，又是活性中心。血红蛋白中铁(II)能可逆地结合氧分子，取决于氧分压。它能从氧分压较高的肺泡中摄取氧，并随着血液循环把氧气释放到氧分压较低的组织中去，从而起到输氧作用。一氧化碳与血红蛋白的结合较氧强，即使浓度很低也能优先和血红蛋白结合，致使通往组织的氧气流中断，造成一氧化碳中毒（使氧气与血红蛋白的结合能力下降，使人窒息而死亡）。
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | No data available |
| 安全声明 | H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害 |
| 安全防护 | P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理 |
| 备注 | 实验过程中防止吸入、食入，做好安全防护 |
| Cation-exchange high-performance liquid chromatography for variant hemoglobins and HbF/A2: What must hematopathologists know about methodology? |
| Hemoglobinopathies in the ukurova Region and Neighboring Provinces. |
| Inaccurate pulse CO-oximetry of carboxyhemoglobin due to digital clubbing: case report. |
[BLUE BABY, PINK FUTURE].Osovsky M, Yacobovich J, Sirota L, Tamary H. Harefuah. 2016 Jan;155(1):24-6, 68.
Abstract:Neonatal cyanosis is relatively common. It is usually a consequence of cyanotic heart disease or a pulmonary disorder, and warrants a thorough and quick investigation. Mutations causing decreased affinity of hemoglobin to oxygen may change α1 to β2 binding. We describe a new mutation (asp 102 serine), in the γ chain of hemoglobin, causing neonatal cyanosis which resolves as the baby matures. In this case we would like to emphasize the importance of early diagnosis in order to avoid unnecessary disease workup.
Cation-exchange high-performance liquid chromatography for variant hemoglobins and HbF/A2: What must hematopathologists know about methodology?Sharma P1, Das R1. World J Methodol. 2016 Mar 26;6(1):20-4. doi: 10.5662/wjm.v6.i1.20. eCollection 2016.
Abstract:Cation-exchange high-performance liquid chromatography (CE-HPLC) is a widely used laboratory test to detect variant hemoglobins as well as quantify hemoglobins F and A2 for the diagnosis of thalassemia syndromes. It's versatility, speed, reproducibility and convenience have made CE-HPLC the method of choice to initially screen for hemoglobin disorders. Despite its popularity, several methodological aspects of the technology remain obscure to pathologists and this may have consequences in specific situations. This paper discusses the basic principles of the technique, the initial quality control steps and the interpretation of various controls and variables that are available on the instrument output. Subsequent sections are devoted to methodological considerations that arise during reporting of cases. For instance, common problems of misidentified peaks, totals crossing 100%, causes of total area being above or below acceptable limits and the importance of pre-integration region peaks are dealt with.
Hemoglobinopathies in the Çukurova Region and Neighboring Provinces.Yuzbasioglu Ariyurek S1, Yildiz SM1, Yalin AE2, Guzelgul F3, Aksoy K3. Hemoglobin. 2016 Mar 17:1-5. [Epub ahead of print]
Abstract:To contribute to the creation of a mutation map of the region, we aimed to determine the mutation spectrum of thalassemias and abnormal hemoglobins (Hbs) in the Çukurova region and surrounding provinces. In this study, a total of 8135 samples from Adana, Hatay, Mersin, Konya and Kayseri provinces between 1993 and 2014 were analyzed. Complete blood cell (CBC) counts and Hb typing were carried out using automatic cell counters, cellulose acetate membrane electrophoresis and high performance liquid chromatography (HPLC), respectively. For the molecular analyses, genomic DNA was extracted using both manual and automated DNA extraction devices. Determination of Hb mutations were done by microarray, restriction fragment length polymorphism (RFLP), amplification refractory mutation system (ARMS) and gap-polymerase chain reaction (gap-PCR) methodologies. Samples were analyzed for abnormal Hb and thalassemia mutations. Out of 8135 samples, 1382 were observed to be carrying Hb mutations.
Inaccurate pulse CO-oximetry of carboxyhemoglobin due to digital clubbing: case report.Harlan N, Weaver LK, Deru K. Undersea Hyperb Med. 2016 Jan-Feb;43(1):59-61.
Abstract:Newer pulse CO-oximeters provide a non-invasive and quick means of measuring oxyhemoglobin, carboxyhemoglobin and methemoglobin. Clubbing has been reported to cause inaccuracy in pulse oximeters. We present a case of inaccurate carboxy-hemoglobin measurement by pulse CO-oximetry due to digital clubbing. An 18-year-old man with a history of cystic fibrosis presented after a suicide attempt by inhalation of exhaust. At the initial emergency department evaluation, his blood carboxyhemoglobin was 33%. He was intubated, placed on 100% oxygen and transferred to our facility. Upon arrival, we placed three different pulse CO-oximeters on different fingers and toes. Carboxyhemoglobin levels measured by these meters ranged from 9%-11%. A venous blood gas drawn on arrival showed a carboxyhemoglobin level of 2.3% after four hours on 100% oxygen by endotracheal tube. Thirty minutes later, we checked arterial blood gas, which revealed a COHb level of 0.
Abstract:Neonatal cyanosis is relatively common. It is usually a consequence of cyanotic heart disease or a pulmonary disorder, and warrants a thorough and quick investigation. Mutations causing decreased affinity of hemoglobin to oxygen may change α1 to β2 binding. We describe a new mutation (asp 102 serine), in the γ chain of hemoglobin, causing neonatal cyanosis which resolves as the baby matures. In this case we would like to emphasize the importance of early diagnosis in order to avoid unnecessary disease workup.
Cation-exchange high-performance liquid chromatography for variant hemoglobins and HbF/A2: What must hematopathologists know about methodology?Sharma P1, Das R1. World J Methodol. 2016 Mar 26;6(1):20-4. doi: 10.5662/wjm.v6.i1.20. eCollection 2016.
Abstract:Cation-exchange high-performance liquid chromatography (CE-HPLC) is a widely used laboratory test to detect variant hemoglobins as well as quantify hemoglobins F and A2 for the diagnosis of thalassemia syndromes. It's versatility, speed, reproducibility and convenience have made CE-HPLC the method of choice to initially screen for hemoglobin disorders. Despite its popularity, several methodological aspects of the technology remain obscure to pathologists and this may have consequences in specific situations. This paper discusses the basic principles of the technique, the initial quality control steps and the interpretation of various controls and variables that are available on the instrument output. Subsequent sections are devoted to methodological considerations that arise during reporting of cases. For instance, common problems of misidentified peaks, totals crossing 100%, causes of total area being above or below acceptable limits and the importance of pre-integration region peaks are dealt with.
Hemoglobinopathies in the Çukurova Region and Neighboring Provinces.Yuzbasioglu Ariyurek S1, Yildiz SM1, Yalin AE2, Guzelgul F3, Aksoy K3. Hemoglobin. 2016 Mar 17:1-5. [Epub ahead of print]
Abstract:To contribute to the creation of a mutation map of the region, we aimed to determine the mutation spectrum of thalassemias and abnormal hemoglobins (Hbs) in the Çukurova region and surrounding provinces. In this study, a total of 8135 samples from Adana, Hatay, Mersin, Konya and Kayseri provinces between 1993 and 2014 were analyzed. Complete blood cell (CBC) counts and Hb typing were carried out using automatic cell counters, cellulose acetate membrane electrophoresis and high performance liquid chromatography (HPLC), respectively. For the molecular analyses, genomic DNA was extracted using both manual and automated DNA extraction devices. Determination of Hb mutations were done by microarray, restriction fragment length polymorphism (RFLP), amplification refractory mutation system (ARMS) and gap-polymerase chain reaction (gap-PCR) methodologies. Samples were analyzed for abnormal Hb and thalassemia mutations. Out of 8135 samples, 1382 were observed to be carrying Hb mutations.
Inaccurate pulse CO-oximetry of carboxyhemoglobin due to digital clubbing: case report.Harlan N, Weaver LK, Deru K. Undersea Hyperb Med. 2016 Jan-Feb;43(1):59-61.
Abstract:Newer pulse CO-oximeters provide a non-invasive and quick means of measuring oxyhemoglobin, carboxyhemoglobin and methemoglobin. Clubbing has been reported to cause inaccuracy in pulse oximeters. We present a case of inaccurate carboxy-hemoglobin measurement by pulse CO-oximetry due to digital clubbing. An 18-year-old man with a history of cystic fibrosis presented after a suicide attempt by inhalation of exhaust. At the initial emergency department evaluation, his blood carboxyhemoglobin was 33%. He was intubated, placed on 100% oxygen and transferred to our facility. Upon arrival, we placed three different pulse CO-oximeters on different fingers and toes. Carboxyhemoglobin levels measured by these meters ranged from 9%-11%. A venous blood gas drawn on arrival showed a carboxyhemoglobin level of 2.3% after four hours on 100% oxygen by endotracheal tube. Thirty minutes later, we checked arterial blood gas, which revealed a COHb level of 0.
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