草苔虫素 1|Bryostatin 1|83314-01-6|MFCD00893832-范德生物科技公司

草苔虫素 1

草苔虫素 1
NMR and HPLC COA下载 MSDS下载
Names：
Bryostatin 1
CAS号：
83314-01-6
MDL Number： MFCD00893832
MF(分子式)： C47H68O17 MW(分子量)： C47H68O17
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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DBK502017-100mg	100mg		¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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中文别名	草苔虫素 -1；草苔虫素杂质；草苔虫素 A;
英文别名	Bryostatin 1； UNII-37O2X55Y9E； 83314-01-6； NSC 339555； CHEMBL449158； Bryostatin-1； CHEBI:88353； 7O2X55Y9E； BRYOSTATIN； BRN 4349157；[(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-acetyloxy-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl] (2E,4E)-octa-2,4-dienoate;EH9455000
CAS号	83314-01-6
SMILES	CCCC=CC=CC(=O)OC1C(=CC(=O)OC)CC2CC(OC(=O)CC(CC3CC(C(C(O3)(CC4CC(=CC(=O)OC)CC(O4)C=CC(C1(O2)O)(C)C)O)
Inchi	InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1
InchiKey	MJQUEDHRCUIRLF-TVIXENOKSA-N
分子式 Molecular Weight	C47H68O17
分子量 Formula	C47H68O17
闪点 FP	270.0±27.8 °C
熔点 Melting point	Not avilable
沸点 Boiling point	954.7±65.0 °C at 760 mmHg
Polarizability极化度	91.6±0.5 10-24cm3
密度 Density	1.3±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±0.6 mmHg at 25°C
溶解度Solubility	叔丁醇t-Butanol > 9.2 (mg/mL)；50% Butanol/water > 3.0 (mg/mL)；PET solvent* > 2.8 (mg/mL)；PEG 400 (60mL)/EtOH (30mL)/Tween 80 (10 mL) (mg/mL)
性状	white;solid; power
储藏条件 Storage conditions	Store at -4℃； -20℃存储更长时间（2-3年）

产品说明	Bryostatin 1是从具有抗肿瘤活性的苔藓虫（Bugula neritina）分离的大环内酯。 Bryostatin 1结合并抑制细胞信号转导酶蛋白激酶C，从而抑制肿瘤细胞增殖，促进肿瘤细胞分化和诱导肿瘤细胞凋亡，该试剂可以与其他化学治疗剂协同作用。
Introduction	Some phorbol esters might partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cells
Application1	Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects
Application2	Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon
Application3	The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line

Bryostatin 1是从具有抗肿瘤活性的苔藓虫（Bugula neritina）分离的大环内酯。 Bryostatin 1结合并抑制细胞信号转导酶蛋白激酶C，从而抑制肿瘤细胞增殖，促进肿瘤细胞分化和诱导肿瘤细胞凋亡。该试剂可以与其他化学治疗剂协同作用。

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.

警示图
危险性
危险性警示	Mouse(iv): LD50: 0.075 mg/kg;Rat(iv): LD50: 0.068 mg/kg
安全声明	H303+H313+H333
安全防护	P264+P280+P305+P351+P338+P337+P313
备注